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Abstract：
Introduction Chronic liver disease progression leads to liver fibrosis/cirrhosis. Transient Elastography is used for staging liver fibrosis but ascites, obesity, and operator experience limit its applicability. In this study, we compared various non-invasive serum indices in predicting fibrosis in chronic liver disease patients. Materials and methods A total of 142 cases of confirmed Chronic Liver Disease were included. Quantitative determination of liver stiffness by Transient Elastography and relevant blood investigations was done. We compared the liver stiffness measurement by Transient Elastography and fibrosis indices, i.e., Aspartate Transaminase (AST) to Alanine Transaminase (ALT) Ratio (AAR), AST to Platelet Ratio Index (APRI), Fibrosis Index (FI), Fibrosis-4 (FIB-4) Index, Age-Platelet Index (API), Pohl score, and Fibrosis Cirrhosis Index (FCI) with Novel Fibrosis Index (NFI), to predict liver fibrosis stages. Results The optimum cutoff of NFI for the F4 stage was ≥ 6670 with a sensitivity of 75.8% and specificity of 81.8%, for the F3 stage was ≥ 2112 with a sensitivity of 63.6% and specificity of 72.7%, and for the F2 stage was ≥ 1334 with a sensitivity of 100% and specificity of 56.3%. The NFI had the maximum area under the curve compared to other indices in predicting fibrosis stages. Conclusion The Novel Fibrosis Index was the best in predicting fibrosis stages in Chronic Liver Disease patients, with good performance in predicting the F4 stage.
摘要：
引言慢性肝病进展导致肝纤维化/肝硬化。瞬时弹性成像用于分期肝纤维化，但腹水，肥胖，和操作员经验限制了其适用性。在这项研究中,我们比较了各种非侵入性血清指标在预测慢性肝病患者纤维化中的作用。材料与方法收集142例确诊的慢性肝病患者。通过瞬时弹性成像和相关血液检查定量测定肝脏硬度。我们比较了瞬时弹性成像和纤维化指数的肝脏硬度测量，即，天冬氨酸转氨酶（AST）与丙氨酸转氨酶（ALT）的比值（AAR），AST与血小板比率指数（APRI），纤维化指数（FI），纤维化-4（FIB-4）指数，年龄-血小板指数（API），Pohl得分,和纤维化肝硬化指数（FCI）与新型纤维化指数（NFI），预测肝纤维化阶段。结果F4期NFI的最佳截止值≥6670,敏感性为75.8%,特异性为81.8%,对于F3期≥2112，敏感性为63.6%，特异性为72.7%，F2期≥1334,敏感性为100%,特异性为56.3%.与预测纤维化分期的其他指标相比，NFI的曲线下面积最大。结论新型纤维化指数是预测慢性肝病患者纤维化分期的最佳指标。在预测F4阶段方面表现良好。
