PDF(Pubmed)
Abstract：
Dietary interventions represent an interesting alternative to pharmacological treatments for improving the quality of life (QoL) of subjects suffering from gastroesophageal reflux disease (GERD). This randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of a food supplement (FS) containing a probiotic strain, bioactive peptides, and vitamins in relieving heartburn/dyspeptic symptoms in subjects with mild-to-moderate GERD. Fifty-six adult participants were randomly assigned to receive the placebo or the active FS for 28 days. Subjects were asked to record daily the frequency and intensity of heartburn episodes and the intake of over- the-counter (OTC) medications. GERD-QoL and self-assessment questionnaires were also completed every two weeks and at the end of the treatment, respectively. FS was effective in achieving a progressive and significant reduction of heartburn frequency and severity, with an intergroup significant difference at the end of the treatment period. FS group also reported a reduction in the OTC medication intake, whereas placebo administration did not modify the OTC intake. Results from the QoL and self-assessment questionnaires showed that FS administration achieved a progressive and statistically significant intragroup and intergroup improvement in the QoL score and a higher positive response with respect to the placebo treatment.
摘要：
饮食干预代表了用于改善患有胃食管反流病（GERD）的受试者的生活质量（QoL）的药物治疗的有趣替代方案。这个随机的，双盲,安慰剂对照研究旨在评估含有益生菌菌株的食品补充剂（FS）的功效，生物活性肽，和维生素可缓解轻度至中度GERD患者的胃灼热/消化不良症状。56名成年参与者被随机分配接受安慰剂或活性FS28天。要求受试者每天记录胃灼热发作的频率和强度以及非处方药(OTC)的摄入。GERD-QoL和自我评估问卷也每两周完成一次，并在治疗结束时完成，分别。FS可有效实现胃灼热频率和严重程度的进行性和显着降低，在治疗期结束时，组间差异显著。FS组还报告了OTC药物摄入量的减少，而安慰剂给药并没有改变OTC的摄入量。QoL和自我评估问卷的结果表明，FS管理在QoL评分方面实现了组内和组间的渐进性和统计学上显着的改善，并且相对于安慰剂治疗具有更高的积极响应。
