West Bengal

西孟加拉邦
  • 文章类型: Journal Article
    人权为追求公共卫生正义以实现所有人的尊严提供了普遍的基础。尽管国际社会试图在健康方面促进人权,相当一部分印度土著居民对这些权利的理解仍然有限。
    本研究旨在分析部落居民对卫生保健中人权的态度。人口由西孟加拉邦Puruliya区Manbazar-I和PunchaBlocks的部落居民组成,印度。年龄在18至35岁之间的部落年轻人是横断面研究的主题。
    使用预先测试的问卷收集数据。使用MSExcel和SPSS27进行分析。进行了描述性分析。
    参与者的意识平均得分,可访问性和通信,自主性和生殖健康以及性和生殖健康权利(SRHR)分别为8.06、15.76、7.35和32.52,表明选定地区的年轻成年部落人口的感知水平中等。
    需要政府和其他非政府组织对部落的整体关注。在教育课程中引入医疗保健中人权的各个方面以及社区外联,很可能会改善对“人权”的认识,从而有助于更好地利用各种服务,包括印度部落人口的健康。
    UNASSIGNED: Human rights provide a universal foundation for pursuing justice in public health in order to achieve the dignity of all individuals. In spite of international attempts to promote human rights in the context of health, a significant portion of India\'s indigenous population continues to have a limited understanding of these rights.
    UNASSIGNED: This study aims to analyze tribal people\'s attitudes towards human rights in health care. The population consists of tribal residents from Manbazar - I and Puncha Blocks in the Puruliya district of West Bengal, India. Tribal young adults between the ages of 18 and 35 were the subject of a cross-sectional study.
    UNASSIGNED: A pretested questionnaire was used to collect data. MS Excel and SPSS 27 were used for analysis. A descriptive analysis was carried out.
    UNASSIGNED: The participants\' mean scores for awareness, accessibility and communication, autonomy and sexual and reproductive health and sexual and reproductive health rights (SRHR) were 8.06, 15.76, 7.35 and 32.52 revealing a moderate perception level among the young adult tribal population in the selected blocks.
    UNASSIGNED: A holistic focus of the governmental and other non-governmental organizations towards the tribals is required. Introducing various aspects of human rights in healthcare in the education curriculum along with community outreach would by all likelihood improve the perception of \'Human Rights\' and thus help in better utilization of various services including health among tribal populations in India.
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  • 文章类型: Journal Article
    月经卫生管理与妇女的生殖健康密切相关。月经健康和卫生需求,由于许多原因,特别是部落妇女仍然没有得到满足。不适当的月经行为会导致不良的健康后果。
    这项研究旨在确定15至49岁部落已婚妇女的月经卫生行为及其相关因素。
    一项描述性横断面研究于2019年5月至2020年4月在PaschimBardhaman区的Barabani街区进行,西孟加拉邦.从研究区域的10个部落村庄中随机选择了530名妇女的计算样本;通过预先设计的社会人口统计学和月经卫生行为特征时间表对他们进行了采访。月经卫生管理评分是基于五个基本组成部分得出的-卫生吸收剂,吸收剂的卫生处理,吸收剂的变化频率,清洁外生殖器和清洁水源;月经卫生行为被归类为有利和不利。使用SPSSv.20进行双变量和多变量逻辑回归。
    所有530名妇女都是印度教徒,属于圣塔尔族;53.4%是文盲。43.8%的女性使用了卫生巾;63%的人不分青红皂白地投掷以处置吸收剂;86%的人练习适当更换吸收剂。总的来说,63%的人有良好的月经卫生管理行为,发现妇女的识字状况是一个重要的预测因素。
    不利的月经习惯在部落妇女中仍然普遍存在,主要原因是缺乏知识。提高认识应侧重于改进这些做法,这也将导致总体健康状况的改善。
    UNASSIGNED: Menstrual hygiene management is integrally associated with reproductive health of women. Menstrual health and hygiene needs, particularly of tribal women still remain unmet for many reasons. Inappropriate menstrual behaviour leads to adverse health consequences.
