流行病学发现表明,体脂分布的测量值可预测健康结果,而与体重指数(BMI)评估的整体体脂无关。本研究旨在评估2型糖尿病合并非酒精性脂肪性肝病患者整体和区域脂肪与肝脂肪变性和纤维化严重程度的关系。
■生物电阻抗分析和两个新开发的人体测量指标,即,身体形状指数(ABSI)和身体圆度指数(BRI),用来估计体内脂肪。根据纤维扫描参数,显著肝纤维化和严重脂肪变性定义为≥F2和>66%,分别。
■较高的总脂肪(比值比[OR]1.107,95%置信区间(CI)1.038-1.182,p=0.002),躯干脂肪(OR1.136,95%CI1.034-1.248,p=0.008)和腿部脂肪(OR1.381,95%CI1.139-1.674,p=0.001)与肝纤维化相关。然而,与全身脂肪(OR1.088,95%CI1.017-1.164,p=0.014)和腿部脂肪(OR1.317,95%CI1.066-1.628,p=0.011)相比,躯干脂肪与严重的肝脏脂肪变性无关.BRI的表现比躯干好,腿部和全身脂肪预测肝脂肪变性(OR2.186,95%CI1.370-3.487,p=0.001)和纤维化(OR2.132,95%CI1.419-3.204,p<0.001)。此外,躯干/腿部脂肪比和ABSI不是脂肪变性或纤维化的独立预测因子(p>0.05).
■BRI显示出比其他肥胖指标更高的预测能力来识别肝脏脂肪变性和僵硬度。此外,躯干肥胖程度较高,腿,和整体身体与发展肝纤维化的风险增加有关。虽然躯干脂肪与严重的肝脏脂肪变性没有相关性,腿部脂肪和总脂肪的增加与肝脏脂肪变性有关.
UNASSIGNED: Epidemiologic findings suggest that measures of body fat distribution predict health outcomes independent of the overall body fat assessed by body mass index (BMI). This study aimed to evaluate the associations of overall and regional body fat with the severity of hepatic steatosis and fibrosis in type 2 diabetic patients with non-alcoholic fatty liver disease.
UNASSIGNED: Bioelectric impedance analysis and two newly developed anthropometric indices, namely, A Body Shape Index (ABSI) and Body Roundness Index (BRI), were used to estimate the body fat. Based on fibroscan parameters, significant hepatic fibrosis and severe steatosis were defined as ≥F2 and >66%, respectively.
UNASSIGNED: Higher total body fat (odds ratio [OR] 1.107, 95% confidence intervals (CI) 1.038-1.182, p = 0.002), trunk fat (OR 1.136, 95% CI 1.034-1.248, p = 0.008) and leg fat (OR 1.381, 95% CI 1.139-1.674, p = 0.001) were associated with liver fibrosis. However, in contrast to the total body fat (OR 1.088, 95% CI 1.017-1.164, p = 0.014) and leg fat (OR 1.317, 95% CI 1.066-1.628, p = 0.011), the trunk fat was not associated with severe hepatic steatosis. BRI performed better than trunk, leg and total body fat in predicting hepatic steatosis (OR 2.186, 95% CI 1.370-3.487, p = 0.001) and fibrosis (OR 2.132, 95% CI 1.419-3.204, p < 0.001). Moreover, the trunk to leg fat ratio and ABSI were not independent predictors of either steatosis or fibrosis (p > 0.05).
UNASSIGNED: BRI revealed a superior predictive ability for identifying the degree of hepatic steatosis and stiffness than other obesity indices. Additionally, higher levels of adiposity in the trunk, legs, and overall body were linked to an increased risk of developing liver fibrosis. Although trunk fat did not show an association with severe hepatic steatosis, an increase in leg and total fat was related to liver steatosis.