目的:本研究旨在研究使用全身正电子发射断层扫描/计算机断层扫描(PET/CT)扫描仪在减少采集时间的情况下进行呼吸门控成像的性能。
方法:分析了71例可疑恶性肿瘤患者的影像学数据,这些患者接受了全身2-[18F]-氟-2-脱氧-D-葡萄糖PET/CT15分钟的呼吸记录。每次检查,进行了4次重建:Ungated-15,使用所有的巧合;Ungated-5,使用前5分钟的数据;Gated-15,使用所有的巧合,但使用呼吸门控;Gated-6,使用前6分钟的呼吸门控数据.量化病变并评估图像质量;在四个图像集之间进行比较。
结果:在胸部和上腹部共发现390个病灶。门控15(97.2%)的病变可检测性显着高于未门控15(93.6%,p=0.001)和未门控5(92.3%,p=0.001),但与Gated-6相当(95.9%,p=0.993)。共选择131个病灶进行定量分析。Gated-15的病变呈现明显更大的标准化摄取值,肿瘤与肝脏的比率,和肿瘤与血液的比例,但代谢性肿瘤体积较小,与Ungated-15和Ungated-5中的那些相比(所有p<0.001)。这些差异在小病变和纵隔/腹膜后以外部位的病变中更为明显。然而,这些指数在Gated-15和Gated-6之间没有显着差异。Higher,但可以接受,与未门控图像相比,在门控图像中识别出图像噪声。
结论:使用全身PET/CT扫描仪减少扫描时间的呼吸门控成像优于非门控成像,可用于临床。
结论:•在PET成像中,呼吸门控可以改善病变的表现和可检测性,但需要更长的成像时间。•这项单中心研究表明,全身PET扫描仪可以减少和临床上可接受的扫描时间进行呼吸门控成像。
OBJECTIVE: This study aimed to investigate the performance of respiratory-gating imaging with reduced acquisition time using the total-body positron emission tomography/computed tomography (PET/CT) scanner.
METHODS: Imaging data of 71 patients with suspect malignancies who underwent total-body 2-[18F]-fluoro-2-deoxy-D-glucose PET/CT for 15 min with respiration recorded were analyzed. For each examination, four reconstructions were performed: Ungated-15, using all coincidences; Ungated-5, using data of the first 5 min; Gated-15 using all coincidences but with respiratory gating; and Gated-6 using data of the first 6 min with respiratory gating. Lesions were quantified and image quality was evaluated; both were compared between the four image sets.
RESULTS: A total of 390 lesions were found in the thorax and upper abdomen. Lesion detectability was significantly higher in gated-15 (97.2%) than in ungated-15 (93.6%, p = 0.001) and ungated-5 (92.3%, p = 0.001), but comparable to Gated-6 (95.9%, p = 0.993). A total of 131 lesions were selected for quantitative analyses. Lesions in Gated-15 presented significantly larger standardized uptake values, tumor-to-liver ratio, and tumor-to-blood ratio, but smaller metabolic tumor volume, compared to those in Ungated-15 and Ungated-5 (all p < 0.001). These differences were more obvious in small lesions and in lesions from sites other than mediastinum/retroperitoneum. However, these indices were not significantly different between Gated-15 and Gated-6. Higher, but acceptable, image noise was identified in gated images than in ungated images.
CONCLUSIONS: Respiratory-gating imaging with reduced scanning time using the total-body PET/CT scanner is superior to ungated imaging and can be used in the clinic.
CONCLUSIONS: • In PET imaging, respiratory gating can improve lesion presentation and detectability but requires longer imaging time. • This single-center study showed that the total-body PET scanner allows respiratory-gated imaging with reduced and clinically acceptable scanning time.