PDF(Pubmed)
Abstract：
UNASSIGNED: Pneumothorax can cause distressing breathlessness, however the effect of the accumulated air in the pleural space and its association with diaphragmatic function and symptoms of breathlessness is not well understood. Bendopnoea is an evolving clinical symptom that has been demonstrated as clinically useful in some heart and lung conditions. Whether bendopnoea is present in patients with pneumothorax, and its potential clinical usefulness has not yet been investigated. The PASE study is a pilot study to explore the incidence and clinical relevance of bendopnoea in patients with pneumothorax and may provide better understanding of pneumothorax related dyspnoea.
UNASSIGNED: PASE is a prospective study. Eligible patients are assessed at baseline (pre air drainage/lung reinflation) and in patients whose pneumothorax resolves once the lung has re-expanded (post conservative management or air drainage procedure). Outcome measures include the incidence of bendopnoea, correlation of the associated symptoms (pain and breathlessness) to the severity of bendopnoea and the size of pneumothorax; and correlation with clinical outcome (i.e., response to air drainage/lung reinflation). The study will recruit 50 participants.
UNASSIGNED: This is the first study to explore bendopnoea in patients with pneumothorax. The presence and significance of bendopnoea in relation to clinical and physiological parameters in patients with pneumothorax requires investigation. The findings of this study may further current understanding of dyspnoea related pneumothorax.
UNASSIGNED: Name of the registry: Australia New Zealand Clinical Trial Registry Trial registration number : ACTRN12623001109695p. URL of the trial registry record for this trial : https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386631&isReview=true Date of registration : Registered on 24 October 2023. Funding of the trial : This study has not received grant support. The study is sponsored by the Institute for Respiratory Health, a not-for-profit organisation. Name and contact information for the trial sponsor : Mr Bi Lam; Finance manager. Level 2, 6 Verdun Street, Nedlands, WA 6009. Role of sponsor : The funder is not involved in the planning of the study, gathering, analysing, and interpreting the data, or in preparing the manuscript. Protocol version : 1.
UNASSIGNED: PASE is a prospective study. Eligible patients are assessed at baseline (pre air drainage/lung reinflation) and in patients whose pneumothorax resolves once the lung has re-expanded (post conservative management or air drainage procedure). Outcome measures include the incidence of bendopnoea, correlation of the associated symptoms (pain and breathlessness) to the severity of bendopnoea and the size of pneumothorax; and correlation with clinical outcome (i.e., response to air drainage/lung reinflation). The study will recruit 50 participants.
UNASSIGNED: This is the first study to explore bendopnoea in patients with pneumothorax. The presence and significance of bendopnoea in relation to clinical and physiological parameters in patients with pneumothorax requires investigation. The findings of this study may further current understanding of dyspnoea related pneumothorax.
UNASSIGNED: Name of the registry: Australia New Zealand Clinical Trial Registry Trial registration number : ACTRN12623001109695p. URL of the trial registry record for this trial : https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386631&isReview=true Date of registration : Registered on 24 October 2023. Funding of the trial : This study has not received grant support. The study is sponsored by the Institute for Respiratory Health, a not-for-profit organisation. Name and contact information for the trial sponsor : Mr Bi Lam; Finance manager. Level 2, 6 Verdun Street, Nedlands, WA 6009. Role of sponsor : The funder is not involved in the planning of the study, gathering, analysing, and interpreting the data, or in preparing the manuscript. Protocol version : 1.
摘要：
■气胸会导致呼吸困难，然而，胸膜腔中积聚的空气的影响及其与膈肌功能和呼吸困难症状的关系尚不清楚。Bendopnoea是一种不断发展的临床症状，已被证明在某些心脏和肺部疾病中具有临床作用。气胸患者是否存在弯曲性噪声，其潜在的临床用途尚未得到研究。PASE研究是一项初步研究，旨在探索气胸患者中bendopnoea的发生率和临床相关性，并可能提供对气胸相关呼吸困难的更好理解。
■PASE是一项前瞻性研究。在基线(空气引流前/肺再充气)和一旦肺重新扩张气胸消退的患者(保守管理或空气引流程序后)进行评估。结果措施包括苯丙胺的发生率，相关症状（疼痛和呼吸困难）与弯曲呼吸的严重程度和气胸的大小的相关性；以及与临床结果的相关性（即对空气引流/肺部再充气的反应)。该研究将招募50名参与者。
■这是首次探索气胸患者的神经麻痹的研究。与气胸患者的临床和生理参数相关的苯并不存在和意义需要研究。这项研究的结果可能进一步了解呼吸困难相关的气胸。
■注册管理机构名称：澳大利亚新西兰临床试验注册管理机构试验登记号：ACTRN12623001109695p。此试验的试验注册表记录的URL：https://anzctr.org。au/Trial/Registration/TrialReview.aspx?id=386631&isReview=真实注册日期：2023年10月24日注册。试验资助：本研究尚未获得资助支持。这项研究由呼吸健康研究所赞助，非营利组织。试验发起人的姓名和联系信息：毕林先生；财务经理。凡尔登街6号2楼，内德兰兹,西澳6009.赞助者的角色：资助者不参与研究的计划，聚集,分析,解释数据，或者准备手稿。协议版本:1.
■PASE是一项前瞻性研究。在基线(空气引流前/肺再充气)和一旦肺重新扩张气胸消退的患者(保守管理或空气引流程序后)进行评估。结果措施包括苯丙胺的发生率，相关症状（疼痛和呼吸困难）与弯曲呼吸的严重程度和气胸的大小的相关性；以及与临床结果的相关性（即对空气引流/肺部再充气的反应)。该研究将招募50名参与者。
■这是首次探索气胸患者的神经麻痹的研究。与气胸患者的临床和生理参数相关的苯并不存在和意义需要研究。这项研究的结果可能进一步了解呼吸困难相关的气胸。
■注册管理机构名称：澳大利亚新西兰临床试验注册管理机构试验登记号：ACTRN12623001109695p。此试验的试验注册表记录的URL：https://anzctr.org。au/Trial/Registration/TrialReview.aspx?id=386631&isReview=真实注册日期：2023年10月24日注册。试验资助：本研究尚未获得资助支持。这项研究由呼吸健康研究所赞助，非营利组织。试验发起人的姓名和联系信息：毕林先生；财务经理。凡尔登街6号2楼，内德兰兹,西澳6009.赞助者的角色：资助者不参与研究的计划，聚集,分析,解释数据，或者准备手稿。协议版本:1.
