背景:在慢性肾脏病(CKD)中,由于肾功能异常,在隔膜中观察到病理变化。已建议对CKD患者进行吸气肌肉训练(IMT);然而,尚未确定IMT的最合适强度。因此,本研究旨在探讨不同IMT方案对呼吸肌力的影响,股四头肌肌力(QMS),手握肌肉力量(HGS),功能性运动能力,生活质量(QoL),肺功能,呼吸困难,疲劳,balance,CKD患者的体力活动(PA)水平。
方法:这是随机的,控制,单盲研究包括47例患者,他们分为三组:第1组(n=15,IMT,最大吸气压力(MIP)为10%),第2组(n=16,IMT,MIP为30%),和第3组(n=16;具有60%MIP的IMT)。MIP,最大呼气压(MEP),6分钟步行试验(6-MWT),QMS,HGS,QoL,肺功能,呼吸困难,疲劳,balance,在IMT前后8周进行PA水平评估。
结果:MIP增加,%MIP,6-MWT距离,IMT后第2组和第3组的6-MWT和%显著高于第1组(p<0.05)。MEP,%MEP,FEF25-75%,QMS,HGS,和QoL显著增加;呼吸困难和疲劳在所有组(p<0.05)。FVC,PEF,PA仅在第2组中改善,而平衡在第1组和第2组中改善(p<0.05)。
结论:具有30%和60%MIP的IMT类似地改善了吸气肌肉力量和功能运动能力。30%的IMT在增加PA方面更有效。IMT是增强外周和呼气肌力量的有益方法,呼吸功能,QoL和平衡,减少呼吸困难和疲劳。对于不耐受较高强度的CKD患者,IMT为%30可能是一种选择。
背景:这项研究是回顾性注册的(NCT06401135,06/05/2024)。
BACKGROUND: Pathological changes were observed in the diaphragm due to abnormal renal function in chronic kidney disease (CKD). Inspiratory muscle training (IMT) has been suggested for patients with CKD; however, the most appropriate intensity for IMT has not been determined. Therefore, this study aimed to investigate the effects of different IMT protocols on respiratory muscle strength, quadriceps femoris muscle strength (QMS), handgrip muscle strength (HGS), functional exercise capacity, quality of life (QoL), pulmonary function,
dyspnoea, fatigue, balance, and physical activity (PA) levels in patients with CKD.
METHODS: This randomized, controlled, single-blind study included 47 patients and they were divided into three groups: Group 1 (n = 15, IMT with 10% maximal inspiratory pressure (MIP)), Group 2 (n = 16, IMT with 30% MIP), and Group 3(n = 16; IMT with 60% MIP). MIP, maximal expiratory pressure (MEP), 6-min walking test (6-MWT), QMS, HGS, QoL, pulmonary function,
dyspnoea, fatigue, balance, and PA levels were assessed before and after eight weeks of IMT.
RESULTS: Increases in MIP, %MIP, 6-MWT distance, and %6-MWT were significantly higher in Groups 2 and 3 than in Group 1 after IMT (p < 0.05). MEP, %MEP, FEF25-75%, QMS, HGS, and QoL significantly increased;
dyspnoea and fatigue decreased in all groups (p < 0.05). FVC, PEF, and PA improved only in Group 2, and balance improved in Groups 1 and 2 (p < 0.05).
CONCLUSIONS: IMT with 30% and 60% MIP similarly improves inspiratory muscle strength and functional exercise capacity. IMT with 30% is more effective in increasing PA. IMT is a beneficial method to enhance peripheral and expiratory muscle strength, respiratory function, QoL and balance, and reduce
dyspnoea and fatigue. IMT with %30 could be an option for patients with CKD who do not tolerate higher intensities.
BACKGROUND: This study was retrospectively registered (NCT06401135, 06/05/2024).