关键词: Cutaneous metastases Endometrial cancer Endometrial carcinoma Skin metastases

Mesh : Carcinoma, Endometrioid / secondary Endometrial Neoplasms / pathology therapy Female Humans Lymphatic Metastasis / pathology Middle Aged Postmenopause Prognosis Skin Neoplasms / pathology secondary

来  源:   DOI:10.1007/s00404-021-06165-w

Abstract:
Cutaneous metastases of endometrial carcinoma are rare. We report a case of a 54-year-old woman who developed cutaneous metastases from an endometrial carcinoma, and review the related literature to offer insight into this rare and serious condition.
The clinical and pathological data and therapy delivered to a patient from Peking University People\'s Hospital, were retrieved from her medical records. A systematic literature search regarding this unusual disease progression was conducted through PubMed/MEDLINE.
A postmenopausal patient diagnosed with stage IB endometrioid carcinoma rapidly developed cutaneous metastases. 10 months postoperatively, the patient developed multiple lymph node metastases, and 22 months later, cutaneous metastases appeared on both breasts. She was then treated with chemotherapy, immunotherapy and hormone therapy. The skin lesions eased temporarily but deteriorated quickly. Ultimately, she died in 7 months subsequent to the appearance of cutaneous lesions.
Cutaneous metastases from endometrial carcinoma have usually been incurable and associated with a limited prognosis.
摘要:
子宫内膜癌的皮肤转移很少见。我们报告了一例54岁的女性,她从子宫内膜癌中发展为皮肤转移,并回顾相关文献,以深入了解这种罕见和严重的情况。
北京大学人民医院患者的临床病理资料和治疗,是从她的医疗记录中找到的.通过PubMed/MEDLINE进行了关于这种异常疾病进展的系统文献检索。
一名诊断为IB期子宫内膜样癌的绝经后患者迅速发展为皮肤转移。术后10个月,患者出现多个淋巴结转移,22个月后,两个乳房均出现皮肤转移。然后她接受了化疗,免疫疗法和激素疗法。皮损暂时缓解,但迅速恶化。最终,她在皮肤病变出现后7个月内死亡。
子宫内膜癌的皮肤转移通常是无法治愈的,并且预后有限。
公众号