In this work, starting from an approach previously proposed by the Authors, we put forward an extension to the large deformation regime of the dimensionally-reduced formulation for peridynamic thin plates, including both hyperelasticity and fracture. In particular, the model, validated against numerical simulations, addresses the problem of the peeling in nonlocal thin films, which when attached to a soft substrate highlights how nonlocality of the peeled-off layer might greatly influence the whole structural response and induce some unforeseen mechanical behaviours that could be useful for engineering applications. Through a key benchmark example, we in fact demonstrate that de-localization of damage and less destructive failure modes take place, these effects suggesting the possibility of ad hoc conceiving specific networks of nonlocal interactions between material particles, corresponding to lattice-equivalent structure of the nonlocal model treated, of interest in designing new material systems and interfaces with enhanced toughness and adhesive properties.

The need, or even the obligation, to take care of the natural environment compels a search for new technological solutions, or for known solutions to be adapted to new applications. The maxim is \'don\'t harm, but improve the world for future generations\'. In the wood industry in particular, given that it is based on a natural raw material, we must look for ecological solutions. Trees grow, but the demand for wood exceeds the volume of tree growth. In industrial manufacturing, one of the ways to make full use of wood is through chipless processing, which occurs during rotary cutting (peeling). In addition, wood is a natural material, each fragment of which has a range of properties. In addition, wood defects in quality manipulation generate a lot of waste. The aim of this study was to analyse the quality effect of the tested layered composites for flooring materials on production application. The practical purpose was to exchange actual sawing-based production for chipless production. The composite base layers were made of pine wood (Pinus L.) veneers with differing quality classes. The samples were subjected to three-point bending tests to calculate the moduli of elasticity and stiffness, which are the most important parameters. Because both analysed parameters describe product quality, the analyses were based on the creation of Shewhart control charts for each parameter. In theory, these control charts are tools for analysing whether the production process is stable and yields predictable results. To have full control over the process, five elements have to be applied: central line (target), two types of control lines (upper and lower) and two types of specification lines (upper and lower). New types of layered composites for flooring may be applied to production once verified using Shewhart control charts. It turns out that it is possible to produce the base layer of the flooring materials using the rotary cutting (peeling) method without having to analyse the quality of the raw material. This is a way to significantly increase the efficiency of production in every element of manufacturing.

BACKGROUND: Acanthosis nigricans is a non-inflammatory skin pigmentary disorder characterized by a dark, velvety appearance, primarily observed in the neck and axillary areas. It is commonly associated with obesity, diabetes, and insulin resistance. Although the primary treatment is correcting the underlying disorders, many aesthetic modalities have been established to improve appearance owing to cosmetic concerns.
OBJECTIVE: We aimed to compare and investigate the effectiveness and side effects of tretinoin 0.05% and glycolic acid 70% in treating acanthosis nigricans lesions of the axillary and neck area.
METHODS: This single-blinded, randomized trial recruited patients with neck or axillary involvement. Each patient was randomized to use cream tretinoin 0.05% every other night on one side, while the other side was treated with glycolic acid 70%, which was applied every 2 weeks at the clinic for four consecutive sessions. The study duration was 8 weeks, and patients were evaluated every 2 weeks based on their response to treatment, satisfaction, and side effects.
RESULTS: Thirty patients, including 14 with neck lesions and 16 with axillary lesions, were included. Tretinoin was significantly more effective for axillary lesions in terms of treatment response and patient satisfaction (p = 0.02 and p = 0.008, respectively). It was also shown that as the severity of the lesions increased, the response to treatment and patient satisfaction decreased, specifically when treating axillary lesions with glycolic acid (p = 0.02 and p = 0.03, respectively).
CONCLUSIONS: Neither method was significantly effective for neck lesions. However, tretinoin 0.05% was shown to be more efficacious in treating axillary lesions of acanthosis nigricans, despite causing minimal side effects.

Mucin glycomic analysis is crucial owing to the participation of mucin O-glycans in several biological functions. Liquid chromatographic analysis of fluorescently labeled glycans is an effective tool for glycomic analysis. The first step of this analysis involves the release of O-glycans from mucins. As no enzyme is known to release all glycans, chemical methods are required for the process; therefore, hydrazine treatment is a commonly used chemical method. It enables the release of O-glycans from mucin while preserving the aldehyde group at the reducing end. This ensures that the reducing end can be modified using fluorescent reagents. However, it is also accompanied by the degradation of the glycans through a process called \"peeling.\" Here, we describe a method for releasing glycans from mucins using hydrazine treatment with minimal \"peeling.\"

This paper is the fourth in a series dedicated to the mathematically rigorous asymptotic analysis of gravitational radiation under astrophysically realistic set-ups. It provides an overview of the physical ideas involved in setting up the mathematical problem, the mathematical challenges that need to be overcome once the problem is posed, as well as the main new results we will obtain in upcoming work. From the physical perspective, this includes a discussion of how post-Newtonian theory provides a prediction on the gravitational radiation emitted by [Formula: see text] infalling masses from the infinite past in the intermediate zone, i.e. up to some finite advanced time. From the mathematical perspective, we then take this prediction, together with the condition that there be no incoming radiation from [Formula: see text], as a starting point to set up a scattering problem for the linearized Einstein vacuum equations around Schwarzschild and near spacelike infinity, and we outline how to solve this scattering problem and obtain the asymptotic properties of the scattering solution near [Formula: see text] and [Formula: see text]. The full mathematical details will be presented in the sequel to this paper. This article is part of a discussion meeting issue \'At the interface of asymptotics, conformal methods and analysis in general relativity\'.

