PDF(Pubmed)
Abstract：
Introduction: Titanium-based implants can be used to fill voids in bone reconstruction surgery. Through additive manufacturing (AM), it is possible to produce titanium implants with osteoconductive properties such as high porosity and low stiffness. AM facilitates a level of design flexibility and personalization that is not feasible with traditional techniques. Methods: In this study, osseointegration into titanium alloy (Ti-6Al-4V) lattices was investigated for 12 weeks post-implantation using a novel bicortical load-bearing ovine model. The objective was to assess the safety and efficacy of AM-fabricated implants using two lattice structures of contrasting stiffness spanning the full width of the femoral condyle. Results: This was achieved by evaluating implant osseointegration and bone-implant contact properties by histomorphometry, scoring local implant tissue responses via histopathology, and micro-computed tomography reconstruction. Discussion: We found that Ti-6Al-4V implants facilitated widespread and extensive osseointegration, with bone maturation ongoing at the conclusion of the trial period. Following the implantation period, no adverse clinical indications that could be directly ascribed to the presence of the implanted device were identified, as determined by macroscopic and microscopic observation.
摘要：
简介：钛基植入物可用于填充骨重建手术中的空隙。通过增材制造(AM)，有可能生产具有骨传导性能如高孔隙率和低刚度的钛植入物。AM促进了传统技术不可行的设计灵活性和个性化水平。方法:在本研究中,植入后12周，使用新型双皮质承载绵羊模型研究了骨整合到钛合金（Ti-6Al-4V）晶格中。目的是使用跨越股骨髁整个宽度的对比刚度的两种晶格结构来评估AM制造的植入物的安全性和有效性。结果：这是通过组织形态计量学评估植入物骨整合和骨-植入物接触特性来实现的，通过组织病理学对局部植入物组织反应进行评分，和显微计算机断层扫描重建。讨论：我们发现Ti-6Al-4V植入物促进了广泛和广泛的骨整合，在试验期结束时，骨骼正在成熟。植入期之后,没有发现可直接归因于植入装置存在的不良临床适应症，通过宏观和微观观察确定。
