tracheoesophageal fistula

气管食管瘘
  • 文章类型: Journal Article
    气道干预,包括支架术,可以迅速改善病人的呼吸状况,但是该程序需要高度专业化的技术和专业知识。因此,教育年轻的内窥镜医师和传授技术是主要问题。然而,对新医生进行这些技术教育的最佳方法仍不清楚。本研究分析了我们的气道干预教育系统及其结果。
    在2010年1月至2023年9月期间在我们部门接受了关于全身麻醉下气道支架的气道干预的患者。回顾性评估我院与气道支架相关的干预措施的结果。包括从教育的角度。
    共96例患者(76例接受气道狭窄支架置入术,8气道食管瘘支架置入术,和12个支架移除)进行分析。主要医师的中位经验水平为5(范围,1-17)年,监督医生的年龄为18岁(范围,5-23)年。参与干预措施的医生人数中位数为4人。在86.5%的病例中使用了刚性支气管镜。手术成功率为95.8%。术中并发症发生率为8.3%,术后并发症发生率为10.5%,手术相关死亡1例(1.3%).在分析并发症发生的相关因素时,主要医师多年的经验没有影响.
    这些发现表明我们的气道干预方法是安全的。年轻的内窥镜医师能够通过在专家的监督下获得经验来掌握该技术。
    UNASSIGNED: Airway intervention, including stenting, can rapidly improve a patient\'s respiratory condition, but the procedure requires highly specialized techniques and expertise. Therefore, educating young endoscopists and passing on the techniques are major issues. However, the best way to educate new doctors on these techniques remains unclear. This study analyzed our educational system for airway intervention and its outcomes.
    UNASSIGNED: Patients who underwent airway intervention regarding airway stents under general anesthesia in our department between January 2010 and September 2023 were included. The outcomes of interventions related to airway stents in our hospital were evaluated retrospectively, including from an educational perspective.
    UNASSIGNED: A total of 96 patients (76 undergoing stenting for airway stenosis, 8 stenting for airway-esophageal fistula, and 12 stent removal) were analyzed. The median experience level of the main physician was 5 (range, 1-17) years, and that of the supervising physician was 18 (range, 5-23) years. The median number of physicians who participated in the interventions was four. A rigid bronchoscope was used in 86.5% of cases. The procedure success rate was 95.8%. Intraoperative complications occurred in 8.3% and postoperative complications in 10.5% of cases, and there was 1 procedure-related death (1.3%). In the analysis of factors related to the development of complications, the years of experience of the main physician had no influence.
    UNASSIGNED: These findings indicate that our method of airway intervention is safe. Young endoscopists were able to master the technique by gaining experience under the supervision of experts.
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  • 文章类型: Journal Article
    目的:胸腔镜下一期修补术治疗食管闭锁伴气管食管瘘的手术适应证有争议。本研究旨在调查体重<2000g的患者和在0日龄接受急诊手术的患者在胸腔镜下一期修复食管闭锁伴气管食管瘘的结果。
    方法:比较手术时体重<2000g和体重>2000g的患者以及0日龄手术和1日龄手术的患者的手术结果。
    结果:总计,43例食管闭锁伴气管食管瘘患者行胸腔镜一期修补术。根据体重的手术结果相似。在0日龄接受手术的患者比在≥1日龄接受手术的患者更容易发生吻合口漏(2与0例,p=0.02)。吻合口漏采用保守治疗。
    结论:胸腔镜一期修补术对于伴气管食管瘘的食管闭锁,即使在体重<2000g的新生儿中也是安全有效的。由于存在吻合口漏的风险,应谨慎进行0日龄的急诊手术。
    OBJECTIVE: The surgical indication of thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula is under debate. The current study aimed to investigate the outcome of thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula in patients weighing < 2000 g and those who underwent emergency surgery at the age of 0 day.
    METHODS: The surgical outcomes were compared between patients weighing < 2000 g and those weighing > 2000 g at surgery and between patients who underwent surgery at the age of 0 day and those who underwent surgery at age ≥ 1 day.
