PDF(Pubmed)
Abstract：
This literature review emphasizes the innovative role of ferroptosis in cancer treatment. Ferroptosis is a kind of deliberate cell death that is characterized by the generation of lipid peroxides and needs the presence of iron. Ferroptosis is a controlled cell death process that adheres to certain rules and regulations. The inhibition of System Xc- and the involvement of GPX4 are two of the primary areas of exploration that are engaged in the process of ferroptosis. This review explores the treatments that are used to treat ferroptosis in a range of malignancies, with a particular focus on breast carcinoma. Attention is paid to certain pathways, such as the FSP1-independent regulation of glutathione, involvement of cholesterol, and the prominin 2-MVB/exosome-ferritin pathway. Ferroptosis plays a key role in resistance to tumor therapy.
摘要：
这篇文献综述强调了铁性凋亡在癌症治疗中的创新作用。Ferroptosis是一种故意的细胞死亡，其特征在于脂质过氧化物的产生并且需要铁的存在。Ferroptosis是一种受控的细胞死亡过程，遵守某些规则和规定。系统Xc-的抑制和GPX4的参与是参与铁死亡过程的两个主要探索领域。这篇综述探讨了用于治疗一系列恶性肿瘤中的铁性凋亡的治疗方法。特别关注乳腺癌。注意某些途径，例如谷胱甘肽的FSP1独立调节，胆固醇的参与，和突出蛋白2-MVB/外泌体-铁蛋白途径。Ferroptosis在抵抗肿瘤治疗中起关键作用。
