泌尿系统癌症占新癌症病例的13.1%和癌症相关死亡的7.9%。其中,肾癌,膀胱癌,前列腺癌和前列腺癌最为普遍,对人类健康和生活质量构成重大威胁。前列腺癌是男性泌尿体系最多见的恶性肿瘤。它是男性第二常见的恶性肿瘤,肺癌超过其发病率和死亡率。膀胱癌发病率最高,与性别有关,男性报告的发病率明显高于女性。泌尿系统的肿瘤发展与因素有关,比如吸烟,肥胖,高血压,饮食,职业暴露,和遗传学。治疗策略主要包括手术,放射治疗,和化疗。胆固醇代谢是与泌尿系统肿瘤发展和进展相关的关键生理过程。高胆固醇水平与肿瘤的发生密切相关,入侵,和转移。这需要彻底研究胆固醇代谢在泌尿系统肿瘤中的作用,并确定预防的新治疗方法,早期诊断,针对性治疗,和泌尿系统肿瘤的耐药性。
Cancers of the urinary system account for 13.1% of new cancer cases and 7.9% of cancer-related deaths. Of them, renal cancer, bladder cancer, and prostate cancer are most prevalent and pose a substantial threat to human health and the quality of life. Prostate cancer is the most common malignant tumor in the male urinary system. It is the second most common type of malignant tumor in men, with lung cancer surpassing its incidence and mortality. Bladder cancer has one of the highest incidences and is sex-related, with men reporting a significantly higher incidence than women. Tumor development in the urinary system is associated with factors, such as smoking, obesity, high blood pressure, diet, occupational exposure, and genetics. The treatment strategies primarily involve surgery, radiation therapy, and chemotherapy. Cholesterol metabolism is a crucial physiological process associated with developing and progressing urinary system tumors. High cholesterol levels are closely associated with tumor occurrence, invasion, and metastasis. This warrants thoroughly investigating the role of cholesterol metabolism in urinary system tumors and identifying novel treatment methods for the prevention, early diagnosis, targeted treatment, and drug resistance of urinary system tumors.