Abstract：
BACKGROUND: Acanthosis nigricans is a non-inflammatory skin pigmentary disorder characterized by a dark, velvety appearance, primarily observed in the neck and axillary areas. It is commonly associated with obesity, diabetes, and insulin resistance. Although the primary treatment is correcting the underlying disorders, many aesthetic modalities have been established to improve appearance owing to cosmetic concerns.
OBJECTIVE: We aimed to compare and investigate the effectiveness and side effects of tretinoin 0.05% and glycolic acid 70% in treating acanthosis nigricans lesions of the axillary and neck area.
METHODS: This single-blinded, randomized trial recruited patients with neck or axillary involvement. Each patient was randomized to use cream tretinoin 0.05% every other night on one side, while the other side was treated with glycolic acid 70%, which was applied every 2 weeks at the clinic for four consecutive sessions. The study duration was 8 weeks, and patients were evaluated every 2 weeks based on their response to treatment, satisfaction, and side effects.
RESULTS: Thirty patients, including 14 with neck lesions and 16 with axillary lesions, were included. Tretinoin was significantly more effective for axillary lesions in terms of treatment response and patient satisfaction (p = 0.02 and p = 0.008, respectively). It was also shown that as the severity of the lesions increased, the response to treatment and patient satisfaction decreased, specifically when treating axillary lesions with glycolic acid (p = 0.02 and p = 0.03, respectively).
CONCLUSIONS: Neither method was significantly effective for neck lesions. However, tretinoin 0.05% was shown to be more efficacious in treating axillary lesions of acanthosis nigricans, despite causing minimal side effects.
OBJECTIVE: We aimed to compare and investigate the effectiveness and side effects of tretinoin 0.05% and glycolic acid 70% in treating acanthosis nigricans lesions of the axillary and neck area.
METHODS: This single-blinded, randomized trial recruited patients with neck or axillary involvement. Each patient was randomized to use cream tretinoin 0.05% every other night on one side, while the other side was treated with glycolic acid 70%, which was applied every 2 weeks at the clinic for four consecutive sessions. The study duration was 8 weeks, and patients were evaluated every 2 weeks based on their response to treatment, satisfaction, and side effects.
RESULTS: Thirty patients, including 14 with neck lesions and 16 with axillary lesions, were included. Tretinoin was significantly more effective for axillary lesions in terms of treatment response and patient satisfaction (p = 0.02 and p = 0.008, respectively). It was also shown that as the severity of the lesions increased, the response to treatment and patient satisfaction decreased, specifically when treating axillary lesions with glycolic acid (p = 0.02 and p = 0.03, respectively).
CONCLUSIONS: Neither method was significantly effective for neck lesions. However, tretinoin 0.05% was shown to be more efficacious in treating axillary lesions of acanthosis nigricans, despite causing minimal side effects.
摘要：
背景：黑棘皮病是一种非炎症性皮肤色素性疾病，其特征是深色，天鹅绒般的外观，主要在颈部和腋窝区域观察到。它通常与肥胖有关，糖尿病,和胰岛素抵抗。尽管主要治疗是纠正潜在的疾病，由于美容方面的考虑，已经建立了许多美学方式来改善外观。
目的：我们旨在比较和研究维甲酸0.05％和乙醇酸70％治疗腋窝和颈部黑棘皮病的有效性和副作用。
方法：这种单盲，随机试验招募了颈部或腋窝受累患者.每位患者随机在一侧每隔一晚使用0.05％的乳膏维甲酸，而另一侧用70%的乙醇酸处理，每2周在诊所应用一次，连续四次。研究时间为8周，每两周根据患者对治疗的反应进行评估，满意,和副作用。
结果：30名患者，其中颈部病变14例,腋窝病变16例,包括在内。维甲酸在治疗反应和患者满意度方面显着更有效（分别为p=0.02和p=0.008）。研究还表明，随着病变严重程度的增加，对治疗的反应和患者满意度下降，特别是在用乙醇酸治疗腋窝病变时（分别为p=0.02和p=0.03）。
结论：两种方法对颈部病变均无明显疗效。然而,0.05％的维甲酸被证明在治疗黑棘皮病的腋窝病变方面更有效，尽管副作用很小。
目的：我们旨在比较和研究维甲酸0.05％和乙醇酸70％治疗腋窝和颈部黑棘皮病的有效性和副作用。
方法：这种单盲，随机试验招募了颈部或腋窝受累患者.每位患者随机在一侧每隔一晚使用0.05％的乳膏维甲酸，而另一侧用70%的乙醇酸处理，每2周在诊所应用一次，连续四次。研究时间为8周，每两周根据患者对治疗的反应进行评估，满意,和副作用。
结果：30名患者，其中颈部病变14例,腋窝病变16例,包括在内。维甲酸在治疗反应和患者满意度方面显着更有效（分别为p=0.02和p=0.008）。研究还表明，随着病变严重程度的增加，对治疗的反应和患者满意度下降，特别是在用乙醇酸治疗腋窝病变时（分别为p=0.02和p=0.03）。
结论：两种方法对颈部病变均无明显疗效。然而,0.05％的维甲酸被证明在治疗黑棘皮病的腋窝病变方面更有效，尽管副作用很小。
