■一些主要用于纺织工业的合成染料与内分泌干扰有关,导致不孕,在其他疾病中。尚不清楚绝经前染料中职业接触Vat纺织染料是否会改变激素水平。
■我们旨在确定职业性接触还原染料对卵泡期和黄体期女性纺织染料生殖激素的可能影响,同时将其与年龄类别和暴露持续时间相关。
■在\"Itoku\",Abeokuta,尼日利亚,在约80名女性参与者中,年龄和性别匹配者为55名非暴露(对照)女性参与者.使用半结构化问卷,社会人口统计学,获得参与者的职业细节和LMP.在卵泡期和黄体期收集血清样品,并使用酶免疫分析法测定雌性激素。采用Mann-WhitneyU和Z-统计量进行比较。P值<0.05被认为是显著的。
■在卵泡期,结果表明,暴露者的平均FSH排名较低(≤20岁),而雌二醇排名较高(p<0.05)(31-40岁)。黄体期(年龄31-40岁)的孕酮和雌二醇的平均等级在暴露者中较高(p<0.05),而雌二醇(年龄≥41岁)排名较低(p<0.05)。催乳素与暴露时间呈显着的负相关。
■在Abeokuta中,女性染料中的Vat染料的职业暴露与一些性激素破坏有关,这似乎与年龄和暴露时间有关。
UNASSIGNED: Some synthetic dyes used mainly in textile industries have been associated with endocrine disruption, resulting in infertility, among other disorders. It is unknown if occupational exposure to Vat textile dyes among premenopausal dyers alters hormonal levels.
UNASSIGNED: We aimed at determining the probable effects of occupational exposure to Vat dyes on reproductive hormones of female textile dyers in the follicular and luteal phases while relating this to age categories and duration of exposure.
UNASSIGNED: Thirty-three premenopausal Vat textile dyers at \"Itoku\", Abeokuta, Nigeria, among a population of about 80 female dyers were age and sex-matched with 55 non-exposed (control) female participants. Using semi-structured questionnaires, socio-demographic, occupational details and the LMP of participants were obtained. Serum samples were collected in follicular and luteal phases and assayed for female sex hormones using Enzyme Immunoassay. Mann-Whitney U and Z- statistic were used for comparison of the two groups. P-value < 0.05 was considered to be significant.
UNASSIGNED: In the follicular phase, the result showed a lower mean FSH ranking (in age category ≤20 years) and higher (p<0.05) Estradiol ranking (in age category 31-40 years) in the exposed than the unexposed. Mean ranks of Progesterone and Estradiol in the luteal phase (age category 31-40 years) were higher (p<0.05) in the exposed, while Estradiol (age category ≥41years) ranked lower (p<0.05). Prolactin demonstrated a significant inverse relationship with the duration of exposure.
UNASSIGNED: Occupational exposure to Vat dye among female dyers in Abeokuta is associated with some sex hormone disruption which appears to be age and duration of exposure-related.