全球皮肤癣菌感染占真菌感染的20%至25%。皮肤癣菌已经开始表现出抗真菌耐药性,使得治疗这种特殊感染具有挑战性。精油可以用作替代解决方案,因为它们已经长期用于治疗不同的感染。这项研究证明了肉桂的抗真菌功效,丁香,柠檬草,茶树,百里香,和大蒜精油,并分析了它们的组合对犬小孢子菌的影响,扁桃体毛癣菌,T.紫罗兰,T.疣,和絮状表皮组织。使用聚合酶链反应(PCR)-限制性片段长度多态性(RFLP)来鉴定最普遍的犬分枝杆菌。获得M.canis的登录号为ON007275。除大蒜外,所有测试的精油均表现出抗皮肤癣菌作用。肉桂+丁香达到了协同效应,肉桂+柠檬草,丁香+柠檬草,丁香+茶树,和百里香+茶树组合。关于抗真菌活性,犬分枝杆菌是最易感的皮肤癣菌,除了百里香T.violaceum,这是最易感的皮肤科物种。在肉桂和肉桂+柠檬草组合对犬分枝杆菌的最大抑制作用。肉桂和丁香对M.canis的抑制浓度最低,肉桂+丁香对抗犬M.canis和T.violaceum,和肉桂+柠檬草对抗犬M.canis,T.紫罗兰,T.疣,和E.絮凝剂。肉桂对M.canis显示的最低杀菌浓度,肉桂+丁香对抗犬M.canis和T.violaceum,肉桂+柠檬草对抗M.canis,T.紫罗兰,T.疣,和E.絮凝剂,丁香+柠檬草对抗犬。
Dermatophyte infections globally account for 20 to 25% of fungal infections. Dermatophytes have begun exhibiting antifungal drug resistance, making it challenging to treat this particular infection. Essential oils could be used as alternative solutions as they have been used for a long period to treat different infections. The research has demonstrated the antifungal efficacy of cinnamon, clove, lemongrass, tea tree, thyme, and garlic essential oils, and the impact of their combinations was assayed against Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum, and Epidermophyton floccosum. Polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) was used to identify the most prevalent M. canis. The accession number of M. canis was obtained as ON007275. All tested essential oils exhibited antidermatophytic action except garlic. A synergistic effect was attained by cinnamon + clove, cinnamon + lemongrass, clove + lemongrass, clove + tea tree, and thyme + tea tree combinations. Concerning antifungal activity, M. canis was the most susceptible dermatophytic species, except in the case of thyme T. violaceum, which was the most susceptible dermatophytic species. The maximum inhibition was recorded in the cases of cinnamon and cinnamon + lemongrass combination against M. canis. The least minimum inhibitory concentrations were attained by cinnamon and clove against M. canis, cinnamon + clove against M. canis and T. violaceum, and cinnamon + lemongrass against M. canis, T. violaceum, T. verrucosum, and E. floccosum. The least minimum fungicidal concentration showed by cinnamon against M. canis, cinnamon + clove against M. canis and T. violaceum, cinnamon + lemongrass against M. canis, T. violaceum, T. verrucosum, and E. floccosum, and clove + lemongrass against M. canis.