    RESULTS: In total, 43 patients underwent thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula. The surgical outcomes according to body weight were similar. Patients who underwent surgery at the age of 0 day were more likely to develop anastomotic leakage than those who underwent surgery at the age of ≥ 1 day (2 vs. 0 case, p = 0.02). Anastomotic leakage was treated with conservative therapy.
    CONCLUSIONS: Thoracoscopic primary repair is safe and useful for esophageal atresia with tracheoesophageal fistula even in newborns weighing < 2000 g. However, emergency surgery at the age of 0 day should be cautiously performed due to the risk of anastomotic leakage.
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  • 文章类型: Journal Article
    背景:气管食管瘘(TEF)尤其是恶性TEF(mTEF)是一种罕见但危重的医学疾病,需要立即干预。这种危及生命的状况通常表现在重症患者中,这些患者依赖于长时间的机械通气,并且由于健康状况受损而不适合进行开胸手术。这些mTEF患者的管理仍然是一个重大挑战。本研究旨在评估使用心脏间隔封堵器闭合mTEF的安全性和有效性。
    方法:于2021-2023年在湖北省宜昌市中心人民医院呼吸科行房间隔缺损(ASD/VSD)房间隔封堵器封堵术治疗8例mTEF患者。该过程涉及通过瘘管经皮放置封堵器以实现闭合。
    结果:在所有患者中,心脏间隔封堵器的放置均成功且有效。研究表明,使用心脏间隔封堵器治疗mTEF患者可以缓解症状,提高生活质量,提高生存率,无明显并发症。此外,这项研究提供了关于手术适应症的全面细节,术前评估和诊断,封堵器的选择,遮挡的方法,和术后护理。
    结论:应用心脏间隔封堵器治疗mTEF是一种安全有效的姑息性治疗方法。这种方法对于具有与传统手术干预相关的并发症和死亡率高风险的患者可能特别有益。
    BACKGROUND: Tracheoesophageal fistula (TEF) especially malignant TEF (mTEF) is an uncommon yet critical medical condition necessitating immediate intervention. This life-threatening condition frequently manifests in critically ill patients who are dependent on prolonged mechanical ventilation and are unsuitable candidates for thoracotomy due to their compromised health status. The Management of these mTEF patients remain a significant challenge.This study aimed to evaluate the safety and efficacy of using a cardiac septal occluder for the closure of mTEF.
    METHODS: 8 patients with mTEF underwent closure surgery using atrial/ventricular septal defect (ASD/VSD) septal occluders at the Respiratory Department of HuBei Yichang Central People\'s Hospital from 2021 to 2023. The procedure involved percutaneous placement of the occluder through the fistula to achieve closure.
    RESULTS: The placement of the cardiac septal occluder was successfully achieved with ease and efficiency in all patients. The study demonstrated that the use of cardiac septal occluder therapy in patients with mTEF can alleviate symptoms, improve quality of life, and enhance survival rates, with no significant complications observed. Furthermore, the study provided comprehensive details on surgical indications, preoperative evaluation and diagnosis, selection of occluder, methods of occlusion, and postoperative care.
    CONCLUSIONS: The application of cardiac septal occluder in the treatment of mTEF is a safe and effective palliative treatment. This approach may be particularly beneficial for patients with a high risk of complications and mortality associated with traditional surgical interventions.
