PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this study was to suggest a novel approach to assessing the activity of macular neovascularization (MNV) in pathological myopia (PM) by comparing optical coherence tomography (OCT) with OCT-angiography (OCT-A).
UNASSIGNED: The Zeiss Cirrus HD-5000 was used to obtain OCT and OCT-A images of PM-MNV. The objective was to examine the characteristics of PM-MNV lesions and investigate the relationship between PM-MNV activity and changes in retinal structure in 54 patients (54 eyes). To analyze the OCT parameters associated with PM-MNV activity and their clinical significance in terms of sensitivity and specificity, we used OCT-A as a reference.
UNASSIGNED: This study included 72 patients (72 eyes), of whom 54 had good image quality and were considered for analysis. The study evaluated various OCT characteristics of MNV lesions, including the elevation of an external limiting membrane (ELM), ellipsoidal zone (EZ), retinal pigment epithelium (RPE) elevation, and EZ/RPE interruption, to identify possible parameters associated with PM-MNV activity. The interobserver consistency was found to be almost perfect. In the evaluation of PM-MNV activity, the sensitivity of ELM elevation, EZ interruption, and RPE interruption was found to be 66.7% (low), 88.4% (high), and 95.6% (high), respectively. However, the specificity was found to be 71.4% (moderate), 71.4% (moderate), and 25.4% (poor), respectively. This indicates that the current evaluation methods are not accurately assessing PM-MNV activity. We developed a new comprehensive method that used EZ interruption as the primary parameter and ELM elevation and RPE interruption as secondary parameters to evaluate PM-MNV activity with a sensitivity of 97.8% and a specificity of 85.4%.
UNASSIGNED: In PM-MNV, a novel comprehensive diagnostic method combining EZ interruption, ELM elevation, and RPE interruption might be a valuable indicator to evaluate PM-MNV activity.
UNASSIGNED: The Zeiss Cirrus HD-5000 was used to obtain OCT and OCT-A images of PM-MNV. The objective was to examine the characteristics of PM-MNV lesions and investigate the relationship between PM-MNV activity and changes in retinal structure in 54 patients (54 eyes). To analyze the OCT parameters associated with PM-MNV activity and their clinical significance in terms of sensitivity and specificity, we used OCT-A as a reference.
UNASSIGNED: This study included 72 patients (72 eyes), of whom 54 had good image quality and were considered for analysis. The study evaluated various OCT characteristics of MNV lesions, including the elevation of an external limiting membrane (ELM), ellipsoidal zone (EZ), retinal pigment epithelium (RPE) elevation, and EZ/RPE interruption, to identify possible parameters associated with PM-MNV activity. The interobserver consistency was found to be almost perfect. In the evaluation of PM-MNV activity, the sensitivity of ELM elevation, EZ interruption, and RPE interruption was found to be 66.7% (low), 88.4% (high), and 95.6% (high), respectively. However, the specificity was found to be 71.4% (moderate), 71.4% (moderate), and 25.4% (poor), respectively. This indicates that the current evaluation methods are not accurately assessing PM-MNV activity. We developed a new comprehensive method that used EZ interruption as the primary parameter and ELM elevation and RPE interruption as secondary parameters to evaluate PM-MNV activity with a sensitivity of 97.8% and a specificity of 85.4%.
UNASSIGNED: In PM-MNV, a novel comprehensive diagnostic method combining EZ interruption, ELM elevation, and RPE interruption might be a valuable indicator to evaluate PM-MNV activity.
摘要：
本研究的目的是通过比较光学相干断层扫描（OCT）与OCT血管造影（OCT-A），提出一种评估病理性近视（PM）黄斑新生血管（MNV）活性的新方法。
■ZeissCirrusHD-5000用于获得PM-MNV的OCT和OCT-A图像。目的是检查54例（54眼）PM-MNV病变的特征，并探讨PM-MNV活性与视网膜结构变化之间的关系。分析与PM-MNV活性相关的OCT参数及其在敏感性和特异性方面的临床意义。我们使用OCT-A作为参考。
■这项研究包括72名患者（72只眼），其中54名具有良好的图像质量，并考虑进行分析。该研究评估了MNV病变的各种OCT特征，包括外部限制膜（ELM）的高度，椭球区(EZ),视网膜色素上皮（RPE）升高，和EZ/RPE中断，确定与PM-MNV活动相关的可能参数。观察者之间的一致性几乎是完美的。在PM-MNV活性的评估中，ELM升高的灵敏度，EZ中断,发现RPE中断为66.7%(低)，88.4%（高），和95.6％（高），分别。然而,特异性为71.4%(中等)，71.4%(中等)，和25.4%(差)，分别。这表明当前的评估方法不能准确地评估PM-MNV活性。我们开发了一种新的综合方法，该方法以EZ中断为主要参数，以ELM升高和RPE中断为次要参数来评估PM-MNV活性，其灵敏度为97.8％，特异性为85.4％。
■在PM-MNV中，一种结合EZ中断的新型综合诊断方法，ELM高程,RPE中断可能是评估PM-MNV活性的有价值的指标。
■ZeissCirrusHD-5000用于获得PM-MNV的OCT和OCT-A图像。目的是检查54例（54眼）PM-MNV病变的特征，并探讨PM-MNV活性与视网膜结构变化之间的关系。分析与PM-MNV活性相关的OCT参数及其在敏感性和特异性方面的临床意义。我们使用OCT-A作为参考。
■这项研究包括72名患者（72只眼），其中54名具有良好的图像质量，并考虑进行分析。该研究评估了MNV病变的各种OCT特征，包括外部限制膜（ELM）的高度，椭球区(EZ),视网膜色素上皮（RPE）升高，和EZ/RPE中断，确定与PM-MNV活动相关的可能参数。观察者之间的一致性几乎是完美的。在PM-MNV活性的评估中，ELM升高的灵敏度，EZ中断,发现RPE中断为66.7%(低)，88.4%（高），和95.6％（高），分别。然而,特异性为71.4%(中等)，71.4%(中等)，和25.4%(差)，分别。这表明当前的评估方法不能准确地评估PM-MNV活性。我们开发了一种新的综合方法，该方法以EZ中断为主要参数，以ELM升高和RPE中断为次要参数来评估PM-MNV活性，其灵敏度为97.8％，特异性为85.4％。
■在PM-MNV中，一种结合EZ中断的新型综合诊断方法，ELM高程,RPE中断可能是评估PM-MNV活性的有价值的指标。
