METHODS: 66 pediatric patients with lymphoma (47Hodgkin\'s and 19non-Hodgkin\'s lymphoma) were referred for initial staging by18F-FDG PET/CT study. All patients underwent bilateral iliac BMB and 18F-FDG PET/CT scan with no more than 2 weeks interval in-between. Follow-up for at least 6 months was used as a reference standard to compare diagnostic performance between two modalities in detecting bone marrow infiltration (BMI).
RESULTS: Sensitivity, specificity, accuracy, as well as positive and negative predictive values of 18F-FDG PET/CT in detecting BMI were (80%, 86%, 85%, 63%, and 94%) in contrast to BMB (80%, 53%, 59%, 33%, and 90%) respectively. 18F-FDG PET/CT was concordant to BMB in 39/66 patients (59%).
CONCLUSIONS: 18F-FDG PET/CT was more accurate and specific, with higher predictive values than BMB in detecting BMI during initial staging of pediatric lymphoma. In most pediatric lymphoma patients, 18F-FDG PET/CT can be used instead of BMB to determine BMI during their initial staging process.
方法:66例小儿淋巴瘤患者(47例霍奇金淋巴瘤和19例非霍奇金淋巴瘤)通过18F-FDGPET/CT研究进行初始分期。所有患者均接受双侧BMB和18F-FDGPET/CT扫描,间隔不超过2周。至少6个月的随访被用作参考标准,以比较两种模式在检测骨髓浸润(BMI)方面的诊断性能。
结果:灵敏度,特异性,准确度,以及18F-FDGPET/CT检测BMI的阳性和阴性预测值(80%,86%,85%,63%,和94%)与BMB(80%,53%,59%,33%,和90%)。在39/66例患者中,18F-FDGPET/CT与BMB一致(59%)。
结论:18F-FDGPET/CT更准确、更特异,在儿童淋巴瘤初始分期期间检测BMI的预测值高于BMB。在大多数小儿淋巴瘤患者中,在初始分期过程中,可以使用18F-FDGPET/CT代替BMB来确定BMI。