目标:肥胖,以异常脂肪积累和代谢紊乱为特征,提出了重大的健康挑战。仙人掌。,俗称韩国天龙云,富含各种有益化合物,并具有抗氧化和抗炎作用。然而,它对葡萄糖和脂质代谢的潜在影响,特别是肥胖的老鼠,仍未探索。我们的目的是研究在高脂饮食(HFD)诱导的肥胖的大鼠模型中,虎杖茎和果实是否可以有益地改变葡萄糖代谢和脂质分布。
方法:将32只大鼠分为4组:正常饮食(NF),HFD控制(HF),用2%O.humifusa茎(HF-OS)处理的HFD,和用2%0.hiffusa果实(HF-OF)处理的HFD。实验饮食给药6周。在治疗结束时,肝脏和脂肪组织被分离,收集血清进行生化分析。鉴定并定量了来自O.hiifusa茎和果实的主要类黄酮。
结果:治疗6周后,HF-OS组空腹血糖浓度明显低于HF组。HF-OS和HF-OF组的血清空腹胰岛素浓度均低于HF组,表明HF-OS组的胰岛素敏感性显着改善。此外,HF-OS组表现出脂联素水平恢复到NF组的趋势。
结论:2%的地黄茎含有丰富的槲皮素和异鼠李素,这改变了喂食HFD的大鼠的空腹血糖水平,导致胰岛素抵抗的良好改善。
OBJECTIVE: Obesity, characterized by abnormal fat accumulation and metabolic disturbances, presents a significant health challenge. Opuntia humifusa Raf., commonly known as Korean Cheonnyuncho, is rich in various beneficial compounds and has demonstrated antioxidant and anti-inflammatory effects. However, its potential impact on glucose and lipid metabolism, particularly in obese rats, remains unexplored. We aimed to investigate whether O. humifusa stems and fruits could beneficially alter glucose metabolism and lipid profiles in a rat model of high-fat diet (HFD)-induced obesity.
METHODS: Thirty-two rats were allocated into 4 groups: normal diet (NF), HFD control (HF), HFD treated with 2% O. humifusa stems (HF-OS), and HFD treated with 2% O. humifusa fruits (HF-OF). Experimental diets were administered for 6 weeks. At the end of the treatment, liver and fat tissues were isolated, and serum was collected for biochemical analysis. The major flavonoid from O. humifusa stems and fruits was identified and quantified.
RESULTS: After 6 weeks of treatment, the serum fasting glucose concentration in the HF-OS group was significantly lower than that in the HF group. Serum fasting insulin concentrations in both HF-OS and HF-OF groups tended to be lower than those in the HF group, indicating a significant improvement in insulin sensitivity in the HF-OS group. Additionally, the HF-OS group exhibited a tendency towards the restoration of adiponectin levels to that of the NF group.
CONCLUSIONS: The 2% O. humifusa stems contain abundant quercetin and isorhamnetin, which alter fasting blood glucose levels in rats fed a HFD, leading to a favorable improvement in insulin resistance.