■这项研究旨在检查病理性近视(PM)眼中单个黄斑视网膜层厚度的变化,并比较PM组和对照组之间每个视网膜层的厚度,以了解视网膜灌注。
■该研究包括PM组的51只眼和对照组的51只眼。光学相干断层扫描(OCT)用于测量中央凹的每个视网膜层的厚度,侧腹,和中央凹区域。光学相干断层扫描血管造影(OCT-A)用于评估视网膜毛细血管密度。
■在PM组中,视网膜神经纤维层(RNFL),神经节细胞层(GCL),内丛状层(IPL),和内核层(INL)比对照组厚(分别为p=0.004,p=0.027,p=0.020和p<0.001),而外核层(ONL)和感光层(PRL)较薄(分别为p=0.001和p=0.003)。在其他地区,近视组的RNFL较厚,而GCL,IPL,INL,ONL更薄。OCT-A在桡骨毛细血管丛密度方面未显示两组间有显著差异(p=0.381);PM组其他丛的密度较低。
■结果显示PM中视网膜层厚度和毛细血管丛密度的变化。因此,评估单个视网膜层的厚度可以作为影响视网膜和脉络膜循环的血管疾病的指标。
UNASSIGNED: This study aimed to examine changes in the thickness of individual macular retinal layers in eyes with pathological myopia (PM) and to compare the thickness of each retinal layer between the PM and control groups to gain insights into retinal perfusion.
UNASSIGNED: The study included 51 eyes in the PM group and 51 eyes in the control group. Optical coherence tomography (OCT) was used to measure the thickness of each retinal layer in the central fovea, parafoveal, and perifoveal regions. Optical coherence tomography angiography (OCT-A) was used to evaluate the retinal capillary density.
UNASSIGNED: In the PM group, the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and inner nuclear layer (INL) were thicker than in the control group (p = 0.004, p = 0.027, p = 0.020, and p < 0.001, respectively), whereas the outer nuclear layer (ONL) and photoreceptor layer (PRL) were thinner (p = 0.001 and p = 0.003, respectively). In other regions, the RNFL was thicker in the myopic group, whereas the GCL, IPL, INL, and ONL were thinner. OCT-A did not reveal any significant difference between the groups in terms of radial capillary plexus density (p = 0.381); however, the densities of the other plexuses were lower in the PM group.
UNASSIGNED: The results showed alterations in the thickness of retinal layers and capillary plexus density in PM. Thus, assessment of the thickness of individual retinal layers may serve as an indicator of vascular diseases that affect the circulation of the retina and choroid.