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Abstract：
To evaluate the efficacy and safety of indocyanine green (ICG)-guided near-infrared fluorescence (NIRF) imaging during surgery to diagnose the cause of neonatal cholestasis (NC). Data on NC patients who underwent both NIRF with ICG and conventional laparoscopic bile duct exploration (the gold standard) at our institute from January 2022 to December 2022 were retrospectively analyzed. The patients\' baseline characteristics and liver function outcomes were collected and analyzed, and the diagnostic consistency was compared between the 2 methods. In total, 16 NC patients were included in the study, comprising 8 (50%) male and 8 (50%) female patients, ranging in age from 42 to 93 days, with a median age of 54.4 ± 21 days. During surgery, all the patients underwent NIRF with ICG, followed by conventional laparoscopic bile duct exploration. Finally, 15 of the patients were diagnosed with biliary atresia (BA) (1 with type-I BA, and 14 with type-II BA). The other patient was diagnosed with cholestasis. The diagnostic results from fluorescence imaging with ICG were consistent with those from conventional laparoscopic bile duct exploration. ICG-guided NIRF is associated with an easy operation, less trauma, and good safety. Also, its diagnostic accuracy is similar to conventional laparoscopic bile duct exploration.
摘要：
评价吲哚菁绿(ICG)引导的近红外荧光(NIRF)显像术中诊断新生儿胆汁淤积(NC)的有效性和安全性。回顾性分析2022年1月至2022年12月在我们研究所接受NIRF与ICG和常规腹腔镜胆管探查（金标准）的NC患者的数据。收集并分析患者的基线特征和肝功能结果，并比较2种方法的诊断一致性。总的来说,16名NC患者被纳入研究，包括8名（50%）男性和8名（50%）女性患者，年龄从42天到93天，年龄中位数为54.4±21天。手术期间,所有患者接受NIRF与ICG，随后进行常规腹腔镜胆管探查。最后,15例患者被诊断为胆道闭锁（BA）（1例患有I型BA，和14与II型BA）。另一名患者被诊断为胆汁淤积。ICG荧光成像的诊断结果与常规腹腔镜胆管探查的诊断结果一致。ICG引导的NIRF具有简单的操作，更少的创伤，和良好的安全性。此外，其诊断准确性与传统腹腔镜胆管探查术相似。
