■癌症相关成纤维细胞(CAF)代表肿瘤微环境(TME)中的主要基质成分,表现出相当大的异质性和可塑性,显著影响TME内的免疫反应和代谢重编程,从而影响肿瘤进展。因此,调查CAF至关重要。这项研究的目的是采用文献计量分析,以评估CAF的研究现状,并预测未来的研究领域和新兴趋势。
■全面搜索WebofScienceCoreCollection数据库中的学术出版物,涵盖从2001年1月1日至2022年12月31日的时间段。应用VOSviewer,CiteSpace,R软件和MicrosoftExcel用于文献计量分析和可视化。
这项研究涉及对79个国家/地区的4,978个机构的33,628名个人撰写的5,925种出版物的综合分析。这些出版物发表在908种期刊上,涵盖14,495个关键词和203,947个参考文献。值得注意的是,2019年至2022年发表的文章大幅增加。中国的文章数量最多,而美国成为最常被引用的国家。该领域的主要研究机构是上海交通大学,哈佛大学,和德克萨斯大学MD安德森癌症中心。索吉亚,Federica和Lisanti,曼彻斯特大学的MichaelP,和Martinet,安特卫普大学的Wim是最多产和被引用最多的作者。《癌症》杂志的出版物数量最多,而癌症研究是最常被引用的期刊。分子,生物学免疫学,医学和遗传学是CAFs领域的主要研究学科。CAFs研究的主要方向包括转化生长因子-β的研究,成纤维细胞激活蛋白,乳腺癌,以及生长和转移。关键词共现和文献共引分析的发现揭示了CAF领域的几个新兴热点和趋势。这些包括STAT3,多药耐药性,胰腺导管腺癌,泛癌症分析,临床前评估,电离辐射,和金纳米粒子。
■靶向CAFs有望成为一种新颖有效的癌症治疗策略。本研究利用文献计量学分析,全面概述了2001年至2022年对CAF的现有研究。该研究确定了突出的调查领域,并预期了未来的研究方向,目的是为未来CAF领域的研究提供有价值的见解和建议。
Cancer-associated fibroblasts (CAFs) represent the predominant stromal component within the tumour microenvironment (TME), exhibiting considerable heterogeneity and plasticity that significantly impact immune response and metabolic reprogramming within the TME, thereby influencing tumour progression. Consequently, investigating CAFs is of utmost importance. The objective of this study is to employ bibliometric analysis in order to evaluate the current state of research on CAFs and predict future areas of research and emerging trends.
Conduct a comprehensive search for scholarly publications within the Web of Science Core Collection database, encompassing the time period from January 1, 2001, to December 31, 2022. Apply VOSviewer, CiteSpace, R software and Microsoft Excel for bibliometric analysis and visualisation.
This study involved a comprehensive analysis of 5,925 publications authored by 33,628 individuals affiliated with 4,978 institutions across 79 countries/regions. These publications were published in 908 journals, covering 14,495 keywords and 203,947 references. Notably, there was a significant increase in articles published between 2019 and 2022. China had the highest count of articles, while the United States emerged as the most frequently cited country. The primary research institutions in this field were Shanghai Jiao Tong University, Harvard University, and the University of Texas MD Anderson Cancer Center. Sotgia, Federica and Lisanti, Michael P from the University of Manchester, and Martinet, Wim from the University of Antwerp were the most prolific and highly cited authors. The journal Cancers had the highest number of publications, while Cancer Research was the most frequently cited journal. Molecular, biology, immunology, medicine and genetics were the main research disciplines in the field of CAFs. Key directions in CAFs research encompassed the study of transforming growth factor-β, Fibroblast Activation Protein, breast cancer, as well as growth and metastasis. The findings from the analysis of keyword co-occurrence and literature co-citation have revealed several emerging hotspots and trends within the field of CAFs. These include STAT3, multidrug resistance, pancreatic ductal adenocarcinoma, pan-cancer analysis, preclinical evaluation, ionizing radiation, and gold nanoparticles.
Targeting CAFs is anticipated to be a novel and effective strategy for cancer treatment. This study provides a comprehensive overview of the existing research on CAFs from 2001 to 2022, utilizing bibliometric analysis. The study identified the prominent areas of investigation and anticipated future research directions, with the aim of providing valuable insights and recommendations for future studies in the field of CAFs.