背景:早期评估骨质疏松性椎体压缩骨折(OVCF)骨不连的风险有利于早期临床决策。然而,缺乏对OVCF骨不连危险因素的全面了解.
方法:我们进行了一项病例对照研究,以调查OVCF骨不连的危险因素。在2011年1月至2021年12月期间接受非联合OVCF手术的患者有资格作为病例纳入。在同一时期通过MRI证实OVCF成功愈合的患者被确定为对照。患者人口统计学,合并症,提取空腹血液检测数据进行分析。
结果:共纳入201例非联合OVCF患者和1044例对照,以评估非联合OVCF的危险因素。性别差异有统计学意义,年龄,高血压患者的数量,比较两组OVCF后卧床患者人数及BMDT评分。Logistic回归分析显示,女性患者发生OVCF骨不连的风险高于男性患者,饮酒,糖尿病,高血压是OVCF骨不连的危险因素,卧床休息和脊柱支持是防止OVCF骨不连的保护因素。我们还发现年龄,BMD,FBG,β-CTX与非联合OVCFs呈正相关,HGB和1,25-(OH)2VitD3水平与非联合OVCFs呈负相关。
结论:吸烟,饮酒,糖尿病和高血压是OVCF骨不连的危险因素,卧床休息和脊柱支持是防止OVCF骨不连的保护因素。年龄,BMD,FBG和β-CTX与非联合OVCFs呈正相关,而HGB和1,25-(OH)2VitD3水平与OVCFs不一致呈负相关。根据我们的研究结果,我们建议卧床休息或脊柱支撑至少连续3周对于降低OVCF骨不连的风险是必要的.
BACKGROUND: Early assessment of the risk of nonunion in osteoporotic vertebral compression fracture (OVCF) is beneficial to early clinical decision making. However, a comprehensive understanding of the risk factors for OVCF nonunion is lacking.
METHODS: We conducted a case-control study to investigate risk factors for OVCF nonunion. Patients who underwent surgery for nonunited OVCFs between January 2011 and December 2021 were eligible for inclusion as cases. Patients with successful OVCF healing confirmed by MRI over the same period were identified as controls. Patient demographics, comorbidities, and fasting blood test data were extracted for analysis.
RESULTS: A total of 201 patients with nonunited OVCFs and 1044 controls were included to evaluate the risk factors for nonunited OVCFs. There were statistically significant differences in sex, age, number of patients with hypertension, number of patients on bed rest after OVCF and T-score of BMD between the two groups. Logistic regression showed that female patients had a higher risk of OVCF nonunion than male patients and that smoking, drinking, diabetes, and hypertension were risk factors for nonunion of OVCFs, while bed rest and spinal support were protective factors against nonunion of OVCFs. We also found that age, BMD, FBG, and β-CTX were positively correlated with nonunited OVCFs, and that HGB and 1,25-(OH)2VitD3 level were negatively correlated with nonunited OVCFs.
CONCLUSIONS: Smoking, drinking, diabetes and hypertension were risk factors for nonunion of OVCFs, while bed rest and spinal support were protective factors against nonunion of OVCFs. Age, BMD, FBG and β-CTX were positively correlated with nonunited OVCFs, while HGB and 1,25-(OH)2VitD3 level were negatively correlated with nonunited OVCFs. Based on the results of our study, we suggest that bed rest or spinal support for at least 3 consecutive weeks is necessary to reduce the risk of OVCFs nonunion.