PCOS是一种常见的妇科疾病,最近的研究发现,与普通人群相比,PCOS更容易出现抑郁和焦虑。医院焦虑和抑郁量表(HADS)是一种流行且简单的自我管理仪器,可可靠地检测焦虑和抑郁状态。使用这个简单的筛选工具,这可能会导致对此类精神障碍的识别,这些精神障碍可能需要及时的精神病转诊。
■该研究旨在使用HADS-P问卷确定PCOS患者中焦虑和抑郁的患病率,并确定抑郁和焦虑与疾病特征之间的关联。
■在菲律宾总医院进行了方便采样,以招募18岁以上的PCOS患者。横断面设计用于抑郁和焦虑的患病率,而嵌套病例对照设计用于评估抑郁和焦虑的预测因子。HADS-P,带有独立的焦虑和抑郁分量表的自我管理评定量表,在获得同意后对参与者进行了管理。使用抑郁和焦虑子量表中任一者的>8分的截止分数来确定它们各自的患病率。使用Logistic回归分析确定临床变量与焦虑或抑郁的关联。
■共招募了253名PCOS患者。根据每个类别>8.0的HADS-P评分,提示焦虑的PCOS患者的患病率为46.25%(n:117,95%CI:39.98-52.60%),而9.09%(n:23,95%CI:5.85-13.33%)的患者提示患有抑郁症。粗逻辑回归确定存在抑郁症,不孕症,糖耐量受损,和突出的痤疮作为焦虑的预测因子;而低均等,多毛症,焦虑的存在是抑郁的预测因素。调整后的逻辑回归确定只有抑郁和不孕症的存在是焦虑的显著预测因素(n:116,LRχ2(5):15.46,p<0.01);而焦虑的存在使抑郁的几率增加2-13倍,无统计学意义(n:116,LRχ2(5):9.79,p:0.08)。
■在PCOS患者中焦虑和抑郁的患病率较高。被认为与焦虑的发展显着相关的因素是抑郁症的存在,糖耐量受损,不孕症和突出的痤疮,而抑郁症的发展是焦虑的存在,多毛症,低平价。筛查焦虑和抑郁至关重要,医生应警惕可能的精神干预的需要。
UNASSIGNED: PCOS is a common gynecologic disorder and recent studies have found that they are more prone in developing depression and anxiety compared to the general population. The Hospital Anxiety and Depression Scale (HADS) is a popular and simple self-administered instrument reliable for detecting states of anxiety and depression. Using this simple screening tool, it may lead to the identification of such mental disorders that may warrant timely psychiatric referral.
UNASSIGNED: The study aims to determine the prevalence of anxiety and depression among PCOS patients using the HADS-P questionnaire and to determine the association between depression and anxiety and disease characteristics.
UNASSIGNED: Convenience sampling was done to recruit PCOS patients >18 years old in Philippine General Hospital. Cross-sectional design was used for the prevalence of depression and anxiety, while nested case control design for the evaluation of the predictors of depression and anxiety. The HADS-P, a self-administered rating scale with independent subscales for anxiety and depression, was administered to the participants after securing consent. A cut-off score of >8 points on either of the depression and anxiety subscale was used to determine their respective prevalence. Logistic regression analysis was used to determine the association of clinical variables with anxiety or depression.
UNASSIGNED: A total of 253 patients with PCOS were recruited. On the basis of a HADS-P score of >8.0 per category, the prevalence of PCOS patients who were suggestive to have anxiety was 46.25% (n: 117, 95% CI: 39.98-52.60%), while 9.09% (n: 23, 95% CI: 5.85-13.33%) of them were suggestive to have depression. Crude logistic regression identified presence of depression, infertility, impaired glucose tolerance, and prominent acne as predictors of anxiety; whereas low parity, hirsutism, and presence of anxiety were predictors of depression. Adjusted logistic regression identified only presence of depression and infertility were significant predictors of anxiety (n: 116, LR χ2 (5): 15.46, p<0.01); while presence of anxiety increased the odds of depression by 2- to 13-fold, it was not statistically significant (n: 116, LR χ2 (5): 9.79, p: 0.08).
UNASSIGNED: There is a high prevalence of anxiety and depression among PCOS patients. The factors that were seen to be significantly associated with the development of anxiety were the presence of depression, impaired glucose tolerance, infertility and prominent acne, while for the development of depression were the presence of anxiety, hirsutism, and low parity. Screening for anxiety and depression is of paramount importance and physicians should be vigilant for the need of possible psychiatric intervention.