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  • 文章类型: Journal Article
    背景:先前的研究已经验证了磁压缩和手术技术在创建兔气管食管瘘(TEF)模型中的有效性。磁压缩达到100%的成功率,但需要更多的时间,手术时,虽然不太成功,在大型动物模型中提供快速模型建立和技术成熟。
    目的:确定兔疾病建模的最佳方法并完善过程。
    方法:使用改良的磁压缩技术和手术在12只兔子中创建TEF模型。模型建立时间的比较,成功率,食物和水的摄入,体重变化,活动水平,支气管镜检查结果,白细胞计数,并进行了活检。响应在修改的磁压缩建模过程中遇到的故障,我们将样本量增加到15只兔子模型,并评估了模型的可重复性和稳定性,将它们与原始的磁压缩技术进行比较。
    结果:改进的磁压缩技术获得了66.7%的成功率,而手术技术的成功率为33.3%。由于TEF相关的炎症,存活的手术兔可能无法满足随后的实验要求。在改良的磁压缩组中,一只兔子死了,可能是由于磁铁腐蚀,还有一个人死于气管磁铁阻塞.在第二轮修改的磁压缩建模过程中也发生了类似的事件,一只兔子可能死于加重的肺部感染。第一轮改良磁压操作时间为3.2±0.6min,在第二轮中明显减少到2.1±0.4分钟,与第一轮和原始技术相比。
    结论:改进的磁压缩技术表现出较低的应力响应,一个简单的程序,成功率很高,更低的建模成本,使其成为构建兔TEF模型的更合适的选择。
    BACKGROUND: Previous studies have validated the efficacy of both magnetic compression and surgical techniques in creating rabbit tracheoesophageal fistula (TEF) models. Magnetic compression achieves a 100% success rate but requires more time, while surgery, though less frequently successful, offers rapid model establishment and technical maturity in larger animal models.
    OBJECTIVE: To determine the optimal approach for rabbit disease modeling and refine the process.
    METHODS: TEF models were created in 12 rabbits using both the modified magnetic compression technique and surgery. Comparisons of the time to model establishment, success rate, food and water intake, weight changes, activity levels, bronchoscopy findings, white blood cell counts, and biopsies were performed. In response to the failures encountered during modified magnetic compression modeling, we increased the sample size to 15 rabbit models and assessed the repeatability and stability of the models, comparing them with the original magnetic compression technique.
    RESULTS: The modified magnetic compression technique achieved a 66.7% success rate, whereas the success rate of the surgery technique was 33.3%. Surviving surgical rabbits might not meet subsequent experimental requirements due to TEF-related inflammation. In the modified magnetic compression group, one rabbit died, possibly due to magnet corrosion, and another died from tracheal magnet obstruction. Similar events occurred during the second round of modified magnetic compression modeling, with one rabbit possibly succumbing to aggravated lung infection. The operation time of the first round of modified magnetic compression was 3.2 ± 0.6 min, which was significantly reduced to 2.1 ± 0.4 min in the second round, compared to both the first round and that of the original technique.
    CONCLUSIONS: The modified magnetic compression technique exhibits lower stress responses, a simple procedure, a high success rate, and lower modeling costs, making it a more appropriate choice for constructing TEF models in rabbits.
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  • 文章类型: Journal Article
    对于复杂的食管闭锁患者,磁压缩吻合术是一种有前途的治疗选择;但是,目前,在外科医生可以在可接受的张力下对食道两端进行初次吻合的情况下,不应是首选治疗选择。
    Magnetic compression anastomosis is a promising treatment option for patients with complex esophageal atresia; but, at the present time, should not be the first therapeutic option in those cases where the surgeon can perform a primary anastomosis of the two ends of the esophagus with acceptable tension.
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  • 文章类型: Case Reports
    纽扣电池摄入一直是耳鼻喉科医师遇到的常见情况。食管的撞击可导致严重和致命的并发症,例如气管食管瘘。管理涉及多学科团队,从支持治疗到手术干预各不相同。
    在过去的十年中,人们看到纽扣电池的摄入频率越来越高。在少数报告的病例中,它们在食道中的撞击导致了严重的,有时是致命的,并发症。这些病例的管理与预期不同,早期手术干预的支持疗法。我们报告了一例纽扣电池摄入的病例,该病例被诊断为晚期,并导致气管食管瘘的并发症,并通过开放手术进行了处理。
    UNASSIGNED: Button battery ingestion has been a common condition encountered by otorhinolaryngologists. Impaction in the esophagus can lead to serious and fatal complications such as tracheoesophageal fistula. Management involves a multidisciplinary team and varies from supportive therapy to surgical intervention.
