背景:近视正在成为世界公共卫生系统的巨大负担。目的探讨溴莫尼定治疗形觉剥夺性近视(FDM)的效果及眼压(IOP)与近视发展的关系。
方法:在3周龄色素性雄性豚鼠中诱导单眼形觉剥夺性近视(FDM)。他们用3种不同的溴莫尼定给药方法治疗(滴眼液,和结膜下或玻璃体内注射)。每种方法测试了四种不同浓度的溴莫尼定(2微克/微升,4µg/µL,20µg/µL,和40µg/µL)。所有治疗持续21天。眼压测定,视网膜镜检查,A-扫描超声用于监测眼压,屈光不正和轴向长度(AL),分别。
结果:结膜下溴莫尼定治疗40µg/µL,和玻璃体内溴莫尼定2µg/µL和4µg/µL,抑制FDM的发展。近视折射,轴向长度过大,眼压升高明显下降。眼药水中的溴莫尼定无效。
结论:适当剂量的溴莫尼定可显著降低豚鼠FD近视的发生。IOP可能随FD近视而改变。
BACKGROUND: Myopia is becoming a huge burden on the world\'s public health systems. The purpose of this study was to explore the effect of brimonidine in the treatment of form-deprivation myopia (FDM) and the relationship between intraocular pressure (IOP) and myopia development.
METHODS: Monocular form deprivation myopia (FDM) was induced in three-week-old pigmented male guinea pigs. They were treated with 3 different methods of brimonidine administration (eye drops, and subconjunctival or intravitreal injections). Four different concentrations of brimonidine were tested for each method (2µg/µL, 4µg/µL, 20µg/µL, and 40µg/µL). All treatments continued for a period of 21 days. Tonometry, retinoscopy, and A-scan ultrasonography were used to monitor intraocular pressure, refractive error and axial length (AL), respectively.
RESULTS: Treatment with subconjunctival brimonidine at 40µg/µL, and intravitreal brimonidine at 2µg/µL and 4µg/µL, inhibited the development of FDM. The myopic refraction, excessive axial length, and elevation of IOP were significantly decreased. Brimonidine in eye drops was ineffective.
CONCLUSIONS: Brimonidine at appropriate doses significantly reduced the development of FD myopia in guinea pigs. The IOP may change with FD myopia.