PDF(Pubmed)
Abstract：
UNASSIGNED: Small cell lung cancer (SCLC) shows poor prognosis since it metastasizes widely at early stage. Paired box gene (PAX) 8 is a transcriptional factor of PAX family, of which the expression in lung cancer is a controversial issue, and its prognostic value of PAX8 in SCLC is still unclear.
UNASSIGNED: Overall, 184 subjects who were pathologically diagnosed with SCLC were enrolled in the study. Immunohistochemical analysis of PAX8 and Ki-67 were performed. The correlations between PAX8 expression and clinical features or Ki-67 index were further analyzed. Subsequently, an analysis of the association between PAX8, stage, Ki-67 status, and overall survival (OS) were performed in 169 subjects with follow-up information.
UNASSIGNED: PAX8 was positive in 53.8% (99/184) SCLC specimens. The positive rate is significantly higher in extensive-stage specimens (61.0%) than in limited-stage specimens (45.24%). PAX8 expression is positively correlated with Ki-67 index (P = 0.001) while negatively correlated with OS (HR = 3.725, 95% CI 1.943-7.139, P＜0.001). In combination groups, the PAX8 negative and limited stage group had the most promising OS.
UNASSIGNED: PAX8 expression rate in SCLC specimens is not low. It has prognostic value in small cell lung cancer.
UNASSIGNED: Overall, 184 subjects who were pathologically diagnosed with SCLC were enrolled in the study. Immunohistochemical analysis of PAX8 and Ki-67 were performed. The correlations between PAX8 expression and clinical features or Ki-67 index were further analyzed. Subsequently, an analysis of the association between PAX8, stage, Ki-67 status, and overall survival (OS) were performed in 169 subjects with follow-up information.
UNASSIGNED: PAX8 was positive in 53.8% (99/184) SCLC specimens. The positive rate is significantly higher in extensive-stage specimens (61.0%) than in limited-stage specimens (45.24%). PAX8 expression is positively correlated with Ki-67 index (P = 0.001) while negatively correlated with OS (HR = 3.725, 95% CI 1.943-7.139, P＜0.001). In combination groups, the PAX8 negative and limited stage group had the most promising OS.
UNASSIGNED: PAX8 expression rate in SCLC specimens is not low. It has prognostic value in small cell lung cancer.
摘要：
■小细胞肺癌（SCLC）在早期广泛转移，因此预后较差。配对盒基因(PAX)8是PAX家族的转录因子,其中在肺癌中的表达是一个有争议的问题，PAX8在SCLC中的预后价值尚不清楚。
■总的来说，184名病理诊断为SCLC的受试者被纳入研究。对PAX8和Ki-67进行免疫组织化学分析。进一步分析PAX8表达与临床特征或Ki-67指数的相关性。随后，分析PAX8，阶段，Ki-67状态，和总生存期（OS）的169名受试者进行了随访信息。
■PAX8在53.8%(99/184)SCLC样本中是阳性的。广泛阶段标本的阳性率（61.0％）明显高于有限阶段标本（45.24％）。PAX8表达与Ki-67指数呈正相关(P=0.001),与OS呈负相关(HR=3.725,95%CI1.943~7.139,P＜0.001).在组合组中，PAX8阴性和有限阶段组的OS最有希望.
■PAX8在SCLC标本中的表达率并不低。它在小细胞肺癌中具有预后价值。
■总的来说，184名病理诊断为SCLC的受试者被纳入研究。对PAX8和Ki-67进行免疫组织化学分析。进一步分析PAX8表达与临床特征或Ki-67指数的相关性。随后，分析PAX8，阶段，Ki-67状态，和总生存期（OS）的169名受试者进行了随访信息。
■PAX8在53.8%(99/184)SCLC样本中是阳性的。广泛阶段标本的阳性率（61.0％）明显高于有限阶段标本（45.24％）。PAX8表达与Ki-67指数呈正相关(P=0.001),与OS呈负相关(HR=3.725,95%CI1.943~7.139,P＜0.001).在组合组中，PAX8阴性和有限阶段组的OS最有希望.
■PAX8在SCLC标本中的表达率并不低。它在小细胞肺癌中具有预后价值。