    UNASSIGNED: Ingestion of button batteries has been seen with increasing frequency over the past decade. In several small numbers of reported cases, their impaction in the esophagus has led to severe, sometimes fatal, complications. The management of these cases has varied from expectant, supportive therapy to early surgical intervention. We report a case of button battery ingestion that was diagnosed late and resulted in a complication of tracheoesophageal fistula with migration to the thorax which was managed by open surgery.
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  • 文章类型: Case Reports
    背景:获得性非恶性气管食管瘘(TEF)是一种罕见的气管和食管之间的病理连接,主要由医源性损伤引起。袖口相关损伤导致气管食管壁压力性坏死,通常是由于管子的过度膨胀。
    方法:一名机械通气3个月的29岁男性在断奶后出现TEF。病人有严重的败血症,右下叶肺炎,和肺炎旁积液需要多学科方法管理。采用了术前措施,包括控制败血症,营养支持,胃减压,肺物理治疗,将袖带放置在瘘管远端,从通风中断奶。我们使用外侧入路用插入绑带肌皮瓣进行了一期TEF修复。
    结论:手术方式很大程度上取决于瘘管的位置,尺寸,并伴有气管狭窄.大的TEF或气管狭窄通过分段气管切除和吻合来修复。小TEF和正常气管直接闭合气管和食管缺损,可以通过外侧或前宫颈切开术进行。
    结论:这个案例强调了多学科方法的重要性,术前管理,和细致的手术技术在获得性TEF的管理中。
    BACKGROUND: Acquired non-malignant tracheoesophageal fistula (TEF) is a rare pathological connection between the trachea and esophagus caused primarily by iatrogenic injuries. Cuff-related injury causes pressure necrosis of the tracheoesophageal walls, often due to the overinflation of tubes.
    METHODS: A 29-year-old male who was mechanically ventilated for 3 months developed TEF after weaning from ventilation. The patient had severe sepsis, right lower lobe pneumonia, and parapneumonic effusion requiring multidisciplinary approach management. Preoperative measures were applied, including control of sepsis, nutritional support, stomach decompression, lung physiotherapy, placement of the cuff distal to the fistula, and weaning from ventilation. We performed a one-stage TEF repair with an interposition strap muscle flap using the lateral approach.
    CONCLUSIONS: The surgical approach greatly depends on the fistula location, size, and concomitant tracheal stenosis. Large TEFs or tracheal stenosis are repaired with segmental tracheal resection and anastomosis. Small TEFs and a normal trachea are repaired with direct closure of tracheal and esophageal defects, which can be performed through lateral or anterior cervicotomy.
    CONCLUSIONS: This case emphasizes the importance of a multidisciplinary approach, preoperative management, and meticulous surgical technique in the management of acquired TEF.