    UNASSIGNED: This study aimed to ascertain the menstrual hygiene behaviour of tribal married women aged 15 to 49 years and its correlates.
    UNASSIGNED: A descriptive cross-sectional study was conducted from May 2019 to April 2020 in the Barabani block of Paschim Bardhaman district, West Bengal. A calculated sample of 530 women was selected randomly from 10 tribal villages of the study area; they were interviewed through a pre-designed schedule for socio-demographic and menstrual hygiene behaviour characteristics. Menstrual hygiene management score was derived based on five essential components- hygienic absorbents, hygienic disposal of absorbents, frequency of changing of absorbents, cleaning of external genitalia and source of water for cleaning; menstrual hygiene behaviour was categorised as favourable and unfavourable. Bivariate and multivariable logistic regression was performed using SPSS v. 20.
    UNASSIGNED: All 530 women were Hindu and belonged to Santhal ethnicity; 53.4% were illiterate. Sanitary pads were used by 43.8% of women; 63% practised indiscriminate throwing for disposal of absorbents; 86% practised appropriate changing of absorbents. Overall, 63% had favourable menstrual hygiene management behaviour, and the literacy status of women was found to be a significant predictor.
    UNASSIGNED: Unfavourable menstrual practices are still widely prevalent among tribal women, mainly attributable to lack of knowledge. Awareness generation should be focused on improving those practices, which would also result in the improvement of general health conditions.
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  • 文章类型: Journal Article
    西孟加拉邦正在经历孕妇中未预料到的子痫风险,并且它仍然是孕产妇死亡的主要原因。本研究旨在调查西孟加拉邦子痫孕产妇死亡的预测因素。
    本研究采用回顾性混合方法,涵盖设施和基于社区的孕产妇死亡审查方法。317例死亡病例使用了基于设施的数据,其中40例使用了基于社区的审查方法。还对12名护理人员进行了深入访谈。
    三分之一的产妇死亡是由子痫引起的,这是西孟加拉邦孕产妇死亡的主要原因。更年轻的年龄,初生或未产状态,没有产前护理(ANC),和居住在农村地区似乎有发生子痫的最高风险。大多数孕妇有不规则的产前检查史,特别是在怀孕的中期。在距所研究医院49公里以上的妇女中,与子痫相关的孕产妇死亡率更高。大多数已故妇女在去世前被转诊到三家或更多医院。重力,非国大访问的次数,交付方式,不同程度的延迟是子痫导致死亡的显著混杂因素。没有ANC和剖宫产的妇女因子痫而死亡的风险是同组妇女的两倍。
    西孟加拉邦妇女患先兆子痫和子痫的风险很高,导致产妇死亡和发病。重力,非国大访问的次数,交付方式,和对子痫的认识延迟导致孕产妇死亡的风险。建立单独的子痫单位,加强筛查,预防和治疗程序可以优化管理子痫。
    UNASSIGNED: West Bengal is experiencing an unanticipated risk of eclampsia among pregnant women and it persists as the leading cause of maternal mortality. This study aimed to investigate the predictors for maternal deaths due to eclampsia in West Bengal.
    UNASSIGNED: The study adopted retrospective mixed methods covering facility and community-based maternal death review approaches. Facility-based data were used for 317 deceased cases wherein the community-based review approach was used in 40 cases. An in-depth interview was also performed among 12 caregivers.
    UNASSIGNED: One-third of maternal deaths occurred due to eclampsia, and this accounted for the leading cause of maternal deaths in West Bengal. A younger age, a primigravida or nulliparous status, absence of antenatal care (ANC), and residence in rural areas appeared to have the highest risk of developing eclampsia. The majority of pregnant women had an irregular antenatal check-up history, particularly during the second trimester of pregnancy. The rate of eclampsia-related maternal death was higher in women residing more than 49 km from the studied hospitals. Most of the deceased women were referred to three or more hospitals before their death. Gravidity, the number of ANC visits, the mode of delivery, and delays at different levels were significant confounders of death due to eclampsia. The risk of death due to eclampsia was two times higher among women without ANC and those who had a cesarean section than that in their counterparts.
