PDF(Pubmed)
Abstract：
Laparoscopic ovariectomy under general anesthesia was planned in a 10-year-old, 146 kg, apparently healthy female African lion (Panthera leo). The lion was immobilized via intramuscular darts containing midazolam (0.033 mg/kg), medetomidine (50 µg/kg) and ketamine (2.5 mg/kg), and intubated using an endotracheal tube (16 mm internal diameter). The anesthesia was maintained using sevoflurane (0.9-2.1% end-tidal concentration), in combination with remifentanil (0.1 µg/kg/min) and ketamine (11 µg/kg/min) at a constant rate infusion (CRI), with Hartmann\'s solution (5 mL/kg/hr). Surgery was conducted with stable vital signs, but hypotension (mean arterial blood pressure 55 mmHg) developed, requiring dobutamine treatment. The hypotension was effectively controlled by adjusting dobutamine from 5 µg/kg/min to 0.2 to 0.3 µg/kg/min. This case suggests possibilities that dosages in this range can be clinically useful for peri-anesthetic hypotension in lions.
摘要：
腹腔镜卵巢切除术在全身麻醉下计划在10岁，146kg,显然健康的雌性非洲狮子（Pantheraleo）。狮子通过含有咪达唑仑（0.033mg/kg）的肌内飞镖固定，美托咪定（50µg/kg）和氯胺酮（2.5mg/kg），并且使用气管内导管(16mm内径)进行插管。使用七氟醚维持麻醉（潮气末浓度为0.9-2.1％），以恒定速率输注（CRI）与瑞芬太尼（0.1µg/kg/min）和氯胺酮（11µg/kg/min）联合使用，Hartmann溶液（5mL/kg/hr）。手术进行时生命体征稳定,但出现低血压（平均动脉血压55mmHg），需要多巴酚丁胺治疗.通过将多巴酚丁胺从5µg/kg/min调节至0.2至0.3µg/kg/min，可以有效控制低血压。这种情况表明，该范围内的剂量可能在临床上对狮子的麻醉低血压有用。