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  • 文章类型: Journal Article
    我们开发了一种3D打印的胸腔镜手术模拟器,用于食管闭锁伴气管食管瘘(EA-TEF),并评估了其在教育年轻儿科外科医生方面的有效性。在生产基于患者术前胸部计算机断层扫描的3D打印最终产品之前,原型生产和修改重复五次。对模拟器进行了24项调查,改编自以前的一份报告,与16名年轻的外科医生,平均6.2年的儿科手术经验进行验证。胸廓的可重复使用部分被打印以与可更换部分组合。每个结构都是使用不同的印刷材料制造的,并随后固定在框架上。在评估模拟器时,各因子得分分别为4.33、4.33、4.27、4.31、4.63和4.75,具有最高的价值和相关性评级。全球评级为4分之3.38,有10分表示可以在略有改进的情况下使用。参与者最常见的评论是食管吻合术接近实际的EA-TEF手术。开发了3D打印胸腔镜EA-TEF手术模拟器,并反映了实际的手术环境。它可以成为培训年轻儿科外科医生的有效方法。
    We developed a 3D-printed thoracoscopic surgery simulator for esophageal atresia with tracheoesophageal fistula (EA-TEF) and assessed its effectiveness in educating young pediatric surgeons. Prototype production and modifications were repeated five times before producing the 3-D printed final product based on a patient\'s preoperative chest computed tomography. A 24-item survey was used to rate the simulator, adapted from a previous report, with 16 young surgeons with an average of 6.2 years of experience in pediatric surgery for validation. Reusable parts of the thoracic cage were printed to combine with replaceable parts. Each structure was fabricated using diverse printing materials, and subsequently affixed to a frame. In evaluating the simulator, the scores for each factor were 4.33, 4.33, 4.27, 4.31, 4.63, and 4.75 out of 5, respectively, with the highest ratings in value and relevance. The global rating was 3.38 out of 4, with ten stating that it could be used with slight improvements. The most common comment from participants was that the esophageal anastomosis was close to the actual EA-TEF surgery. The 3D-printed thoracoscopic EA-TEF surgery simulator was developed and reflected the actual surgical environment. It could become an effective method of training young pediatric surgeons.
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  • 文章类型: Case Reports
    H型气管食管瘘是一种罕见的先天性异常,由食管和气管之间的异常通道组成,没有食管闭锁。这种情况通常在婴儿期早期发现;然而,一些患者可能接受延迟诊断。H型气管食管瘘患者的症状差异很大,可能包括吞咽液体时咳嗽发作和下呼吸道感染复发。最常用的初始诊断测试可能会产生错误的阴性结果。大多数H型气管食管瘘的治疗选择是开放外科手术;然而,在瘘管位于胸腔出口下方的情况下,胸腔镜方法已被证明是有效的。在这个案例报告中,我们描述了一例H型气管食管瘘的诊断延迟了13年,并通过胸腔镜手术成功治疗的患者.
    An H-type tracheoesophageal fistula is a rare congenital anomaly consisting of an abnormal passageway between the esophagus and the trachea without the presence of esophageal atresia. This condition is usually detected early in infancy; however, some patients may receive a delayed diagnosis. Symptoms experienced by people affected with an H-type tracheoesophageal fistula vary greatly and may consist of bouts of coughing when swallowing liquids and recurring lower respiratory infections. The most commonly used initial diagnostic tests can produce falsely negative results. The treatment of choice for the majority of H-type tracheoesophageal fistulas is an open surgical procedure; however, the thoracoscopic approach has proven effective in cases where the fistula is located below the thoracic outlet. In this case report, we describe a patient whose diagnosis of H-type tracheoesophageal fistula was delayed by 13 years and who was successfully treated using thoracoscopic surgery.
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  • 文章类型: Journal Article
    背景:磁压缩技术已用于建立气管食管瘘(TEF)的动物模型,但是普通形状的磁体存在TEF的差的均匀性和差的模型控制的限制。我们设计了一个T形磁体系统来克服这些问题,并通过动物实验验证了其有效性。
    目的:研究T形磁体系统在建立比格犬TEF模型中的有效性。
    方法:将12只小猎犬随机分配到T形方案的磁铁组(研究组,n=6)或正常磁铁(对照组,n=6)在胃镜下分别植入气管和食道。操作时间,手术成功率,并记录了意外伤害。手术后,观察咳嗽的存在和时间以及磁铁脱落的时间。对照组犬在咳嗽后经X线和胃镜检查后安乐死,以确认建立TEFs,并获得了TEF的总标本。研究组犬在术后2周进行X线和胃镜检查后实施安乐死,并获得了大体标本。测量所有动物的瘘管大小,然后用苏木精和伊红(HE)和Masson三色染色检查采集的瘘管标本。
