诊断时淋巴瘤发病率按类型和年龄的全球变化,区域,性别,和人类发展指数(HDI)类别尚未报告,可能会揭示潜在的生物学机制,并确定有针对性的干预措施的领域。
使用1988年至2012年五大洲的癌症发病率数据,我们确定了霍奇金(HL),非霍奇金(NHL),和伯基特淋巴瘤(BL)诊断为0-19岁儿童。我们估计了按地理区域划分的发病率(IRs;病例/百万)和平均年发病率变化百分比(AAPC;95%CI),性别,和HDI为每个年龄组(0-9岁和10-19岁)。
有42,440NHL,38,683HL,包括7703。2008-2012年,南欧(SE)10-19岁(yo)的NHLIR最高(19.6例/百万)。在欧洲地区和大洋洲(OC),0-9yo的HLIRs为<6例/百万,10-19yo的HLIRs为>25例/百万。BLIRs通常<5例/百万。北欧(NE),SE,在所有淋巴瘤中,OC10-19yo的APPCs发病率均显著增加,BL中增幅最大(NEAAPC:7.69%;95%CI:5.27,10.16;SEAAPC:5.21%;95%CI:3.26,7.19;OCAAPC:3.97%;95%CI:3.26,4.70).在所有年龄段的男性中,BL发病率增加了约2%。在HDI非常高的国家中,NHL和BL的发病率在10-19yo之间显着增加了约3%。
从1988年到2012年,南欧和北欧以及大洋洲的所有淋巴瘤发病率均增加。全球15个地区中有8个地区的BL发病率显著增加,男性,以及研究期间人类发展指数较高的国家。这些增加的潜在机制仍有待阐明。
Global variation in lymphoma incidence by type and age at diagnosis, region, sex, and Human Development Index (HDI) categories has not been reported, may shed light on potential biologic mechanisms and identify areas for targeted interventions.
Using the Cancer Incidence in Five Continents data from 1988 to 2012, we identified Hodgkin (HL), non-Hodgkin (NHL), and Burkitt lymphoma (BL) diagnosed in children aged 0-19 years. We estimated incidence rates (IRs; cases/million) and average annual percent change in incidence (AAPC; 95 % CI) by geographic region, sex, and HDI for each age group (0-9years and 10-19 years).
There were 42,440 NHL, 38,683 H L, and 7703 included. Southern European (SE) 10-19-year-olds (yo) had the highest IR of NHL (19.6 cases/million) in 2008-2012. HL IRs for 0-9yo were <6 cases/million and >25 cases/million for 10-19yo in European regions and Oceania (OC). BL IRs were generally <5cases/million. Northern Europe (NE), SE, and OC 10-19yo had significantly increased APPCs in incidence for all lymphomas with the largest increases in BL (NE AAPC: 7.69 %; 95 % CI: 5.27, 10.16; SE AAPC: 5.21 %; 95 % CI: 3.26, 7.19; OC AAPC: 3.97 %; 95 % CI: 3.26, 4.70). BL incidence increased among males of all ages by approximately 2 %. NHL and BL incidence increased significantly among 10-19yo in very high HDI countries by approximately 3 %.
Southern and Northern Europe and Oceania displayed increased incidence of all lymphomas studied from 1988 to 2012. BL incidence significantly increased in 8 of 15 global regions, males, and higher HDI countries over the study period. Mechanisms underlying these increases remain to be elucidated.