■心脏病(HD),脑血管疾病(CBD),肾脏疾病(KD)是世界范围内的严重疾病。这些疾病是世界范围内死亡的主要原因,治疗费用昂贵。有必要分析危险因素以预防这些疾病。
■使用从JMDC索赔数据库获得的2,837,334、2,864,874和2,870,262次体检数据对风险因素进行了分析。用于控制高血压的药物(抗高血压药物)的副作用,高血糖(抗高血糖药物),和高胆固醇血症(胆固醇药物),包括他们的互动,也进行了评估。Logit模型用于计算比值比和置信区间。样本期为2005年1月至2019年9月。
■发现年龄和疾病史是非常重要的因素,患病的风险几乎会增加一倍。尿蛋白水平和近期体重的大变化也是这三种疾病的重要因素,并使风险增加10%-30%,除了KD.对于KD,尿蛋白水平高的个体的风险是两倍多.观察到抗高血压药物的副作用,抗高血糖,和胆固醇药物。特别是,当使用抗高血压药物时,HD和CBD的风险几乎增加了一倍.当个体服用抗高血压药物时,KD的风险是三倍。如果他们没有服用抗高血压药物和其他药物,这些值较低(HD的20%-40%,50%-70%的CBD,KD为60%-90%)。不同类型的药物之间的相互作用不是很大。当同时使用抗高血压和胆固醇药物时,在HD和KD病例中,风险显著增加。
■对于具有危险因素的个体来说,改善其身体状况对于预防这些疾病非常重要。服用降压药,抗高血糖,和胆固醇药物,尤其是抗高血压药物,可能是严重的危险因素。特别护理和额外的研究是必要的处方这些药物,特别是抗高血压药物。
■没有进行实验干预。由于数据集包括日本工人的健康检查结果,不包括76岁及以上的个人。由于数据集仅包含在日本获得的信息,而日本人在种族上是同质的,未评估种族对疾病的潜在影响.
UNASSIGNED: Heart disease (HD), cerebrovascular disease (CBD), and kidney disease (KD) are serious diseases worldwide. These diseases constitute the leading causes of death worldwide and are costly to treat. An analysis of risk factors is necessary to prevent these diseases.
UNASSIGNED: Risk factors were analyzed using data from 2,837,334, 2,864,874, and 2,870,262 medical checkups obtained from the JMDC Claims Database. The side effects of medications used to control hypertension (antihypertensive medications), hyperglycemia (antihyperglycemic medications), and hypercholesterolemia (cholesterol medications), including their interactions, were also evaluated. Logit models were used to calculate the odds ratios and confidence intervals. The sample period was from January 2005 to September 2019.
UNASSIGNED: Age and history of diseases were found to be very important factors, and the risk of having diseases could be almost doubled. Urine protein levels and recent large weight changes were also important factors for all three diseases and made the risks 10%-30% higher, except for KD. For KD, the risk was more than double for individuals with high urine protein levels. Negative side effects were observed with antihypertensive, antihyperglycemic, and cholesterol medications. In particular, when antihypertensive medications were used, the risks were almost doubled for HD and CBD. The risk would be triple for KD when individuals were taking antihypertensive medications. If they did not take antihypertensive medications and took other medications, these values were lower (20%-40% for HD, 50%-70% for CBD, and 60%-90% for KD). The interactions between the different types of medications were not very large. When antihypertensive and cholesterol medications were used simultaneously, the risk increased significantly in cases of HD and KD.
UNASSIGNED: It is very important for individuals with risk factors to improve their physical condition for the prevention of these diseases. Taking antihypertensive, antihyperglycemic, and cholesterol medications, especially antihypertensive medications, may be serious risk factors. Special care and additional studies are necessary to prescribe these medications, particularly antihypertensive medications.
UNASSIGNED: No experimental interventions were performed. As the dataset was comprised of the results of health checkups of workers in Japan, individuals aged 76 and above were not included. Since the dataset only contained information obtained in Japan and the Japanese are ethnically homogeneous, potential ethnic effects on the diseases were not evaluated.