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Abstract：
Adjacent vertebral fracture (AVF) is a serious complication of percutaneous vertebroplasty (PVP) or kyphoplasty (PKP) for osteoporotic vertebral compression fracture (OVCF). This study aimed to explore the incidence and risk factors of AVF following PVP or PKP in postmenopausal women. The incidence of AVF was determined by spinal radiographic examinations. The potential risk factors of AVF were identified by univariate analysis, followed by multivariate logistic regression analyses to determine the independent risk factors. In total, 674 postmenopausal women who were treated with PVP or PKP from December 2019 to February 2022 were enrolled in the study. Among them, 58 (8.61%) women experienced an AVF following PVP or PKP. After adjusting for confounding factors, BMI (OR [95% CI] 0.863 [0.781-0.952]; p = 0.003), previous history of OVCF (OR [95% CI] 1.931 [1.044-3.571]; p = 0.036), and Hounsfield unit (HU) value (OR [95% CI] 0.979 [0.967-0.990]; p < 0.001) were found to be independent risk factors of AVF following PVP or PKP in postmenopausal women. The ROC analysis revealed that the BMI and HU thresholds were 21.43 and 65.15, respectively. In conclusion, the incidence of AVF was 8.61%. BMI, previous history of OVCF and HU value were independent risk factors of AVF following PVP or PKP in postmenopausal women.
摘要：
相邻椎体骨折（AVF）是经皮椎体成形术（PVP）或椎体后凸成形术（PKP）治疗骨质疏松性椎体压缩性骨折（OVCF）的严重并发症。本研究旨在探讨绝经后妇女PVP或PKP后AVF的发生率及危险因素。通过脊柱影像学检查确定AVF的发生率。通过单因素分析确定AVF的潜在危险因素。然后进行多因素logistic回归分析以确定独立危险因素。总的来说,从2019年12月至2022年2月接受PVP或PKP治疗的674名绝经后妇女被纳入研究。其中,58名（8.61%）女性在PVP或PKP后出现AVF。在调整混杂因素后，BMI（OR[95%CI]0.863[0.781-0.952]；p=0.003），OVCF的既往史(OR[95%CI]1.931[1.044-3.571]；p=0.036)，和Hounsfield单位（HU）值（OR[95％CI]0.979[0.967-0.990];p<0.001）被发现是绝经后妇女PVP或PKP后AVF的独立危险因素。ROC分析显示BMI和HU阈值分别为21.43和65.15。总之,AVF的发生率为8.61%。BMI,既往OVCF史及HU值是绝经后妇女PVP或PKP后发生AVF的独立危险因素.
