■移动设备是电磁场(EMF)的来源,引起科学家对人类健康的日益关注,尤其是长期使用手机。关于这个问题,潜在的不利健康影响,特别是在脑功能上引起了公众的关注。有大量证据表明,天然化合物由于其抗氧化和抗炎特性而具有神经保护作用。越来越多的证据表明,藏红花素作为一种天然的生物活性化合物可以被认为是针对各种神经系统疾病的潜在治疗剂。因此,本研究调查了crocin暴露于EMF后对小脑的影响。
■将24只雄性Balb/c小鼠分为对照组,EMF组(2100MHZ),EMF+藏红花素组(2100MHZ+50mg/kg),和藏红花素组(50mg/kg)。EMF和EMF+藏红花素组中的动物连续暴露于EMF120分钟/天30天。30天后,通过组织形态学和免疫组织化学方法评估小脑皮质。
■结果表明,暴露于EMF30天对浦肯野细胞大小没有显着影响。然而,与对照组相比,EMF显着降低了星形胶质细胞的直径,并增加了胶质纤维酸性蛋白(GFAP)的表达(p<0.05)。我们的发现还表明crocin治疗可以改善星形胶质细胞的直径并使GFAP表达正常化(p<0.05)。
■这项研究得出的结论是,2100-MHzEMF通过星形胶质细胞损伤对小脑造成不利影响,而藏红花素可以部分逆转EMF相关的不利影响。
UNASSIGNED: Mobile devices are sources of electromagnetic fields (EMFs) that cause increasing concern among scientists about human health, especially with the long-term use of mobile phones. With regard to this issue, the potential adverse health effects, particularly on brain function have raised public concern. There is considerable evidence that natural compounds have neuro-protective effects due to their antioxidant and anti-inflammatory properties. Growing evidence suggests that crocin as a natural bioactive compound can be considered a potential therapeutic agent against various neurologic disorders. Therefore, the present study investigated the effects of crocin on the cerebellum after exposure to EMF.
UNASSIGNED: Twenty-four Male Balb/c mice were divided into control group, EMF group (2100 MHZ), EMF +Crocin group (2100 MHZ+50 mg/kg), and crocin group (50 mg/kg). The animals in the EMF and EMF+Crocin groups were exposed continuously for 30 days to an EMF 120 min/day. After 30 days, cerebellar cortex was evaluated by histomorphometric and immunohistochemical methods.
UNASSIGNED: The results showed that 30 days of exposure to EMF had no significant effect on Purkinje cell size. However, EMF reduced significantly the diameter of astrocytes and increased Glial fibrillary acidic protein (GFAP) expression compared to the controls (p<0.05). Our findings also indicated that crocin treatment could improve the diameter of astrocytes and normalize GFAP expression (p<0.05).
UNASSIGNED: This study concluded that 2100-MHz EMF caused adverse effects on the cerebellum through astrocyte damage and crocin could partially reverse the EMF-related adverse effects.