耐药病原微生物的加速出现,在过去的十年中,它们无与伦比的毒力和目前使用的抗菌剂的功效逐渐丧失,扩大了草药的范围,以应对这一新兴挑战,以具有广泛的活性来开发具有较小副作用的有效药物。基于植物的天然产品应该是当今制药行业最感兴趣的,因为它们是针对新药靶标的新化学实体的主要来源。作为一些拯救生命的植物衍生产品和新型化合物的来源,夹竹桃科或“Dogbane”家族已获得全球声誉。通过体外和体内实验设置,还对该家族的成员进行了针对几种医院病原微生物的广泛研究。从该家族成员获得的几种植物来源的成分也表现出显著的微生物生长抑制特性。流行和广泛接受的国际数据库,如PubMed,科学直接,ResearchGate,Scopus,谷歌学者,JSTOR和更多的搜索使用各种搜索字符串,如夹竹桃科,抗菌药物,多药耐药,抗性修饰剂和病原微生物以各种组合使用,以检索与该主题相关的一些引文。当前的综述涵盖了实验研究和植物化学分析的最新发展,这些研究与选定的紫罗兰植物的抗微生物功效以及协同机理和结构细节相关。本综述认识到并利用了夹竹桃科植物的重要性,这对开发更有效,毒性更小的抗菌药物可能具有重要意义,可以克服多药耐药性。利用临床抗菌素耐药性(AMR)的三种不同范式模型,包括植物科,在这篇综述中广泛讨论了革兰氏阳性和革兰氏阴性细菌物种。简而言之,本综述全面介绍了从植物科植物科和衍生的植物化学物质中获得的抗菌剂和抗性调节剂。它还可以深入了解这些植物化学物质对一系列致病菌的潜在作用方式,它们的抗菌机制,分离植物化学物质或制备提取物的植物部分,并对植物学来源的抗生素作为抗微生物药物开发的模板进行了严格的讨论。
Accelerated emergence of drug- resistant pathogenic microbes, their unbeatable virulence and a gradual loss of efficacy of currently used antimicrobial agents over the last decade, have expanded the scope of herbal medicine to combat this emerging challenge to have a wide spectrum of activity to develop effective medicines with lesser untoward side effects. Plant-based natural products should be of utmost interest to today\'s pharmaceutical industries since they are a primary source of new chemical entities directed at new drug targets. Apocynaceae or \'Dogbane\' family has attained a global reputation as a source of some life-saving plant-derived products and novel compounds. Members of this family have also been extensively investigated against several nosocomial pathogenic microbes through in vitro and in vivo experimental settings. Several plant-derived components obtained from members of this family have also exhibited remarkable microbial growth inhibitory properties. Popular and widely accepted international databases such as PubMed, Science Direct, ResearchGate, Scopus, Google Scholar, JSTOR and more were searched using the various search strings such as Apocynaceae, antimicrobials, multidrug resistance, resistance modifying agents and pathogenic microorganisms were used in various combinations to retrieve several citations related to the topic. The current
review encompasses recent developments in experimental studies and phytochemical analyses which correlates with antimicrobial efficacy of selected Apocynaceous plants along with synergistic mechanism and structural details. The present
review recognizes and leverages the importance of Apocynaceae plants, which could be of significant interest in the development of more effective and less toxic antimicrobial drugs which may surmount multidrug resistance. Three different paradigm models harnessing clinical antimicrobial resistance (AMR) including the plant family Apocynaceae, Gram-positive and Gram-negative bacterial species have been broadly discussed in this
review. In a nutshell, the present
review represents a comprehensive account on the antimicrobials and resistance modifying agents obtained from the members of the plant family Apocynaceae and derived phytochemicals. It also gives an insight into the underlying mode of action of these phytochemicals against an array of pathogenic bacteria, their mechanism of antibiosis, plant parts from which the phytochemicals were isolated or the extracts was prepared with a critical discussion on the botanically-derived antibiotics as a template for antimicrobial drug development.