    UNASSIGNED: Women in West Bengal have a high risk of preeclampsia and eclampsia resulting in maternal mortality and morbidity. Gravidity, the number of ANC visits, the mode of delivery, and delays in recognition of eclampsia contribute to the risk of maternal deaths. The establishment of separate eclampsia units, enhanced screening, and preventive and treatment procedures may optimize managing eclampsia.
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  • 文章类型: Journal Article
    儿童时期心理健康障碍的识别对于社会中健康的“成人角色”至关重要,因此,这项研究旨在估计“任何精神健康障碍”的严重程度,并找出其在西孟加拉邦一所医学院儿科门诊部(OPD)就诊的儿童中的相关性,并估计父母的父母压力。
    这是一项在Burdwan医学院儿科OPD中进行的描述性横断面研究,西孟加拉邦,7月至12月,2021年。通过系统随机抽样选择了288名年龄在4至12岁之间并与父母之一一起参加的儿童的计算大小。他们的一位父母(最好是母亲)接受了时间表的采访,包含预先验证的儿科症状检查表和父母压力量表。从机构道德委员会获得道德许可。数据采用SPSS-v23进行分析。
    儿童的中位年龄为7岁(5-8岁)。其中大多数是男性(57.6%),生活在城市地区(59.0%),生活在联合家庭(57.6%)。五分之一(20.5%)的儿童被发现患有任何心理健康障碍(AMHD)。生活在城市地区(aOR=2.5,95%CI:1.1-5.7),属于核心家庭(aOR=3.6,95%CI:1.7-8.1),属于有社会问题的家庭(aOR=7.8,95%CI:2.3-27.2)是AMHD的显着相关因素。与其他父母相比,AMHD儿童的父母的父母压力[中位数:60(55-63)]显着更高(P<0.001)。
    在这项研究中,AMHD的幅度很高,表明实施机会性筛查和适当公共卫生行动的必要性。
    UNASSIGNED: Identification of mental health disorders during childhood is crucial for healthy \'adult roles\' in the society, so this study aimed to estimate the magnitude of \'any mental health disorder\' and to find out its correlates among children attending the pediatric out-patient department (OPD) of a medical college in West Bengal and to estimate parental stress among their parents.
    UNASSIGNED: It was a descriptive cross-sectional study done in the pediatric OPD of Burdwan Medical College, West Bengal, during July-December, 2021. The calculated size of 288 children aged between 4 and 12 years and attending with either of their parents was selected through systematic random sampling. One of their parents (preferably mother) was interviewed using a schedule, containing a pre-validated pediatric symptom checklist and parental stress scale. Ethical clearance was obtained from the Institutional Ethics Committee. Data were analyzed using SPSS-v23.
    UNASSIGNED: The median age of the children was 7 years (5-8 y.). The majority of them were male (57.6%), lived in urban areas (59.0%), and lived in joint families (57.6%). One-fifth (20.5%) of the children were found to have any mental health disorder (AMHD). Living in an urban area (aOR = 2.5, 95% CI: 1.1-5.7), belonging to a nuclear family (aOR = 3.6, 95% CI: 1.7-8.1), and belonging to a family with social problems (aOR = 7.8, 95% CI: 2.3-27.2) were significant correlates of AMHD. Parental stress [median: 60 (55-63)] was found significantly higher (P < 0.001) among parents of children with AMHD as compared to the parents of others.
    UNASSIGNED: The magnitude of AMHD was high in this study, indicating toward the necessity of implementing opportunistic screening and appropriate public health action.
