■尽管高血压对颈动脉内膜中膜厚度(IMT)和斑块的影响已得到很好的证实,尚未广泛检查其与股骨IMT和斑块的相关性。此外,收缩压和舒张压比值(SDR)在亚临床动脉粥样硬化(AS)风险中的作用尚不清楚.我们评估了一般人群中SDR与颈动脉和股动脉粥样硬化之间的关系。
从2019年1月至2021年6月,在中国东南部地区共招募了7,263名35-74岁的参与者,纳入了横断面研究。收缩压和舒张压(SBP和DBP)用于定义SDR。超声检查用于评估AS,包括增厚的IMT(TIMT)和斑块在颈动脉和股动脉。Logistic回归和有限三次样条(RCS)模型是主要方法。
■TIMT的患病率,牌匾,AS为17.3%,12.4%,颈动脉占22.7%;15.2%,10.7%,股动脉占19.5%;23.8%,颈动脉或股动脉分别为17.9%和30.0%,分别。多变量逻辑回归分析发现,高三元组SDR与总体TIMT的高风险之间存在显着正相关(OR=1.28,95%CI=1.10-1.49),斑块(OR=1.36,95CI=1.16-1.61),或AS(OR=1.36,95%CI=1.17-1.57),尤其是颈动脉.RCS分析进一步显示观察到的正相关是线性的。进一步的分析表明,与低三分位数SDR和非高血压组相比,高三元组SDR与总体和颈动脉TIMT风险增加相关,斑块,或AS在两组有或没有高血压。
■SDR与亚临床AS的高风险有关,不管是否有高血压,这表明,作为一个容易获得的指数,SDR可以为AS提供额外的预测值。
UNASSIGNED: Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with
femoral IMT and plaques has not been extensively examined. In addition, the role of the ratio of systolic and diastolic pressure (SDR) in the subclinical atherosclerosis (AS) risk remains unknown. We assessed the relationship between SDR and carotid and
femoral AS in a general population.
UNASSIGNED: A total of 7,263 participants aged 35-74 years enrolled from January 2019 to June 2021 in a southeast region of China were included in a cross-sectional study. Systolic and diastolic blood pressure (SBP and DBP) were used to define SDR. Ultrasonography was applied to assess the AS, including thickened IMT (TIMT) and plaque in the carotid and
femoral arteries. Logistic regression and restricted cubic spline (RCS) models were the main approaches.
UNASSIGNED: The prevalence of TIMT, plaque, and AS were 17.3%, 12.4%, and 22.7% in the carotid artery; 15.2%, 10.7%, and 19.5% in the
femoral artery; and 23.8%, 17.9% and 30.0% in either the carotid or
femoral artery, respectively. Multivariable logistic regression analysis found a significant positive association between high-tertile SDR and the higher risk of overall TIMT (OR = 1.28, 95% CI = 1.10-1.49), plaques (OR = 1.36, 95%CI = 1.16-1.61), or AS (OR = 1.36, 95% CI = 1.17-1.57), especially in the carotid artery. RCS analysis further revealed the observed positive associations were linear. Further analyses showed that as compared to the low-tertile SDR and non-hypertension group, high-tertile SDR was associated with increased risks of overall and carotid TIMT, plaques, or AS in both groups with or without hypertension.
UNASSIGNED: SDR is related to a higher risk of subclinical AS, regardless of hypertension or not, suggesting that as a readily obtainable index, SDR can contribute to providing additional predictive value for AS.