■子宫内膜息肉(EP)是最常见的宫内良性肿瘤之一,是子宫出血和女性不孕的重要原因。先前的研究表明,子宫内膜炎可能有助于EP的发作。本研究旨在通过双样本孟德尔随机(MR)研究揭示子宫内膜炎对EP的因果影响。
■利用欧洲人群全基因组关联研究(GWAS)的汇总统计数据,我们进行了孟德尔随机化研究.为了选择与暴露量显著相关的合适工具变量(IV),使用了许多质量控制方法。对于子宫内膜炎,包括2144例病例和111,858例对照,而对于EP来说,2252例病例和460,758例对照。利用逆方差加权(IVW)作为主要分析,对数据进行了双样本MR分析,并进行了加权中位数(WM)技术和MR-Egger回归。敏感性分析既没有异质性,也没有水平多效性。
■选择来自子宫内膜炎GWAS的四个独立的单核苷酸多态性(SNPs)作为IVs。IVW数据与子宫内膜炎和EP之间的因果关系不一致(β=1.11e-04,标准误差[SE]=4.88e-04,P=0.82)。定向多效并不影响结果,根据MR-Egger回归(截距=0.09,P=0.10);此外,它显示子宫内膜炎和EP之间没有因果关系(β=-3.28e-03,SE=3.54e-03,P=0.45)。使用加权中位数方法获得了类似的结果(β=8.56e-05,SE=5.97e-04,P=0.89)。没有发现IV估计之间的异质性和水平多效性的证据。
■总而言之,通过大规模的遗传数据,这项MR分析的结果提供了提示证据,表明子宫内膜炎的存在与更高的EP风险无关.
UNASSIGNED: Endometrial polyps (EPs) are one of the most common intrauterine benign tumors, and are an important cause of uterine bleeding and female infertility. Previous studies have suggested that endometritis may contribute to the onset of EPs. This study aims to reveal the causal effect of endometritis on EPs by a two-sample Mendelian randomization (MR) study.
UNASSIGNED: Utilizing summarized statistics from genome-wide association studies (GWAS) in the European population, we conducted a Mendelian randomization study. In order to select suitable instrumental variables (IVs) that were significantly related to the exposures, a number of quality control approaches were used. For endometritis, 2144 cases and 111,858 controls were included, while for EPs, 2252 cases and 460,758 controls. Utilizing the inverse variance weighted (IVW) as the primary analysis, the data were subjected to a two-sample MR analysis, and the weighted median (WM) technique and MR-Egger regression were carried out additionally. The sensitivity analysis revealed neither heterogeneity nor horizontal pleiotropy.
UNASSIGNED: Four independent single nucleotide polymorphisms (SNPs) from endometritis GWAS as IVs were selected. The IVW data did not agree to a causal association between endometritis and EPs (β=1.11e-04, standard error [SE] =4.88e-04, P = 0.82). Directional pleiotropy did not affect the outcome, according to the MR-Egger regression (intercept = 0.09, P = 0.10); Additionally, it showed no causation association between endometritis and EPs (β= -3.28e-03, SE = 3.54e-03, P = 0.45). Similar results were obtained using the weighted-median method (β=8.56e-05, SE=5.97e-04, P = 0.89). No proof of heterogeneity and horizontal pleiotropy between IV estimates was discovered.
UNASSIGNED: In conclusion, by large scale genetic data, the results of this MR analysis provided suggestive evidence that the presence of endometritis is not associated with higher EPs risk.