除了它在铁代谢中的核心作用,在各种血液系统疾病中,红细胞转铁蛋白(ERFE)已成为具有深远影响的关键参与者.其对铁调素的调节作用强调了其在以铁稳态破坏为特征的条件下的重要性。在β-地中海贫血和骨髓增生异常综合征中,它的失调错综复杂地导致了贫血和铁超负荷的临床挑战,这凸显了它作为治疗靶点的潜力。在慢性病贫血和缺铁性贫血中,ERFE提供了一个独特的配置文件。在慢性肾脏病(CKD)中,ERFE之间复杂的相互作用,促红细胞生成素,铁调素失调,导致这种情况下复杂的铁不平衡特征。最近的研究表明,ERFE在恢复CKD中铁平衡中起着多方面的作用,不仅仅是抑制铁调素的产生。调节ERFE活性的潜力提供了治疗与铁失调相关的一系列疾病的新方法。随着我们对ERFE的理解不断发展,它有望成为靶向治疗发展的重点,使其成为正在进行的研究的一个令人兴奋和充满活力的领域。调节ERFE活性提出了一种开创性的方法来治疗缺铁性贫血等疾病中的铁失调,地中海贫血,和血色素沉着症。随着新研究揭示其错综复杂的角色,ERFE已迅速成为开发靶向疗法如ERFE激动剂和拮抗剂的关键靶标。随着有希望的研究正在进行,这个动态领域具有改善患者预后的巨大潜力,减少并发症,并在血液学研究中提供个性化的治疗方案。对ERFE在各种条件下的作用的全面概述强调了其在铁代谢和相关病理中的关键作用。
Beyond its core role in iron metabolism, erythroferrone (ERFE) has emerged as a key player with far-reaching implications in various hematologic disorders. Its regulatory effect on hepcidin underlines its significance in conditions characterized by disrupted iron homeostasis. In β-thalassemia and myelodysplastic syndromes, its dysregulation intricately contributes to the clinical challenges of anemia and iron overload which highlights its potential as a therapeutic target. In anemia of chronic disease and iron deficiency anemia, ERFE presents a unique profile. In chronic kidney disease (CKD), the intricate interplay between ERFE, erythropoietin, and hepcidin undergoes dysregulation, contributing to the complex iron imbalance characteristic of this condition. Recent research suggests that ERFE plays a multifaceted role in restoring iron balance in CKD, beyond simply suppressing hepcidin production. The potential to modulate ERFE activity offers a novel approach to treating a spectrum of disorders associated with iron dysregulation. As our understanding of ERFE continues to evolve, it is poised to become a key focus in the development of targeted treatments, making it an exciting and dynamic area of ongoing research. Modulating ERFE activity presents a groundbreaking approach to treat iron dysregulation in conditions like iron deficiency anemia, thalassemia, and hemochromatosis. As new research unveils its intricate roles, ERFE has rapidly emerged as a key target for developing targeted therapies like ERFE agonists and antagonists. With promising studies underway, this dynamic field holds immense potential to improve patient outcomes, reduce complications, and offer personalized treatment options in hematology research. This comprehensive overview of ERFE\'s role across various conditions underscores its pivotal function in iron metabolism and associated pathologies.