PDF(Pubmed)
Abstract：
UNASSIGNED: Understanding sex-specific factors contributing to advanced-stage diagnosis can guide interventions to reduce sex inequality in patients with urological cancers.
UNASSIGNED: We used linked primary care and cancer registry data to examine associations between symptoms and advanced-stage in 1151 bladder cancer and 440 renal cancer patients diagnosed between January 2012 and December 2015 in England. We performed logistic regression, adjusting for sex, age, deprivation and routes to diagnosis, including interaction terms between symptoms and sex and symptoms and age.
UNASSIGNED: Female sex (OR vs. men 1.89 [1.28-2.79]; p = 0.001) and patients presenting with urinary tract infections (OR 2.22 [1.34-3.69]) and abdominal symptoms (OR 2.19 [1.30-3.70]) were associated with increased odds of advanced-stage bladder cancer (vs. haematuria, p = 0.016 for both). Women with haematuria and men with abdominal symptoms (compared with the opposite sex with the same presenting symptom) were more likely to have advanced-stage bladder cancer. Neither sex nor symptom associations were observed for renal cancer.
UNASSIGNED: Non-haematuria symptoms are associated with higher risk of advanced-stage bladder cancer. Greater risk of advanced-stage bladder cancer in women may reflect biological differences in haematuria onset and sex differences during diagnostic process. Identifying higher risk women with haematuria may reduce sex inequalities in bladder cancer outcomes.
UNASSIGNED: We used linked primary care and cancer registry data to examine associations between symptoms and advanced-stage in 1151 bladder cancer and 440 renal cancer patients diagnosed between January 2012 and December 2015 in England. We performed logistic regression, adjusting for sex, age, deprivation and routes to diagnosis, including interaction terms between symptoms and sex and symptoms and age.
UNASSIGNED: Female sex (OR vs. men 1.89 [1.28-2.79]; p = 0.001) and patients presenting with urinary tract infections (OR 2.22 [1.34-3.69]) and abdominal symptoms (OR 2.19 [1.30-3.70]) were associated with increased odds of advanced-stage bladder cancer (vs. haematuria, p = 0.016 for both). Women with haematuria and men with abdominal symptoms (compared with the opposite sex with the same presenting symptom) were more likely to have advanced-stage bladder cancer. Neither sex nor symptom associations were observed for renal cancer.
UNASSIGNED: Non-haematuria symptoms are associated with higher risk of advanced-stage bladder cancer. Greater risk of advanced-stage bladder cancer in women may reflect biological differences in haematuria onset and sex differences during diagnostic process. Identifying higher risk women with haematuria may reduce sex inequalities in bladder cancer outcomes.
摘要：
■了解导致晚期诊断的性别特异性因素可以指导干预措施，以减少泌尿系癌症患者的性别不平等。
■我们使用关联的初级保健和癌症登记数据来检查2012年1月至2015年12月在英格兰诊断的1151名膀胱癌和440名肾癌患者的症状和晚期之间的关联。我们进行了逻辑回归，适应性，年龄,剥夺和诊断途径，包括症状和性别以及症状和年龄之间的相互作用术语。
■女性（ORvs.男性1.89[1.28-2.79]；p=0.001）和出现尿路感染（OR2.22[1.34-3.69]）和腹部症状（OR2.19[1.30-3.70]）的患者与晚期膀胱癌的几率增加有关（与血尿,两者的p=0.016)。有血尿的女性和有腹部症状的男性（与具有相同症状的异性相比）更有可能患有晚期膀胱癌。肾癌未观察到性别或症状关联。
■非血尿症状与晚期膀胱癌的高风险相关。女性晚期膀胱癌的更大风险可能反映了诊断过程中血尿发作和性别差异的生物学差异。确定血尿风险较高的女性可能会减少膀胱癌预后中的性别不平等。
■我们使用关联的初级保健和癌症登记数据来检查2012年1月至2015年12月在英格兰诊断的1151名膀胱癌和440名肾癌患者的症状和晚期之间的关联。我们进行了逻辑回归，适应性，年龄,剥夺和诊断途径，包括症状和性别以及症状和年龄之间的相互作用术语。
■女性（ORvs.男性1.89[1.28-2.79]；p=0.001）和出现尿路感染（OR2.22[1.34-3.69]）和腹部症状（OR2.19[1.30-3.70]）的患者与晚期膀胱癌的几率增加有关（与血尿,两者的p=0.016)。有血尿的女性和有腹部症状的男性（与具有相同症状的异性相比）更有可能患有晚期膀胱癌。肾癌未观察到性别或症状关联。
■非血尿症状与晚期膀胱癌的高风险相关。女性晚期膀胱癌的更大风险可能反映了诊断过程中血尿发作和性别差异的生物学差异。确定血尿风险较高的女性可能会减少膀胱癌预后中的性别不平等。