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  • 文章类型: Journal Article
    部落由于获得医疗保健的机会受到限制,是美国社会上最受排斥的群体。关于部落之间疾病的实际负担和分布的数据很少。本研究确定了西孟加拉邦部落人口中的疾病类型和模式。
    这项横断面研究使用了来自西孟加拉邦五个地区的五个街区。在2018年至2019年之间,有52,189名患者访问了这些移动医疗诊所(MMC)。但只有36,128人被纳入我们的研究.使用SPSS软件(ver。27.0).
    与其他年龄段相比,年轻年龄组(1-25岁)的主要注册率较高;年龄较大的年龄组(>60岁)的重复注册率较高。传染病患病率高(占初次登记总数的44.5%),非传染性疾病重复病例高(11.5%至33.2%),观察到这是原发性病例的近三倍(CramerV检验=0.29;P=.001)。在研究的MMC中,BinpurII和MatialiMMC患胃肠道疾病的风险是其两倍以上,而MadarihatMMC有不止一次的风险。GarbetaIIMMC显示非传染性疾病的风险(调整后比值比=3.97;95%置信区间:3.05-5.17)是其他疾病的三倍以上。
    本研究显示传染病的患病率很高,受伤和疼痛,非传染性疾病,肠胃问题,西孟加拉邦部落人口的眩晕。
    UNASSIGNED: Tribes are the most socially excluded group in the nation due to their restricted access to healthcare. There are little data on the real burden and distribution of illnesses among tribes. The present study determines the types and patterns of sickness among tribal populations in West Bengal.
    UNASSIGNED: Five blocks from five districts in West Bengal were used for this cross-sectional study. Between the years 2018 and 2019, 52,189 patients visited these mobile medical clinics (MMCs), but only 36,128 were included in our study. Data were analyzed using the SPSS software (ver. 27.0).
    UNASSIGNED: Younger age groups (1-25 years) show higher primary registration compared to other age categories; older age groups (>60 years) show higher repeat registration. High prevalence in infectious diseases (44.5% of the total primary registration) and high repeated cases in NCDs (11.5% to 33.2%), which are nearly three times higher than primary cases (Cramer\'s V test = 0.29; P = .001) are observed. Among the studied MMCs, Binpur II and Matiali MMC have more than two times the risk of gastrointestinal problems, while Madarihat MMC has more than one time the risk. Garbeta II MMC shows more than three times the risk of NCDs (adjusted odds ratio = 3.97; 95% confidence interval: 3.05-5.17) than the other diseases.
    UNASSIGNED: The present study shows high prevalence of infectious diseases, injury and pain, NCDs, gastrointestinal problems, and vertigo in tribal populations of West Bengal.
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  • 西孟加拉邦,位于印度东部,截至2016年,包括19个地区,人口91.3亿,曾是全国心理健康调查的参与州之一,2015-16。
    评估西孟加拉邦代表性人群中精神障碍的患病率和模式。
    基于多阶段分层随机整群抽样,其概率与每个阶段成正比,2646名符合条件的人接受了采访。经过训练的数据收集者根据标准化协议使用孟加拉标准验证的仪器,如社会人口统计概况和迷你国际神经精神病学访谈(MINI)版本6。
    西孟加拉邦目前的精神疾病患病率为13.07%(12.9-13.2495%CI),高于目前的全国平均水平10.56%(10.51-10.6195%CI)。严重精神疾病的患病率为2.32%,自杀风险为1.75%(1.68-1.8195%CI)高于全国平均水平。常见的精神疾病患病率为11.29(11.13-11.4595%CI),这与全国加权平均数相似。在西孟加拉邦,与全国趋势相反,严重的精神疾病更集中在农村地区。此外,酒精使用障碍的患病率为3.04(2.96-3.1395%CI),癫痫为0.03(0.27-0.2995%CI),低于全国平均水平。
    西孟加拉邦的精神障碍患病率高于全国平均水平,对于严重的精神疾病,与全国平均水平相比,患病率最高。
    UNASSIGNED: West Bengal, situated in eastern India, comprising 19 districts as of 2016 and consisting of 9.13 crore population, had been one of the participating states in the National Mental Health Survey, 2015-16.
