背景:证据表明阴道微生物组和微环境在免疫状态中的作用。人乳头瘤病毒(HPV)感染广泛依赖于健康的阴道微环境。因此,本研究旨在探讨阴道微环境在高危型HPV(hr-HPV)感染率中的作用.
方法:这项横断面研究是对512名hr-HPV阳性(n=212)或阴性(n=300)感染的女性进行的。对妇女的阴道样本进行了检查,以了解是否感染了阴道加德纳菌。此外,嗜酸乳杆菌,pH值,和酶活性(如过氧化氢酶,脯氨酸氨基肽酶,和白细胞酯酶)在两组之间进行比较。此外,对阴道样本进行了组织病理学研究.
结果:酵母菌和G.vaginalis感染率较高,嗜酸乳杆菌的感染率较低,在hr-HPV阳性感染的女性中显着观察到(P0.001)。此外,组织病理学结果显示,hr-HPV阳性组的宫颈上皮内瘤变I-III级和宫颈癌病变明显高于对照组.
结论:hr-HPV感染与阴道微环境显著相关,它可能是高度宫颈病变率升高的危险因素。
BACKGROUND: Evidence suggests the role of the vaginal microbiome and microenvironment in the immunity state. The human papillomavirus (HPV) infection is widely dependent on the healthy vaginal microenvironment. Hence, this study aimed to investigate the role of the vaginal microenvironment in the rate of high-risk HPV (hr-HPV) infection.
METHODS: This cross-sectional study was performed on 512 women with hr-HPV positive (n=212) or negative (n=300) infection. The vaginal samples of women were examined regarding yeas and Gardnerella vaginalis infection. Also, Lactobacillus acidophilus, pH, and enzyme activity (such as catalase, proline aminopeptidase, and leucocyte esterase) were compared between the two groups. Also, the histopathological study was performed on the vaginal samples.
RESULTS: The higher rate of yeast and G. vaginalis infections as well as decreased L. acidophilus, were significantly observed in women with hr-HPV positive infection (P0.001). Also, histopathological findings indicated that cervical intraepithelial neoplasia grade I-III and cervical cancer lesions were markedly higher in hr-HPV positive group compared with control women.
CONCLUSIONS: The hr-HPV infection was markedly correlated to vaginal microenvironments, and it could a risk factor for the elevation of the rate of high-grade cervical lesions.