钛基材料是生物医学应用中应用最广泛的材料。然而,根据文献发现,钛的降解产物与潜在的过敏反应有关,炎症,和骨吸收。Ti-6Al-4V在人体环境中的腐蚀过程可能因诸如降低的pH水平和升高的氯化物浓度等因素而加剧。由生物聚合物制成的涂层获得关注,因为它们为增强植入物功能提供了许多优势。包括改善生物相容性,生物活性,润湿性,药物释放,和抗菌活性。这项研究分析了通过静电纺丝方法进行PCL和PCL/TiO2沉积的Ti-6Al-4VELI合金的物理化学和电化学行为。为了表征基于聚合物的层,化学和相组成测试,以及表面形态调查,被执行了。进行润湿角测试作为评估物理化学性质的一部分。对样品进行腐蚀行为分析,其中包括开路电位测量,动电位试验,和电化学阻抗光谱法。此外,使用电感耦合等离子体原子发射光谱法(ICP-AES)对电位动力学测试后释放的离子进行定量。还进行了细胞毒性测试。已发现,通过使用静电纺丝方法在钛基材材料上沉积基于聚合物的层进行表面改性可提供改善的腐蚀行为,样品表现出无毒特性。
Titanium-based materials are the most widely used materials in biomedical applications. However, according to literature findings, the degradation products of titanium have been associated with potential allergic reactions, inflammation, and bone resorption. The corrosion process of Ti-6Al-4V in the human body environment may be exacerbated by factors such as reduced pH levels and elevated concentrations of chloride compounds. Coatings made of biopolymers are gaining attention as they offer numerous advantages for enhancing implant functionality, including improved biocompatibility, bioactivity, wettability, drug release, and antibacterial activity. This study analyzes the physicochemical and electrochemical behavior of the Ti-6Al-4V ELI alloy subjected to PCL and PCL/TiO2 deposition by the electrospinning method. To characterize the polymer-based layer, tests of chemical and phase composition, as well as surface morphology investigations, were performed. Wetting angle tests were conducted as part of assessing the physicochemical properties. The samples were subjected to corrosion behavior analysis, which included open circuit potential measurements, potentiodynamic tests, and the electrochemical impedance spectroscopy method. Additionally, the quantification of released ions post the potentiodynamic test was carried out using the inductively coupled plasma atomic emission spectrometry (ICP-AES) method. Cytotoxicity tests were also performed. It was found that surface modification by depositing a polymer-based layer on the titanium substrate material using the electrospinning method provides improved corrosion behavior, and the samples exhibit non-toxic properties.