    UNASSIGNED: To estimate the prevalence and pattern of mental disorders in a representative population in West Bengal.
    UNASSIGNED: Based upon a multi-stage stratified random cluster sampling with probability proportionate to each stage, 2646 eligible individuals were interviewed. Standard validated instruments in Bengali like socio-demographic profiles and Mini International Neuropsychiatric Interview (MINI) version 6 were used by trained data collectors with quality monitoring as per a standardized protocol.
    UNASSIGNED: The current prevalence of mental illness in the state of West Bengal is 13.07% (12.9-13.24 95% CI), which is more than the current national average of 10.56% (10.51-10.61 95% CI). The prevalence of severe mental illness of 2.32% and suicide risk of 1.75% (1.68-1.81 95% CI) is higher than the national average. The common mental illness prevalence is 11.29 (11.13-11.45 95% CI), which is similar to the national weighted average. In West Bengal, severe mental illness is more concentrated in the rural areas in contrast to the national trend. Also, the prevalence of alcohol use disorder is 3.04 (2.96-3.13 95% CI) and epilepsy is 0.03 (0.27-0.29 95% CI), which is less than the national average.
    UNASSIGNED: The prevalence of mental disorders in the state of West Bengal is higher than the national average, and for severe mental illness, the prevalence is the highest as compared to the national average.
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  • 文章类型: Journal Article
    无烟烟草,以及槟榔,导致口腔癌变和癌前病变。印度的传统价值,以及西孟加拉邦不允许女性吸烟,但是没有人反对使用无烟烟草或槟榔。地理和社会文化,西孟加拉邦的北部与南部不同。
    本研究旨在评估不同咀嚼习惯的患病率,习惯产品,西孟加拉邦两个社会文化不同地区的女性与习惯相关的不同口腔病变。
    选择了来自北孟加拉地区的222名妇女和来自南孟加拉地区的173名15岁及以上的妇女。使用结构化问卷进行了面对面访谈。进行口腔检查以排除任何由致癌习惯引起的口腔粘膜改变。
    卡方检验或Fischer\的精确检验用于酌情比较不成对比例。
    在孟加拉北部地区,42.34%的女性是咀嚼者,在孟加拉南部地区,18.50%的女性是咀嚼者。年轻的女性咀嚼者更多来自孟加拉北部地区。女人,居住在孟加拉北部的不同地区有更多的与习惯相关的口腔病变,与孟加拉南部相比。
    应特别注意提高女性对咀嚼习惯相关健康危害的认识,尤其是在北孟加拉地区。
    UNASSIGNED: Smokeless tobacco, as well as areca-nut both, causes cancerous and precancerous lesions of the oral cavity. The traditional value of India, as well as West Bengal do not allow females for smoking, but there is no such disapproval for using smokeless tobacco or areca nut. Geographically and socio-culturally, the Northern part of West Bengal differs from its Southern part.
    UNASSIGNED: This study aimed to assess the prevalence of different chewing habits, habit products, and habit-related different oral lesions among females in two socio-culturally different areas of West Bengal.
    UNASSIGNED: A total of 222 women from areas of North Bengal and 173 women from areas of South Bengal aged 15 years and above were selected. A face-to-face interview was conducted using a structured questionnaire. An oral cavity examination was done to rule out any oral mucosal alterations caused by cancer-causing habits.
    UNASSIGNED: Chi-square test or Fischer\'s exact tests were used to compare unpaired proportions as appropriate.
    UNASSIGNED: In areas of the northern part of Bengal, 42.34% of females were chewers, and in areas of the southern part of Bengal 18.50% of females were chewers. Younger female chewers were more from areas of the northern part of Bengal. Women, residing in different areas of the northern part of Bengal had more habit-related oral lesions, compared to the southern part of Bengal.
    UNASSIGNED: Special attention should be given to increasing awareness regarding chewing habit-related health hazards among females, especially in areas of North Bengal.
