■肢端肥大症与几种呼吸系统疾病之间的关联,如阻塞性肺病或睡眠呼吸暂停,有人建议,但支气管扩张与肢端肥大症之间的关系尚不清楚。我们调查肢端肥大症是否与支气管扩张的发展有关。
■使用2006年至2016年的韩国国家健康保险系统数据库,我们研究了肢端肥大症患者(n=2593)和对照组(1:5年龄和性别匹配的受试者没有肢端肥大症,n=12965),平均随访期为8.9年。校正年龄后,采用Cox比例风险回归分析评估肢端肥大症患者与对照组相比的支气管扩张风险,性别,家庭收入,地点,2型糖尿病,高血压,和血脂异常。
■参与者的平均年龄为47.65岁,男性受试者占队列的45.62%。肢端肥大症患者的支气管扩张发生率为3.64/1000人年,明显高于对照组(2.47/1000人年)(对数秩检验p=0.002)。在多变量Cox比例风险回归模型中,校正年龄后,肢端肥大症患者的支气管扩张风险显著高于对照组(HR:1.49;95%CI:1.15-1.94,p=0.0025),性别,家庭收入,地点,2型糖尿病,高血压,和血脂异常。
■我们的结果表明肢端肥大症可能与支气管扩张有关。
UNASSIGNED: Associations between acromegaly and several respiratory diseases, such as obstructive lung disease or sleep apnea, have been suggested, but the relationship between bronchiectasis and acromegaly is unclear. We investigated whether acromegaly is related to the development of bronchiectasis.
UNASSIGNED: Using the Korean National Health Insurance System database between 2006 and 2016, we studied the relationship between acromegaly and bronchiectasis in patients with acromegaly (n=2593) and controls (1:5 age- and sex-matched subjects without acromegaly, n=12965) with a mean follow-up period of 8.9 years. Cox proportional hazards regression analysis was used to assess the risk of bronchiectasis in patients with acromegaly compared with controls after adjusting for age, sex, household income, place, type 2 diabetes, hypertension, and dyslipidemia.
UNASSIGNED: The mean age of the participants was 47.65 years, and male subjects comprised 45.62% of the cohort. The incidence rate of bronchiectasis in patients with acromegaly was 3.64 per 1,000 person-years and was significantly higher than that in controls (2.47 per 1,000 person-years) (log-rank test p = 0.002). In multivariable Cox proportional hazards regression modeling, the risk of bronchiectasis was significantly higher in patients with acromegaly than that in controls (HR: 1.49; 95% CI: 1.15-1.94, p = 0.0025) after adjusting for age, sex, household income, place, type 2 diabetes, hypertension, and dyslipidemia.
UNASSIGNED: Our results suggest that acromegaly may be associated with bronchiectasis.