    结果:两组手术成功率均为100%。研究组手术时间(5.25min±1.29min)与对照组(4.75min±1.70min,P=0.331)差异无统计学意义。没有出血,穿孔,或在手术过程中任何动物都发生了计划外的磁铁吸引。在术后早期,所有的狗都吃得很自由,一般情况都很好。对照组犬术后6~9d饮水后出现剧烈咳嗽。X光显示磁铁已经进入胃部,胃镜检查显示TEF形成。来自对照组的TEF的大体标本显示形成了直径为4.94mm±1.29mm的瘘管(范围,3.52-6.56mm)。HE和Masson三色染色显示瘘管处的疤痕组织形成和分层结构紊乱。研究组犬术后未出现明显咳嗽。术后2周X线检查提示固定磁铁定位,胃镜检查显示磁铁位置无变化。在内窥镜下使用圈套器移除磁体,并观察到TEF。大体标本显示出形状良好的瘘管,直径为6.11mm±0.16mm(范围,5.92-6.36mm),超过对照组(P<0.001)。通过HE和Masson三色染色在瘘管内表面观察到疤痕形成。结构比对照组更有规律。
    结论:使用改良的T形磁体方案对于建立TEF是安全可行的,与普通磁体相比,可以实现更稳定,更均匀的瘘管尺寸。最重要的是,该模型提供了更好的可控性,这提高了后续研究的灵活性。
    BACKGROUND: The magnetic compression technique has been used to establish an animal model of tracheoesophageal fistula (TEF), but the commonly shaped magnets present limitations of poor homogeneity of TEF and poor model control. We designed a T-shaped magnet system to overcome these problems and verified its effectiveness via animal experiments.
    OBJECTIVE: To investigate the effectiveness of a T-shaped magnet system for establishing a TEF model in beagle dogs.
    METHODS: Twelve beagles were randomly assigned to groups in which magnets of the T-shaped scheme (study group, n = 6) or normal magnets (control group, n = 6) were implanted into the trachea and esophagus separately under gastroscopy. Operation time, operation success rate, and accidental injury were recorded. After operation, the presence and timing of cough and the time of magnet shedding were observed. Dogs in the control group were euthanized after X-ray and gastroscopy to confirm establishment of TEFs after coughing, and gross specimens of TEFs were obtained. Dogs in the study group were euthanized after X-ray and gastroscopy 2 wk after surgery, and gross specimens were obtained. Fistula size was measured in all animals, and then harvested fistula specimens were examined by hematoxylin and eosin (HE) and Masson trichrome staining.
    RESULTS: The operation success rate was 100% for both groups. Operation time did not differ between the study group (5.25 min ± 1.29 min) and the control group (4.75 min ± 1.70 min; P = 0.331). No bleeding, perforation, or unplanned magnet attraction occurred in any animal during the operation. In the early postoperative period, all dogs ate freely and were generally in good condition. Dogs in the control group had severe cough after drinking water at 6-9 d after surgery. X-ray indicated that the magnets had entered the stomach, and gastroscopy showed TEF formation. Gross specimens of TEFs from the control group showed the formation of fistulas with a diameter of 4.94 mm ± 1.29 mm (range, 3.52-6.56 mm). HE and Masson trichrome staining showed scar tissue formation and hierarchical structural disorder at the fistulas. Dogs in the study group did not exhibit obvious coughing after surgery. X-ray examination 2 wk after surgery indicated fixed magnet positioning, and gastroscopy showed no change in magnet positioning. The magnets were removed using a snare under endoscopy, and TEF was observed. Gross specimens showed well-formed fistulas with a diameter of 6.11 mm ± 0.16 mm (range, 5.92-6.36 mm), which exceeded that in the control group (P < 0.001). Scar formation was observed on the internal surface of fistulas by HE and Masson trichrome staining, and the structure was more regular than that in the control group.
    CONCLUSIONS: Use of the modified T-shaped magnet scheme is safe and feasible for establishing TEF and can achieve a more stable and uniform fistula size compared with ordinary magnets. Most importantly, this model offers better controllability, which improves the flexibility of follow-up studies.
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