未经证实:败血症生存运动指南建议在败血症性休克患者中使用有创血压(IBP)测量,没有指定与感染性休克严重程度相关的首选动脉部位的准确性。这项研究的目的是确定感染性休克患者股动脉和桡动脉部位之间的平均动脉压(MAP)梯度。
UNASSIGNED:这项前瞻性研究是在一所大学医院的20张病床的ICU中进行的。在接受去甲肾上腺素(≥0.1μg/kg/min)的脓毒性休克患者中,同时测量股动脉和桡动脉部位的MAP,对接受高剂量去甲肾上腺素(≥0.3μg/kg/min)的患者进行预先计划的亚组分析。
未经证实:研究的所有80名患者的去甲肾上腺素剂量中位数,包括59个高剂量患者,为0.4(0.28-0.7)μg/kg/min。总的来说,同时测量股动脉和桡动脉部位的MAP(mmHg)产生的平均(95%CI)MAP值分别为81(79-83)和78(76-80),分别,平均差为3.3(2.67-3.93),p<0.001。在Bland-Altman对MAP测量值的分析中,对于总体和高剂量队列,检测到的效应大小分别为1.14和1.04,分别,这表明在两个动脉部位中的每个部位进行的测量之间存在显着差异。Pearson相关系数表明,在接受高剂量去甲肾上腺素的患者中,MAP梯度与去甲肾上腺素剂量之间存在微弱但具有统计学意义的相关性(r=0.289;p=0.026;95%CI0.036-0.508)。
未经证实:在脓毒性休克患者中,股骨部位的MAP读数高于桡骨部位,特别是那些接受高剂量去甲肾上腺素的人。
未经评估:[ClinicalTrials.gov],标识符[NCT03475667]。
UNASSIGNED: The guidelines of the Surviving Sepsis Campaign suggest using invasive blood pressure (IBP) measurement in septic shock patients, without specifying for a preferred arterial site for accuracy in relation to the severity of septic shock. The objective of this study was to determine the mean arterial pressure (MAP) gradient between the femoral and radial artery sites in septic shock patients.
UNASSIGNED: This prospective study was carried out at a 20-bed ICU in a university hospital. Simultaneous MAP measurements at femoral and radial arterial sites were obtained in septic shock patients receiving norepinephrine (≥0.1 μg/kg/min), with a pre-planned subgroup analysis for those receiving a high dose of norepinephrine (≥0.3 μg/kg/min).
UNASSIGNED: The median norepinephrine dose across all 80 patients studied, including 59 patients on a high dose, was 0.4 (0.28-0.7) μg/kg/min. Overall, simultaneous measurement of MAP (mmHg) at the femoral and radial arterial sites produced mean (95% CI) MAP values of 81 (79-83) and 78 (76-80), respectively, with a mean difference of 3.3 (2.67-3.93), p < 0.001. In Bland-Altman analysis of MAP measurements, the detected effect sizes were 1.14 and 1.04 for the overall and high-dose cohorts, respectively, which indicates a significant difference between the measurements taken at each of the two arterial sites. The Pearson correlation coefficient indicated a weak but statistically significant correlation between MAP gradient and norepinephrine dose among patients receiving a high dose of norepinephrine (r = 0.289; p = 0.026; 95% CI 0.036-0.508).
UNASSIGNED: In septic shock patients, MAP readings were higher at the femoral site than at the radial site, particularly in those receiving a high dose of norepinephrine.
UNASSIGNED: [ClinicalTrials.gov], identifier [NCT03475667].