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  • 文章类型: Journal Article
    一种新的古细菌(半翅目:球科:Monophlebidae),PerissopneumonkalyanienseDas&Dassp.11月。,是从在五叶Glycosis的树枝上收集的标本中描述的(Retz。)DC。(芦荟科),一种来自Kalyani的药用植物,西孟加拉邦,印度。新物种类似于PerissopneuonferoxNewstead1900,但可以通过腹侧多房孔和肛门管的不同特征状态来区分。提供了在全球范围内发现的PerissopneumonNewstead物种的最新识别密钥。讨论了PerissopneumonNewstead属的现状。
    A new archaeococcoid (Hemiptera: Coccomorpha: Monophlebidae), Perissopneumon kalyaniense Das & Das sp. nov., is described from specimens collected on twigs of Glycosmis pentaphylla (Retz.) DC. (Rutaceae), a medicinal plant from Kalyani, West Bengal, India. The new species is similar to Perissopneumon ferox Newstead 1900, but can be distinguished by different character states of ventral multilocular pores and anal tube. An updated identification key to the species of Perissopneumon Newstead found worldwide is provided. The current status of the genus Perissopneumon Newstead is discussed.
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  • 文章类型: Journal Article
    医生之间的沟通模式,护士和患者决定了医疗保健服务的效率,以及医护人员的工作满意度。工作满意度对于确保保留医生和护士人群很重要。在大流行前和COVID-19时代,患者亲属和家庭成员对医生和护士的袭击事件变得很频繁。除了感谢在大流行期间服务的一线医护人员,有针对他们的身体暴力,因为他们未能挽救受感染的患者。利用布迪厄的社会空间概念,资本的形式,并习惯了本文试图对在医患中观察到的一些相互作用模式进行理论化,护士-病人,和医生-护士的遭遇,导致医护人员和更广泛的社会之间的关系减弱,如在西孟加拉邦观察到的那样,印度。主要的经验数据是通过亲自收集的,在整个2018年,加尔各答(主要大都市中心)的5家政府医院和人口为100,000的郊区的1家医院进行了开放式和封闭式问题的深入半结构化访谈。受访者包括51名护士(100%为女性),20名医生(5%为女性)33例患者(33.3%为女性)采用目的性和滚雪球取样。社会空间分析表明,累积的患者社会资本与医生相当,尽管医生的文化和经济资本水平较高,因为病人与医生的比例高。因此,患者群体可以集中并委托他们的社会资本来选择导致暴力侵害医护人员的代理人。通过这种分析,假定了两位医生的习性,还有护士和病人的习惯.第一个医生习惯是由医生的理想化状态构成的,第二个习惯是由他们资源有限的工作条件构成的。护士习惯是由对经济赋权的渴望以及尽职尽责地按照指示提供护理而构成的。患者的习惯是由平衡医疗保健支出和有限的财务手段的需要构成的。本文建立了代理人的习惯和医疗保健的政治相互作用,以加剧医护人员与他们所关心的人群之间的现有紧张关系。
    Communication patterns between doctors, nurses and patients determine both the efficiency of healthcare delivery, and the job satisfaction of healthcare workers. Job satisfaction is important to ensure retention of the doctor and nurse populations. Incidents of assault against physicians and nurses from relatives and family members of patients have become frequent both in the pre-pandemic and COVID-19 eras. Along with appreciation for frontline healthcare workers serving during the pandemic, there is physical violence directed at them for failing to salvage infected patients. Using Bourdieu\'s concepts of social space, forms of capital, and habitus this paper endeavors to theorize some of the interaction patterns observed in doctor-patient, nurse-patient, and doctor-nurse encounters that contribute to the waning of the relationship between healthcare workers and wider society as observed in West Bengal, India. Primary empirical data was collected through in-person, in-depth semi-structured interviews with both open and closed-ended questions conducted throughout 2018 across 5 government hospitals in Kolkata (major metropolitan center) and 1 hospital in a suburban area with population 100,000. The respondents consisted of 51 nurses (100% women), 20 doctors (5% women), and 33 patients (33.3% women) recruited using purposive and snowball sampling. Social space analysis indicated that the cumulative patient social capital is comparable to that of the doctors, despite the doctor\'s higher levels of cultural and economic capital because of the high patient to doctor ratio. The patient population can thus concentrate and delegate their social capital to select agents leading to violence against healthcare workers. Through this analysis, two doctors\' habitus were postulated, along with a nurse and a patient habitus. The first doctor habitus is structured by the idealized status of doctors and the second habitus is structured by their resource-limited working conditions. The nurse habitus is structured by the desire for economic empowerment along with dutifully providing care as instructed. The patient habitus is structured by the need to balance healthcare expenditures with their limited financial means. This paper establishes how the habitus of the agents and the politics of healthcare interact to exacerbate extant tensions between healthcare workers and the population they care for.
