PDF(Pubmed)
Abstract：
Introduction Uterine masses are commonly submitted for frozen section, to guide the surgeon, regarding the type and extent of the procedure during surgery. Despite the technical difficulties in processing, sectioning, and staining of frozen section samples, it remains a fairly reliable intraoperative tool. Aim This study aims to analyze the diverse spectrum of uterine masses sent for frozen sections for two years. In addition, it aims to analyze the histomorphology of the uterine masses sent for the frozen section and correlate it with that of the routine histopathological findings, thereby justifying the diagnostic value of the frozen section with this study. Furthermore, the study aims to classify the lesions into benign and malignant, quantify their frequency, and list the most common lesions seen in the uterine mass specimens sent for frozen section analysis. Methodology This retrospective descriptive study includes data from January 2021 to December 2022, retrieved from the archives of the Department of Pathology at Saveetha Medical College. This study includes a total of 76 cases, including all the uterine masses sent for frozen section analysis during the study period. Results Of the total of 76 cases received, 17 (22.4%) were malignant and 59 (77.6%) were benign. Of the malignant cases reported, the most common was endometrial carcinoma, and the least common entities encountered were carcinosarcoma and leiomyosarcoma. Of the benign cases, benign endometrial polyp was the most common endometrial lesion and leiomyoma with and without degeneration was the most common myometrial lesion encountered. Of the 50 cases of leiomyoma encountered, 16 had extensive degenerative changes. The most common degeneration seen in the fibroid was hyaline degeneration, and the least common was xanthogranulomatous degeneration. Conclusions The intraoperative frozen section analysis is a very important diagnostic tool, but we need to be aware of its limitations. The accuracy, sensitivity, and specificity rates were found to be high. Thus, frozen section diagnoses can be very valuable in the clinical management of uterine tumors. Careful gross examination, sampling from representative areas, and good communication between the pathologist and surgeon may help in avoiding its limitations.
摘要：
引言子宫肿块通常提交冷冻切片，指导外科医生，关于手术过程的类型和范围。尽管在加工方面存在技术困难，切片,和冷冻切片样本的染色，它仍然是一个相当可靠的术中工具。目的本研究旨在分析冷冻切片发送的子宫肿块的不同范围。此外,它旨在分析送去冷冻切片的子宫肿块的组织形态学，并将其与常规组织病理学结果相关联，从而证明本研究对冷冻切片的诊断价值。此外，这项研究旨在将病变分为良性和恶性，量化它们的频率，并列出送冰冻切片分析的子宫肿块标本中最常见的病变。方法这项回顾性描述性研究包括2021年1月至2022年12月的数据，这些数据是从Saveetha医学院病理学系的档案中检索的。这项研究共包括76例，包括研究期间送去冷冻切片分析的所有子宫肿块。结果共收到76例病例,恶性17例（22.4%），良性59例（77.6%）。在报告的恶性病例中，最常见的是子宫内膜癌,最不常见的实体是癌肉瘤和平滑肌肉瘤。在良性病例中，良性子宫内膜息肉是最常见的子宫内膜病变，有变性和无变性的平滑肌瘤是最常见的子宫肌层病变。在50例平滑肌瘤中，16有广泛的退行性变化。纤维瘤中最常见的变性是透明变性，最不常见的是黄色肉芽肿变性。结论术中冰冻切片分析是一种非常重要的诊断手段,但是我们需要意识到它的局限性。准确性,灵敏度,发现特异性率高。因此，冰冻切片诊断在子宫肿瘤的临床治疗中非常有价值。仔细的粗略检查，从代表性地区抽样，病理学家和外科医生之间的良好沟通可能有助于避免其局限性。
