未经证实:肾细胞癌(RCC)是源自肾上皮的常见癌症。RCC最罕见的病例之一是肉瘤样RCC(sRCC)。动物中sRCC的发生没有明确证实。
UNASSIGNED:本研究旨在观察东爪哇动物sRCC的临床病理特征,印度尼西亚,从2017年到2022年。
UNASSIGNED:本研究使用了2017年至2022年在我们实验室经组织病理学诊断为sRCC的患者。关于动物临床特征的数据,血液学,血清学,组织病理学,和免疫组织化学(IHC)进行检索和制表。分别使用简单的描述性方法和社会科学26版的统计软件包对数据进行了定性和定量分析。
未经证实:在本研究中发现了14例动物sRCC。它是在啮齿动物身上发现的,狗,和猫。sRCC主要发生在啮齿动物中(57.14%),没有特定的临床体征。sRCC的常见组织病理学发现是肾上皮细胞转变为细长的非典型梭形细胞。此外,肾上皮细胞的其他组织病理学模式,如透明细胞,肾小管囊性,还发现了乳头状。通过使用抗体的IHC证明PAX8在sRCC组织样品92.85%(13/14样品)上表达。因此,PAX8可以作为建立动物sRCC诊断的支持方法。血液学和血清学测试与纯sRCC或去分化sRCC的类型无关。sRCC导致啮齿动物和狗的高肌酐血症。
UNASSIGNED:这项研究表明,动物中sRCC的发生率很少。具有sRCC的动物没有显示任何特定的临床体征。组织病理学发现很难与其他RCC区分开。肾组织样品上的PAX8表达可用于支持动物中sRCC的诊断。
Renal cell carcinoma (RCC) is common cancer derived from the renal epithelium. One of the rarest cases of RCC is sarcomatoid RCC (sRCC). The occurrence of sRCC in animals is not clearly demonstrated.
This study aimed to observe the clinicopathological characteristics of sRCC in animals from East Java, Indonesia, from 2017 to 2022.
This study used patients who were histopathologically diagnosed with sRCC in our laboratory from 2017 to 2022. The data on the clinical characteristics of animals, hematology, serology, histopathology, and immunohistochemistry (IHC) were retrieved and tabulated. The data were qualitatively and quantitatively analyzed using a simple descriptive method and Statistical Package for the Social Sciences version 26, respectively.
Fourteen cases of sRCC in animals have been identified in this study. It was found in rodents, dogs, and cats. sRCC predominantly occurred in rodents (57.14%) without specific clinical signs. The common histopathological findings of sRCC were epithelial renal cells transition into elongated atypical spindle cells. In addition, other histopathological patterns of a renal epithelial cell such as clear cell, tubule-cystic, and papillary also have been found. IHC by using antibodies demonstrates that
PAX8 is expressed on sRCC tissue samples 92.85% (13/14 samples). Hence,
PAX8 could be used as a supporting method for establishing the diagnosis of sRCC in animals. Hematology and serological tests did not correlate to the type of sRCC either pure sRCC or dedifferentiated sRCC. sRCC results in hypercreatinemia in rodents and dogs.
This study shows that the incidence of sRCC in animals is rare. Animals with sRCC did not show any specific clinical signs. The histopathological finding is quite difficult to be differentiated from the other RCC.
PAX8 expression on renal tissue samples is useful in supporting the diagnosis of sRCC in animals.