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Abstract：
Background/Objectives: This study investigates the correlation between the serum levels of Sestrin 2 and the presence of endometrial polyps or uterine leiomyomas, aiming to enhance the understanding of the pathophysiology underlying these gynecological conditions and evaluate the potential of Sestrin 2 as an early diagnostic biomarker. Methods: In a prospective case-control format, patients with preliminary diagnoses of endometrial polyps or uterine leiomyomas confirmed by histopathological analysis following surgery were included. This study analyzed serum Sestrin 2 levels across different patient groups, revealing significant variations that underscore the diagnostic value of Sestrin 2. Results: Elevated serum Sestrin 2 levels were observed in patients with endometrial polyps and uterine leiomyomas compared to the control group, suggesting its utility as a novel marker for early detection. Conclusions: The study indicates the promising role of serum Sestrin 2 levels as a valuable biomarker for early diagnosis of endometrial polyps and uterine leiomyomas, advocating for further research into its diagnostic and therapeutic potential.
摘要：
背景/目的：本研究探讨血清Sestrin2水平与子宫内膜息肉或子宫肌瘤的相关性。旨在增强对这些妇科疾病的病理生理学的理解，并评估Sestrin2作为早期诊断生物标志物的潜力。方法：以前瞻性病例对照形式，包括手术后通过组织病理学分析证实的初步诊断为子宫内膜息肉或子宫平滑肌瘤的患者.这项研究分析了不同患者组的血清Sestrin2水平，揭示了显著的变化，强调了Sestrin2的诊断价值。结果:子宫内膜息肉和子宫肌瘤患者血清Sestrin2水平较对照组升高,表明它作为早期检测的新型标记物的实用性。结论：该研究表明，血清Sestrin2水平可作为子宫内膜息肉和子宫肌瘤早期诊断的有价值的生物标志物。倡导进一步研究其诊断和治疗潜力。
