纤维化相关疾病(FRD)包括心肌纤维化等疾病,肺纤维化,肝纤维化,肾纤维化,和其他人。纤维化的影响可能是严重的,导致器官功能障碍,减少功能,甚至器官衰竭,导致重大健康问题。目前,临床上缺乏有效的现代抗纤维化药物。然而,中药对这类疾病的医治具有必定的有益感化。当归,具有可观的药用价值,在最近的研究中,它的抗纤维化特性引起了人们的注意。在过去的几年里,关于当归多糖(ASP)影响的实验研究越来越多,当归水提取物,当归注射液,和当归复方制剂治疗纤维化相关疾病,激发研究人员的兴趣。本文旨在巩固当归治疗纤维化相关疾病的研究进展,为前瞻性调查提供见解。文献检索包括核心电子数据库,包括百度文学,CNKI,谷歌学者,PubMed,和WebofScience。所应用的搜索利用指定的关键词来提取关于植物的药理学和植物化学属性的相关信息。调查显示,当归有可能通过调节炎症来阻碍纤维化疾病的发展,氧化应激,免疫反应,和新陈代谢。ASP,当归提取物,当归注射液,和当归复方制剂进行了广泛的考察和讨论。这些成分表现出显著的抗纤维化活性。实质上,本文旨在深入了解当归在治疗纤维相关疾病中的作用。器官纤维化表现在几乎所有的组织和器官,由于其广泛发生,对全球公共卫生构成了严峻挑战,具有挑战性的早期诊断,预后不良。尽管流行,治疗选择有限,它们的功效受到限制。在过去的几年里,许多研究探索了中药对器官纤维化的保护作用,当归作为一种多功能的自然疗法脱颖而出。本文对器官纤维化的发病机制进行了综述,并总结了近二十年来肝脏等各器官纤维化的治疗进展。肺,肾,和心脏。本文重点介绍了当归有效成分通过多靶点、多渠道调控相关信号通路,无论是作为单一药物还是作为复方处方使用。
Fibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medicinal value, has garnered attention for its anti-fibrosis properties in recent investigations. In the past few years, there has been a growing number of experimental inquiries into the impact of angelica polysaccharide (ASP), angelica water extract, angelica injection, and angelica compound preparation on fibrosis-associated ailments, piquing the interest of researchers. This paper aims to consolidate recent advances in the study of Angelica sinensis for the treatment of fibrosis-related disorders, offering insights for prospective investigations. Literature retrieval included core electronic databases, including Baidu Literature, CNKI, Google-Scholar, PubMed, and Web of Science. The applied search utilized specified keywords to extract relevant information on the pharmacological and phytochemical attributes of plants. The investigation revealed that Angelica sinensis has the potential to impede the advancement of fibrotic diseases by modulating inflammation, oxidative stress, immune responses, and metabolism. ASP, Angelica sinensis extract, Angelica sinensis injection, and Angelica sinensis compound preparation were extensively examined and discussed. These constituents demonstrated significant anti-fibrosis activity. In essence, this
review seeks to gain a profound understanding of the role of Angelica sinensis in treating fiber-related diseases. Organ fibrosis manifests in nearly all tissues and organs, posing a critical challenge to global public health due to its widespread occurrence, challenging early diagnosis, and unfavorable prognosis. Despite its prevalence, therapeutic options are limited, and their efficacy is constrained. Over the past few years, numerous studies have explored the protective effects of traditional Chinese medicine on organ fibrosis, with Angelica sinensis standing out as a multifunctional natural remedy. This paper provides a
review of organ fibrosis pathogenesis and summarizes the recent two decades\' progress in treating fibrosis in various organs such as the liver, lung, kidney, and heart. The
review highlights the modulation of relevant signaling pathways through multiple targets and channels by the effective components of Angelica sinensis, whether used as a single medicine or in compound prescriptions.