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  • 文章类型: Journal Article
    在严重急性呼吸道综合症冠状病毒2(SARS-CoV-2)的大流行中,病毒变体的进化及其对病毒传播的影响已成为相当重要的领域。我们分析了西孟加拉邦大流行不同阶段的病毒变体,印度的一个州,在地理上很重要,并将这些变体与德里等其他州进行了比较,马哈拉施特拉邦,和卡纳塔克邦,位于该国其他地区。我们已经在3,198个SARS-CoV-2基因组中确定了57个pango谱系,改变它们的分布,以及不同状态下不同波的氨基酸突变动力学对比。还研究了Delta(B.1.617.2)亚谱系的演变特征以及由这些突变引起的病毒蛋白疏水性谱的改变。此外,突出了预测性宿主miRNA与新出现的尖峰或核衣壳突变结合/解结合的含义。我们的结果为病毒基因组变异的有趣方面提供了相当大的启示,并为在大流行的展开中更好地理解波定义突变提供了有价值的信息。重要性在2019年冠状病毒病(COVID19)大流行期间,印度许多州都观察到多波感染。在四个波窗口类别中,主要SARS-CoV-2谱系和子谱系的精细演变:印度四个主要州的第1波,第1波,第2波和第2波:德里(北部),马哈拉施特拉邦(西),卡纳塔克邦(南部),使用大规模病毒基因组测序数据研究了西孟加拉邦(东部)。我们的综合分析揭示了波定义突变的对比分子谱及其在印度主要州的宿主miRNA结合/解开谱系中的意义。
    The evolution of viral variants and their impact on viral transmission have been an area of considerable importance in this pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We analyzed the viral variants in different phases of the pandemic in West Bengal, a state in India that is important geographically, and compared the variants with other states like Delhi, Maharashtra, and Karnataka, located in other regions of the country. We have identified 57 pango-lineages in 3,198 SARS-CoV-2 genomes, alteration in their distribution, as well as contrasting profiles of amino acid mutational dynamics across different waves in different states. The evolving characteristics of Delta (B.1.617.2) sublineages and alterations in hydrophobicity profiles of the viral proteins caused by these mutations were also studied. Additionally, implications of predictive host miRNA binding/unbinding to emerging spike or nucleocapsid mutations were highlighted. Our results throw considerable light on interesting aspects of the viral genomic variation and provide valuable information for improved understanding of wave-defining mutations in unfolding the pandemic. IMPORTANCE Multiple waves of infection were observed in many states in India during the coronavirus disease 2019 (COVID19) pandemic. Fine-scale evolution of major SARS-CoV-2 lineages and sublineages during four wave-window categories: Pre-Wave 1, Wave 1, Pre-Wave 2, and Wave 2 in four major states of India: Delhi (North), Maharashtra (West), Karnataka (South), and West Bengal (East) was studied using large-scale virus genome sequencing data. Our comprehensive analysis reveals contrasting molecular profiles of the wave-defining mutations and their implications in host miRNA binding/unbinding of the lineages in the major states of India.
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