这项研究探讨了Biomiel(老年人微量营养素的生物利用度)研究中富含微量营养素的干预餐后餐后微量营养素吸收的年龄和时间依赖性变化。由43名健康参与者组成,该研究比较了年轻人(n=21;平均年龄26.90岁)和老年人(n=22;平均年龄66.77岁)的男性和女性,分析铁(Fe)的基线浓度和餐后六小时动力学,铜(Cu),锌(Zn),硒(Se),碘(I),游离锌(fZn),维生素C,视黄醇,番茄红素,β-胡萝卜素,α-生育酚,和γ-生育酚,以及25(OH)维生素D(仅在基线定量)。方法上,在基线时以及餐后90,180,270和360分钟时对血清或血浆进行定量.结果显示年轻组血清锌和血浆番茄红素浓度较高,而铜,Se,Cu/Zn比,25(OH)维生素D,α-生育酚,老年参与者中γ-生育酚较高。餐后锌的变异性,维生素C,番茄红素表现出强烈的时间依赖性。观察到硒的餐后代谢与年龄相关的差异,Cu,而I.尽管如此,大部分差异是由个性解释的。尽管有一些限制,这项研究提供了对餐后微量营养素代谢(在血清/血浆中)的见解,强调需要进一步研究以全面了解这一复杂领域。我们的发现为设计有针对性的干预措施以解决和减轻老年人的微量营养素缺乏提供了宝贵的见解。在整个生命周期中培养最佳的健康和福祉。
This study explores age- and time-dependent variations in postprandial micronutrient absorption after a micronutrient-rich intervention meal within the Biomiel (bioavailability of micronutrients in elderly) study. Comprising 43 healthy participants, the study compares young (n = 21; mean age 26.90 years) and old (n = 22; mean age 66.77 years) men and women, analyzing baseline concentrations and six-hour postprandial dynamics of iron (Fe), copper (Cu), zinc (Zn), selenium (Se), iodine (I), free zinc (fZn), vitamin C, retinol, lycopene, β-carotene, α-tocopherol, and γ-tocopherol, along with 25(OH) vitamin D (quantified only at baseline). Methodologically, quantifications in serum or plasma were performed at baseline and also at 90, 180, 270, and 360 min postprandially. Results reveal higher baseline serum Zn and plasma lycopene concentrations in the young group, whereas Cu, Se, Cu/Zn ratio, 25(OH) vitamin D, α-tocopherol, and γ-tocopherol were higher in old participants. Postprandial variability of Zn, vitamin C, and lycopene showed a strong time-dependency. Age-related differences in postprandial metabolism were observed for Se, Cu, and I. Nevertheless, most of the variance was explained by individuality. Despite some limitations, this study provides insights into postprandial micronutrient metabolism (in serum/plasma), emphasizing the need for further research for a comprehensive understanding of this complex field. Our discoveries offer valuable insights for designing targeted interventions to address and mitigate micronutrient deficiencies in older adults, fostering optimal health and well-being across the lifespan.