■10%的癌症患者出现皮肤转移,但是皮肤转移瘤的标准化皮肤镜诊断标准仍然很差。本研究的目的是分析晚期全身和皮肤癌皮肤转移的皮肤镜特征。
■对来自33例各种原发癌患者的715个皮肤转移瘤图像的回顾性研究(乳腺癌,子房,黑色素瘤,非黑色素瘤皮肤癌,和慢性白血病)在2013年至2023年期间参加了两个学术中心。四个独立的观察者盲目地分析了模式,颜色,船只,和每个转移的基本病变(总共30个参数)。
■无结构白色图案是皮肤转移的最突出指标(81.26%,p<0.001)。不管是什么原发肿瘤,颜色粉红色,红色,白色,并确认了Tan的身份.原发性病变很少见,除了黑色素瘤转移显示点(13.23%)和小球(11.11%)。乳腺癌转移显示:蓝色(41.48%)和红色(34.32%),不规则血管(13.58%),和蓝色痣图案(22.22%)。黑色素瘤转移显示:蓝痣模式(61.38%),蓝色(85.71%),和无结构蓝色组合模式(79.37%)。非黑色素瘤皮肤癌转移的特征是血管(42.11%)和血管瘤样(31.58%)模式,粉色(57.89%)和红色(57.89%),不规则(57.89%),薄发夹(47.37%),逗号(47,37%),和厚发夹(26,32%)的血管和红色,白色和不规则血管组合模式(52,63%)。在慢性白血病转移中,粉红色无结构组合模式很常见(61.05%)。卵巢癌转移显示白色和棕褐色无结构组合模式(100%),并且经常有点状血管(42.85%)。
■白色无结构的丘疹和结节提示皮肤转移,无论原发性肿瘤。蓝色无结构病变指示黑素瘤转移,并且具有不规则血管的血管图案指示非黑素瘤皮肤癌转移。对于已知癌症病史的患者,皮肤镜检查是一种可靠的非侵入性诊断方法。
UNASSIGNED: Skin metastases arise in 10% of cancer patients, but standardized dermoscopy diagnostic criteria for skin metastases remain poor. This study\'s objective was to analyze the dermoscopy features of skin metastases from advanced systemic and cutaneous cancers.
UNASSIGNED: A retrospective study on 715 dermoscopy images of skin metastases from 33 patients with various primary cancers (breast, ovary, melanoma, non-melanoma skin cancer, and chronic leukemia) attending two academic centers between 2013 and 2023 was performed. Four independent observers blindly analyzed patterns, colors, vessels, and elementary lesions for each metastasis (30 parameters in total).
UNASSIGNED: The structureless white pattern was the most prominent indicator of cutaneous metastasis (81.26%, p < 0.001). Regardless of the primary tumor, colors pink, red, white, and tan were identified. Elementary lesions were infrequent, except for melanoma metastases that displayed dots (13.23%) and globules (11.11%). Breast cancer metastases presented: blue (41.48%) and red (34.32%) colors, irregular vessels (13.58%), and a blue-naevus pattern (22.22%). Melanoma metastases displayed: a blue-naevus pattern (61.38%), a blue color (85.71%), and a structureless-blue combination pattern (79.37%). Non-melanoma skin cancer metastases were characterized by vascular (42.11%) and angioma-like (31.58%) patterns, pink (57.89%) and red (57.89%) colors, irregular (57.89%), thin hairpin (47.37%), comma (47, 37%), and thick hairpin (26, 32%) vessels and a red, white and irregular vessels combination pattern (52, 63%). A pink structureless combination pattern was frequent (61.05%) in chronic leukemia metastases. Ovarian cancer metastases displayed a white and tan structureless combination pattern (100%) and frequently had dotted vessels (42.85%).
UNASSIGNED: Papules and nodules with a white structureless pattern suggest skin metastases, regardless of the primary tumor. A blue structureless lesion is indicative of melanoma metastasis and a vascular pattern with irregular vessels indicates a non-melanoma skin cancer metastasis. Dermoscopy stands as a reliable non-invasive diagnostic method for suspected cutaneous metastases in patients with a known cancer history.