我们报告了一名中年女孩,出现高烧和头痛4天。在此之后,孩子出现皮肤粘膜症状。她有明显的自身免疫性疾病家族史。测试显示炎症标志物增加。在生病的第六天,二维超声心动图显示冠状动脉增大,诊断为不完全川崎病(KD),并接受IVIG和阿司匹林治疗。一周之内,她弟弟妹妹,一个有病毒前驱症状的幼儿女孩,发展为皮肤粘膜病变和四肢皮下水肿。她的调查还显示炎症标志物升高和超声心动图改变,诊断为不完全KD。KD在兄弟姐妹中的后续发展,都表现出最初的病毒症状和自身免疫性疾病的家族史,导致了对潜在病毒触发因素的怀疑。这通过人腺病毒(3型)的病毒PCR研究得到证实。这些病例突显了急性腺病毒感染后兄弟姐妹中KD发展的异常发生。
We report a middle-childhood girl presented with high-grade fever and headache for 4 days. Following this, the child developed mucocutaneous symptoms. She had a notable family history of autoimmune disease. Tests revealed increased inflammatory markers. On the sixth day of illness, a two-dimensonal echocardiogram showed an enlarged coronary artery, diagnosed as incomplete Kawasaki disease (KD) and treated with IVIG and aspirin.Within a week, her younger sibling, an early-childhood girl presented with features of viral prodrome, developed mucocutaneous lesions and subcutaneous oedema of limbs. Her investigations also showed elevated inflammatory markers and echocardiographic changes, diagnosed as incomplete KD.The subsequent development of KD in siblings, both showing initial viral symptoms and a family history of autoimmune disease, led to the suspicion of a potential viral trigger. This was confirmed through viral PCR studies for human adenovirus (type 3). These cases highlight an unusual occurrence of KD developing in siblings following acute adenoviral infection.