背景:在本文中,我们使用健康与退休研究(HRS)来检查脉搏波速度(ePWV)的估计测量值与无痴呆和痴呆的认知障碍之间的关系,分别。
方法:我们在2006/2008年使用来自8,492名男性和女性(平均年龄68.6岁)控制年龄的数据,对ePWV与认知状态之间的关系进行了建模。血压,社会人口统计学和社会经济特征(性别,种族和民族,教育,收入,财富),健康行为(吸烟和身体活动),体重指数(BMI),健康状况和相关药物使用情况(心血管疾病史,糖尿病,和中风),和脑血管疾病(CVD)相关的生物标志物(C反应蛋白,胱抑素C,血红蛋白A1c,总胆固醇,高密度脂蛋白[HDL]胆固醇)。我们使用27项Langa-Weir认知状态电话访谈(TICS)量表评估认知功能。ePWV是从基于参与者年龄和静息血压的方程导出的。
结果:在控制ePWV组成成分的模型中(年龄,年龄的平方,收缩压和舒张压),与无认知障碍或痴呆的组相比,ePWV与无痴呆的认知障碍(OR=2.761)和痴呆(OR=6.344)的几率增加相关。在对ePWV的组成部件进行控制后,社会人口统计学和社会经济特征,健康状况和药物使用,健康行为,BMI,和CVD相关的生物标志物,ePWV仍然与痴呆显著相关(OR=3.969),但与无痴呆的认知障碍无关(OR=1.782)。
结论:这些发现表明,ePWV可能是一种新的血管老化研究工具和生物标志物,可用于大,研究认知老化和痴呆风险的人群代表性研究。
BACKGROUND: In this paper, we use the Health and Retirement Study (HRS) to examine the relationship between an estimated measure of pulse wave velocity (ePWV) and cognitive impairment with no dementia and dementia, respectively.
METHODS: We modeled the relationship between ePWV and cognitive status in 2006/2008 using data from 8,492 men and women (mean age 68.6 years) controlling for age, blood pressure, sociodemographic and socioeconomic characteristics (sex, race and ethnicity, education, income, wealth), health behaviors (smoking and physical activity), body mass index (BMI), health status and related medication use (history of cardiovascular disease, diabetes, and stroke), and cerebrovascular disease (CVD)-related biomarkers (C-reactive protein, cystatin-C, hemoglobin A1c, total cholesterol, high-density lipoprotein [HDL] cholesterol). We assess cognitive function with the 27-item Langa-Weir Telephone Interview for Cognitive Status (TICS) scale. ePWV is derived from an equation based on participant age and resting blood pressure.
RESULTS: In a model that controlled for the constituent components of ePWV (age, age squared, systolic and diastolic blood pressure), ePWV is associated with increased odds of having cognitive impairment with no dementia (OR=2.761) and dementia (OR=6.344) relative to a group with no cognitive impairment or dementia. After controlling for the constituent components of ePWV, sociodemographic and socioeconomic characteristics, health status and medication use, health behaviors, BMI, and CVD-related biomarkers, ePWV remains significantly associated with dementia (OR=3.969) but not cognitive impairment with no dementia (OR=1.782).
CONCLUSIONS: These findings suggest that ePWV may be a novel research tool and biomarker of vascular aging that can be used in large, population-representative studies to examine cognitive aging and dementia risk.