The asymptotic behaviour of massless spin-0 fields close to spatial and null infinity in Minkowski space-time is studied by means of Friedrich\'s cylinder at spatial infinity. The results are applied to a system of equations called the good-bad-ugly which serves as a model for the Einstein field equations in generalized harmonic gauge. The relation between the logarithmic terms (polyhomogeneity) appearing in the solution obtained using conformal methods and those obtained by means of a heuristic method based on Hörmander\'s asymptotic system is discussed. This review article is based on Duarte et al. (Duarte et al. 2023 Class. Quantum Gravity 40, 055002. (doi:10.1088/1361-6382/acb47e)); Gasperín & Pinto (Gasperín & Pinto 2023 Spin-0 fields and the NP-constants close to spatial infinity in Minkowski spacetime. J. Math. Phys. 64, 082502. (doi:10.1063/5.0158746)). This article is part of a discussion meeting issue \'At the interface of asymptotics, conformal methods and analysis in general relativity\'.

In order to better manage the peeling degree and avoid unnecessary losses, the current work aimed to explore the peeling mechanism of a novel peeling technology, high-humidity hot air impingement blanching (HHAIB). The relationships between HHAIB peeling performance and the changes in skin temperature, skin structure, water state, pectin fractions content, and skin mechanical properties of tomatoes were analyzed. Results showed, after HHAIB treatment, the epicuticular wax was disrupted, the skin exhibited more and longer random cracks, the degradation of inner skin tissue was observed by transmission electron microscopy, the free water percentage increased resulting in water loss in the whole tomato, the water-soluble pectin contents decreased in tomato fleshes, while the contents of chelate-soluble pectin and sodium-carbonate-soluble pectin increased. HHAIB heating reduced the elongation at break, and increased Young\'s Modulus of tomato peel. This study revealed the HHAIB peeling mechanism and provided new insights for developing HHAIB peeling technology.

Lower eyelid skin is unique and different from that of other areas. In addition to being an area of high exposure to the sun and elements, there are anatomic considerations and specific histologic characteristics that can cause the skin in this area to be more sensitive. These attributes can readily cause under-eye wrinkling and pigmentation. This review aims to present an updated overview of the current knowledge regarding the clinical characteristics, diagnosis, and management of wrinkles and pigmentation in this area. These disorders are usually caused by different factors, such as genetics, aging, sun exposure, lack of sleep, and stress.

Chemical peeling is a procedure used for cosmetic improvement of the skin or treatment of some medical skin disorders, by the application of chemical exfoliant. In spite of a long history of clinical use of chemical peels, understanding of the science behind the procedure is still evolving. In this article, we review new concepts, understandings, and publications in the field of chemical peels.

OBJECTIVE: To evaluate the clinical efficacy of peeling with a microemulsion formulation containing 1% retinoic acid.
METHODS: After development of the product, 60 patients with melasma were randomly divided into three groups (n = 20): Group 1-application of conventional 1% retinoic acid peeling (RA 1%). Group 2-application of 1% retinoic acid peeling in microemulsion (RA 1%M). Group 3-Application of placebo. The groups were submitted to four peeling sessions, fortnightly on Days 0, 15, 30, and 45, and analyzed at the time intervals of 0, 15, 30, 45, and 60 days. Evaluation was made by using the Melasma Area and Severity Index (MASI) and Melasma Quality of Life (MelasquoL) instrument. Hemato-biochemical parameters were also evaluated at Days 0 and 60. After obtaining the results, normality was evaluated by means of the Kolmogorov-Smirnov test and afterwards, the following tests were applied: Friedman statistical (to test the effect of the treatments on the MASI index); Wilcoxon, (for comparison between pairs to test the effect of treatments on the MelasQoL index); Kruskal-Wallis, (to test the differences between the groups); and Mann-Whitney, (comparisons between treatments). The level of significance adopted was 5% (α = 0.05).
RESULTS: The three groups presented a significant reduction in the MASI index, indicating the effect of all the treatments on reducing the melasma (p < 0.001). A significant reduction in the stains was observed with the use of retinoic acid peeling delivered in microemulsion (62%) when compared with the conventional peeling with 1% retinoic acid in a conventional vehicle (26%) and the placebo (12%). There was also a significant reduction in the MelasQoL index (sum of all the aspects) in the three groups, indicating the effect of all the treatments, including the placebo, on the overall quality of life of those with melasma. However, RA 1%M the treatment that promoted the greatest effect on the quality of life of individuals. In percentage terms, the RA 1%M provided a mean reduction of 30% in the MelasQoL index, against 13% of the conventional treatment and only 4% of the placebo. When the hemato-biochemical parameters were compared on Days 0 and 60, there were no significant changes in the results.
CONCLUSIONS: The chemical peeling performed with RA 1%M was effective for the treatment of melasma, and was shown to be superior to the peeling performed with retinoic acid in a conventional vehicle, in reducing the stains and improving the quality of life of patients.