This paper is the fourth in a series dedicated to the mathematically rigorous asymptotic analysis of gravitational radiation under astrophysically realistic set-ups. It provides an overview of the physical ideas involved in setting up the mathematical problem, the mathematical challenges that need to be overcome once the problem is posed, as well as the main new results we will obtain in upcoming work. From the physical perspective, this includes a discussion of how post-Newtonian theory provides a prediction on the gravitational radiation emitted by [Formula: see text] infalling masses from the infinite past in the intermediate zone, i.e. up to some finite advanced time. From the mathematical perspective, we then take this prediction, together with the condition that there be no incoming radiation from [Formula: see text], as a starting point to set up a scattering problem for the linearized Einstein vacuum equations around Schwarzschild and near spacelike infinity, and we outline how to solve this scattering problem and obtain the asymptotic properties of the scattering solution near [Formula: see text] and [Formula: see text]. The full mathematical details will be presented in the sequel to this paper. This article is part of a discussion meeting issue \'At the interface of asymptotics, conformal methods and analysis in general relativity\'.

BACKGROUND: To report a clinical case of a patient affected with choroideremia (CHM) who underwent macular surgery for a macular hole (MH) with Lamellar Hole-associated Epiretinal Proliferation (LHEP).
METHODS: We have described a 48-year-old male patient affected with CHM who developed MH with LHEP over a 7-year follow-up. The patient was referred to the Regional Center for Hereditary Retinal Degenerations of the Eye Clinic in Florence (Italy) in April 2012. The patient underwent vitrectomy and Inner Limiting Membrane (ILM) and LHEP peeling with fluid-air exchange. Ultra-structural examination of the excised epiretinal proliferation, carried out using electron microscopy, showed dense amorphous material, mainly composed of abundant clusters of fibrous collagens resembling compact fibrous long spacing collagen (FLSC), embedded in native vitreous collagen (NVC) and type IV collagen. No cells were detected in any of the specimens collected. At the 3rd-week postoperative follow-up the macular hole was closed.
CONCLUSIONS: Macular hole with LHEP can be detected in CHM patients; in our patient the macular hole showed tractional and degenerative features, with good anatomical results after macular surgery.

Peeling of layered materials from supporting substrates, which is central for exfoliation and transfer processes, is found to be dominated by lattice commensurability effects in both low and high velocity limits. For a graphene nanoribbon atop a hexagonal boron nitride surface, the microscopic peeling behavior ranges from stick-slip, through smooth-sliding, to pure peeling regimes, depending on the relative orientation of the contacting surfaces and the peeling angle. The underlying mechanisms stem from the intimate relation between interfacial registry, interlayer interactions, and friction. This, in turn, allows for devising simple models for extracting the interfacial adhesion energy from the peeling force traces.

A histological evaluation of peeling-induced skin changes in subcutaneous undermined preauricular facial skin flaps of nine patients was performed. There were three treatment groups: Trichloroacetic acid (TCA) 25%, TCA 40% and phenol/croton oil; one group served as control. Two independent evaluators determined the epidermal and dermal thickness and the depth of necrosis (micrometre). The percentual tissue damage due to the peeling was calculated, and a one-sample t-test for statistical significance was performed. On the basis of the histomorphological changes, peeling depth was classified as superficial, superficial-partial, deep-partial and full thickness chemical burn. The histological results revealed a progression of wound depth for different peeling agents without full thickness necrosis. TCA peels of up to 40% can be safely applied on subcutaneous undermined facial skin flaps without impairing the vascular patency, producing a predictable chemical burn, whereas deep peels such as phenol/croton oil peels should not be applied on subcutaneous undermined skin so as to not produce skin slough or necrosis by impairing vascular patency.