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Abstract：
Anaplastic thyroid carcinoma (ATC) is a highly aggressive form of thyroid cancer with poor prognosis. Differentiated thyroid carcinoma (DTC) including papillary thyroid carcinoma (PTC) is more common and known to have a favorable outcome after treatment. Here, we report a case of a 59-year-old lady with a long-standing goiter presenting with a discharging anterior neck mass. Fine-needle aspiration cytology (FTAC) of the mass resulted with malignant cells. She underwent surgery, and histopathological examination revealed both ATC and PTC features. Mutation analysis was also performed, and results were positive for BRAF 600VE mutation. She received radiotherapy and also chemotherapy post-surgery. Treatment was well tolerated. The relatively favorable survival of this patient may suggest that synchronous ATC and DTC may have better prognosis than ATC alone. The objective of this article is to report the unique clinical presentation and favorable prognosis with combined treatment modalities.
摘要：
间变性甲状腺癌（ATC）是一种高度侵袭性的甲状腺癌，预后不良。包括甲状腺乳头状癌（PTC）在内的分化型甲状腺癌（DTC）更为常见，并且已知在治疗后具有良好的预后。这里,我们报告了一例59岁的女性，患有长期甲状腺肿，表现为颈部前肿块。肿块的细针抽吸细胞学（FTAC）导致恶性细胞。她接受了手术,组织病理学检查显示ATC和PTC特征。还进行了突变分析，结果为BRAF600VE突变阳性。她接受了放疗和术后化疗。治疗耐受性良好。该患者的相对良好的生存率可能表明，同步ATC和DTC可能比单独ATC具有更好的预后。本文的目的是报告联合治疗方式的独特临床表现和良好预后。
